DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gpo3 and Y50E8A.6

DIOPT Version :9

Sequence 1:	NP_609667.2	Gene:	Gpo3 / 34776	FlyBaseID:	FBgn0028848	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_506640.2	Gene:	Y50E8A.6 / 190107	WormBaseID:	WBGene00013049	Length:	609	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	196/568 - (34%)
Similarity:	321/568 - (56%)	Gaps:	38/568 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VPSRAEHVNALKAEE-FDVLIIGGGAVGCGCAVDAACRGLKTALIEAEDFASGSSSRTSKLIDGS 67
            :|:|...:.:||.|: ||||:||||:.|.|.|:||..||||||::|..|:.||:||::|||:.|.
Worm    47 LPTRESIIESLKTEKRFDVLVIGGGSAGAGVALDAQTRGLKTAMVEYGDYCSGTSSKSSKLLHGG 111

  Fly    68 GSYLGTALREKDVEQLYIMLQMMSERVTMLKNAPHLNRIQPMIIPIYSFLQMPCTWLGLKVYDWI 132
            ..||.|||:|.|.|...|:.:.::||:.::|:||.|::..|:::|.|.:.|....|.|:||||::
Worm   112 VKYLETALKEFDYEHYQIVQEGLNERLNIMKSAPFLSQTFPVLVPTYKWWQKIYYWGGVKVYDFL 176

  Fly   133 SAASNIRGSHIISREATMYEFPLLKTDGLRGGVVYYDGQVDDARMCVALVMTAVALGANVGNHME 197
            :..:.::.|..:|:|..:...|.::.:||:|.::|||||.:|||:.:.:.:||:..||...||.|
Worm   177 AGKNVLKPSKFVSKEEAIEICPTIRQEGLKGAMLYYDGQGNDARLVLVVALTAIRNGAKCVNHTE 241

  Fly   198 VVEIMPQE-GCCRVVSVKDKISCEQFYIQSKAVINATGSSTDAIRQMDKEGTAPILLPTLETQVS 261
            .:.::... |......|||.||.|.:.|.||.|:||||...|.||:|..|....|::.:....::
Worm   242 CIGLLKDSYGKVNGALVKDHISGETYEIHSKVVVNATGPFNDHIREMADETRNKIIVGSSGIHLT 306

  Fly   262 LPRYFGSGHYGLLSPALKNDDLTVYMVPFENHMVLGSREVDLDEVSSRGSPTPDPDDVDCLLEAA 326
            :.:||..|:.||:.|. .:|...::..|:||..::|:.:   |......|||....::..:|:..
Worm   307 VAKYFCPGNAGLIVPK-SSDGRVIFAFPWENVTIVGTTD---DPTEPSHSPTVTEKEIQYILKEM 367

  Fly   327 KKRMDPCVELGRCHVLSAWTAIKASVSCP-TDKENDDDKRGTPINSYMIEVSPDGLITLAGGRWS 390
            .:..:...|:.|..|.|.|:.|:..|..| ..||::...||     ::::|.|.||||:|||:.:
Worm   368 NRAFEKEYEIKREDVTSIWSGIRGLVQDPKRQKEHNSLARG-----HLVDVGPTGLITIAGGKLT 427

  Fly   391 SYRVMAADAVD--------LAIKSCGLCDDHVTSSWTQDLKLDGAESWCCMLPLEFVQDYGVPMD 447
            ::|.||.:.|:        |..:.|          .|:.:..:||.::..||.....|:||:...
Worm   428 TFRHMAEETVNKLLDINKILEAQPC----------VTRGMMFEGAHNYTSMLYRTISQNYGIEEQ 482

  Fly   448 VAHHISDSYGYNGHALF-------SQAPDLKKRLHPSFPYIEAEIQYAMRNEYACTLVDIIARRL 505
            ||.|:..:||...:.:.       .:.|.:..||||.||::|||::||:: |||....||:|||.
Worm   483 VATHLCQTYGDKVYEVLKLCKSTGQKFPVIGHRLHPDFPFLEAEVRYAVK-EYARIPADILARRT 546

  Fly   506 RIAFVDAAATLHMLPRILKIMAGENGWDEEEQKEQMVAAQEFLVRQMG 553
            |::.:||.|...:||||:.|||.|..|...||........:||..:.|
Worm   547 RLSLLDARAARQVLPRIVAIMAEELKWSPSEQIFYFDEGMKFLKVENG 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gpo3	NP_609667.2	GlpA	7..554	CDD:223651	195/565 (35%)
Gpo3	NP_609667.2	DAO_C	417..537	CDD:293506	46/126 (37%)
Y50E8A.6	NP_506640.2	PLN02464	14..578	CDD:215257	191/550 (35%)
Y50E8A.6	NP_506640.2	DAO_C	452..578	CDD:293506	47/136 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0578
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S668
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D232701at33208
OrthoFinder	1	1.000	-	-		FOG0002536
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1659
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.760