DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gpo3 and gpd2

DIOPT Version :9

Sequence 1:	NP_609667.2	Gene:	Gpo3 / 34776	FlyBaseID:	FBgn0028848	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_005165898.1	Gene:	gpd2 / 751628	ZFINID:	ZDB-GENE-030131-4869	Length:	729	Species:	Danio rerio

Alignment Length:	662	Identity:	235/662 - (35%)
Similarity:	381/662 - (57%)	Gaps:	63/662 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VPSRAEHVNALK-AEEFDVLIIGGGAVGCGCAVDAACRGLKTALIEAEDFASGSSSRTSKLIDGS 67
            :|:|.|.::.|: .||||||::||||.|.|||:||..|.|||||:|..||:||:|||::|||.|.
Zfish    56 LPTREEQLSTLRNTEEFDVLVVGGGATGSGCALDAVTRNLKTALVERSDFSSGTSSRSTKLIHGG 120

  Fly    68 GSYLGTALREKDVEQLYIMLQMMSERVTMLKNAPHLNRIQPMIIPIYSFLQMPCTWLGLKVYDWI 132
            ..||..|:.:.|.||..::.:.:.||..:|:.||||:...|:::|:|.:.|:|..|.|:|:||.:
Zfish   121 VRYLQKAIMKLDYEQYMMVKEALHERANLLEIAPHLSAPLPIMLPVYKWWQLPYYWAGIKMYDLV 185

  Fly   133 SAASNIRGSHIISREATMYEFPLLKTDGLRGGVVYYDGQVDDARMCVALVMTAVALGANVGNHME 197
            :.:..::.|:::|:...:..||:||.|.|.|.:||||||.:||||.:|:.:||...||.:.|:.|
Zfish   186 AGSQCLKSSYVLSKSKALEFFPMLKKDKLVGAIVYYDGQHNDARMNLAIALTAARHGAAIANYTE 250

  Fly   198 VVEIM----PQEGCCRVVSV--KDKISCEQFYIQSKAVINATGSSTDAIRQMDKEGTAPILLPTL 256
            ||.::    |:.|..:|...  :|.::.::|.|::|.||||||..||::|:||.:.||.|..|:.
Zfish   251 VVHLLKKPDPKTGQEKVCGARCRDVVTGQEFDIRAKCVINATGPFTDSLRKMDNQKTANICQPSA 315

  Fly   257 ETQVSLPRYFGSGHYGLLSPALKNDDLTVYMVPFENHMVLGSREVDLDEVSSRGSPTPDPDDVDC 321
            ...:.:|.|:...:.|||.|| .:|...::.:|:|...:.|:.:.. .||::.  |.|..||::.
Zfish   316 GVHIVIPGYYSPDNMGLLDPA-TSDGRVIFFLPWEKMTIAGTTDTP-TEVTAH--PIPMEDDINF 376

  Fly   322 LLEAAKKRMDPCVELGRCHVLSAWTAIKASVSCPTDKENDDDKRGTPINSYMIEVSPDGLITLAG 386
            :|...:..:.|.||:.|..||:||:.|:..|:.|:.|:.....|     ::::.||..||||:||
Zfish   377 ILSEVRNYLSPDVEVRRGDVLAAWSGIRPLVTDPSSKDTQSICR-----NHIVNVSDSGLITIAG 436

  Fly   387 GRWSSYRVMAADAVDLAIKSCGLCDDHVTSSWTQDLKLDGAESWCCMLPLEFVQDYGVPMDVAHH 451
            |:|::||.||.:.:|.|||:..|   ....|.|..|.|:|.:.|...|.:..|||||:..:||.|
Zfish   437 GKWTTYRSMAEETLDAAIKAHNL---SAGPSRTVGLTLEGGKDWTPTLYIRLVQDYGLENEVAQH 498

  Fly   452 ISDSYGYNGHALFSQA-------PDLKKRLHPSFPYIEAEIQYAMRNEYACTLVDIIARRLRIAF 509
            ::.:||.....:...|       |.:.|||...|||||:|:|||:: |||||.:|:|:||.|:.|
Zfish   499 LAATYGGRSFEVAKMAQVTGKRWPIVGKRLVSEFPYIESEVQYAIK-EYACTAIDVISRRTRLGF 562

  Fly   510 VDAAATLHMLPRILKIMAGENGWDEEEQKEQMVAAQEFLVRQMGLGSIVQPRSTSKSKPKKKGSS 574
            ::..|....||||::||..|..|.|:::||::.||:.||..:||.        .::|:...|.:.
Zfish   563 LNVQAADEALPRIVEIMGKELQWTEQKKKEELEAAKNFLYLEMGY--------KARSEQLSKTTE 619

  Fly   575 EGCCCRAAVRRGARSYSMEISKK-----ICVQPLVQ-----------HRSMSSM----------- 612
            .....:...|...|.|..:...|     :.||.:::           |..::.:
Zfish   620 ISLTPQEVARYKKRFYKFDKESKGFITTVDVQQVLERLSIHIDENALHEILNEVDLNKNGQVELD 684

  Fly   613 -FLPLMTSLSYG 623
             ||.||:::..|
Zfish   685 EFLQLMSAVQRG 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo3	NP_609667.2	GlpA	7..554	CDD:223651	219/560 (39%)
Gpo3	NP_609667.2	DAO_C	417..537	CDD:293506	52/126 (41%)
gpd2	XP_005165898.1	PLN02464	2..601	CDD:215257	217/557 (39%)
		NADB_Rossmann	71..>109	CDD:304358	25/37 (68%)
		DAO_C	464..590	CDD:293506	52/126 (41%)
		EFh	629..691	CDD:238008	10/61 (16%)
		EF-hand_7	631..690	CDD:290234	8/58 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1659
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020