DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gpo3 and Gpo1

DIOPT Version :9

Sequence 1:	NP_609667.2	Gene:	Gpo3 / 34776	FlyBaseID:	FBgn0028848	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001097332.1	Gene:	Gpo1 / 47611	FlyBaseID:	FBgn0022160	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	241/587 - (41%)
Similarity:	366/587 - (62%)	Gaps:	28/587 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KVVPSRAEHVNAL-KAEEFDVLIIGGGAVGCGCAVDAACRGLKTALIEAEDFASGSSSRTSKLID 65
            :.:|.||:.:.:| ..||||||||||||.|.|||:|:..|||||||:|.:|||||:|||::|||.
  Fly    46 RTLPPRADQIKSLMSGEEFDVLIIGGGATGAGCALDSVTRGLKTALVELDDFASGTSSRSTKLIH 110

  Fly    66 GSGSYLGTALREKDVEQLYIMLQMMSERVTMLKNAPHLNRIQPMIIPIYSFLQMPCTWLGLKVYD 130
            |...||..|:...|:||..::.:.::||.|||::||||....|:::|:|::.|:|..|:|:|.||
  Fly   111 GGVRYLQKAILGLDLEQYRMVKEALAERATMLESAPHLTHPLPIMLPVYTWWQVPYYWVGIKAYD 175

  Fly   131 WISAASNIRGSHIISREATMYEFPLLKTDGLRGGVVYYDGQVDDARMCVALVMTAVALGANVGNH 195
            .::...|::.|:.:|::..:..||:||.|.|.|.:||||||.||||||:|:.:||...||.|.||
  Fly   176 LVAGDRNVKSSYYLSKKDALELFPMLKKDKLCGAIVYYDGQQDDARMCLAVALTAARHGATVCNH 240

  Fly   196 MEVVEIMPQ-EGCCRVV----SVKDKISCEQFYIQSKAVINATGSSTDAIRQMDKEGTAPILLPT 255
            :||.|::.: :|..:.|    .|||.||.::|.:::|.::||.|..||:||:||......|..|:
  Fly   241 VEVKELLKKDDGTGKQVLCGAKVKDHISGKEFTVKAKCIVNAAGPFTDSIRKMDNPTVKSICCPS 305

  Fly   256 LETQVSLPRYFGSGHYGLLSPALKNDDLTVYMVPFENHMVLGSREVDLDEVSSRGSPTPDPDDVD 320
            ....:.||.|:.....|||.|: .:|...::.:|::...:.|:.::.. |::.  :|||..|::.
  Fly   306 SGVHIVLPGYYSPDQMGLLDPS-TSDGRVIFFLPWQRQTIAGTTDLPC-EITH--NPTPTEDEIQ 366

  Fly   321 CLLEAAKKRMDPCVELGRCHVLSAWTAIKASVSCPTDKENDDDKRGTPINSYMIEVSPDGLITLA 385
            .:|...|..::..||:.|..|||||:.|:..||.|    |.||.:....| :::.|||..|||:|
  Fly   367 FILNEIKNYLNADVEVRRGDVLSAWSGIRPLVSDP----NKDDTQSLARN-HIVHVSPSNLITIA 426

  Fly   386 GGRWSSYRVMAADAVDLAIKSCGLCDDHVTSSWTQDLKLDGAESWCCMLPLEFVQDYGVPMDVAH 450
            ||:|::||.||...:|.|||:|.|..:. ..:.|..||::|.:.|...:.:..|||:|:..:||.
  Fly   427 GGKWTTYRAMAEHTIDAAIKACNLKPER-AEAVTSYLKIEGGQGWTPTMYIRLVQDFGLECEVAQ 490

  Fly   451 HISDSYGYNGHALFSQA-------PDLKKRLHPSFPYIEAEIQYAMRNEYACTLVDIIARRLRIA 508
            |::.|||....|:...|       |.:..|:||.||||:|||:|.:| |||||.||:||||||:|
  Fly   491 HLAKSYGDRAFAVSKMASLTGKRWPIIGNRIHPEFPYIDAEIRYGVR-EYACTAVDMIARRLRLA 554

  Fly   509 FVDAAATLHMLPRILKIMAGENGWDEEEQKEQMVAAQEFLVRQMGLGSIVQPRSTSKSKPKKKGS 573
            |::..|....||.|:.||..|.||.::|::.|:..|.|||..:|| .|:   ..|||.:...|.|
  Fly   555 FLNVQAAQEALPVIVDIMGEELGWSKDEKERQIKHATEFLANEMG-HSV---NRTSKERIPIKLS 615

  Fly   574 SE 575
            .|
  Fly   616 KE 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo3	NP_609667.2	GlpA	7..554	CDD:223651	232/559 (42%)
Gpo3	NP_609667.2	DAO_C	417..537	CDD:293506	54/126 (43%)
Gpo1	NP_001097332.1	PLN02464	9..594	CDD:215257	230/558 (41%)
		DAO_C	458..583	CDD:293506	54/125 (43%)
		EFh	624..684	CDD:238008
		EF-hand_7	624..683	CDD:290234
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440840
Domainoid	1	1.000	77	1.000	Domainoid score	I3086
eggNOG	1	0.900	-	-		E1_COG0578
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	175	1.000	Inparanoid score	I188
Isobase	1	0.950	-	0	Normalized mean entropy	S668
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	1	1.000	-	-		otm51316
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1659
	11	10.850