DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ics and PIRL1

DIOPT Version :9

Sequence 1:	NP_001285902.1	Gene:	ics / 34774	FlyBaseID:	FBgn0028546	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_196204.1	Gene:	PIRL1 / 830470	AraportID:	AT5G05850	Length:	506	Species:	Arabidopsis thaliana

Alignment Length:	254	Identity:	84/254 - (33%)
Similarity:	120/254 - (47%)	Gaps:	29/254 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSN 82
            :|.:|.|.....:||:.:.|....|..|  .:..:..|.|.:|::..|...||.|.||..|::|.
plant   197 ILQQAAENPLDRVDLSGRKLKLLPEAFG--KIQGLLVLNLYNNQLQAIPDSIAGLHNLLELDVST 259

  Fly    83 NQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLN-------------EQ 134
            |.|..||.|:..:.||:|||||.|:|..||........|.|||.|||||.             |:
plant   260 NFLETLPDSIGLLSKLKILNVSCNKLTTLPDSICHCGSLVVLDASYNNLTYLPTNIGFELVKLEK 324

  Fly   135 V---------LPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDN--DLLELPREVGD 188
            :         ||.:...|.:||.|....|:...:|...|.|.||:.|.|..|  ||.:||...||
plant   325 LLIHLNKIRSLPTSIGEMRSLRYLDAHFNELNGLPNSFGLLTNLEYLNLSSNFSDLQDLPASFGD 389

  Fly   189 LVRLRELHIQNNRLQVLPPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYL 247
            |:.|:||.:.||::..||....   .|.|.:.:.:::||.|.|..|....|:..|..|:
plant   390 LISLQELDLSNNQIHSLPDAFG---TLVNLTKLNLDQNPLVVPPDEVVKQGVDAVKMYM 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_001285902.1	leucine-rich repeat	29..51	CDD:275380	5/21 (24%)
		leucine-rich repeat	52..84	CDD:275380	11/31 (35%)
		LRR_8	96..156	CDD:290566	28/81 (35%)
		leucine-rich repeat	98..120	CDD:275380	10/21 (48%)
		LRR	119..>222	CDD:227223	41/126 (33%)
		leucine-rich repeat	121..145	CDD:275380	13/45 (29%)
		leucine-rich repeat	146..168	CDD:275380	7/21 (33%)
		leucine-rich repeat	169..191	CDD:275380	11/23 (48%)
PIRL1	NP_196204.1	LRR_8	206..260	CDD:290566	16/55 (29%)
		leucine-rich repeat	208..228	CDD:275380	5/21 (24%)
		LRR_RI	<212..403	CDD:238064	67/192 (35%)
		leucine-rich repeat	229..251	CDD:275380	7/21 (33%)
		LRR_8	251..308	CDD:290566	27/56 (48%)
		leucine-rich repeat	252..274	CDD:275380	8/21 (38%)
		leucine-rich repeat	275..297	CDD:275380	10/21 (48%)
		leucine-rich repeat	298..321	CDD:275380	9/22 (41%)
		LRR_8	321..376	CDD:290566	15/54 (28%)
		leucine-rich repeat	322..344	CDD:275380	4/21 (19%)
		leucine-rich repeat	345..367	CDD:275380	7/21 (33%)
		LRR_8	366..426	CDD:290566	22/62 (35%)
		LRR_4	366..408	CDD:289563	18/41 (44%)
		leucine-rich repeat	368..392	CDD:275380	11/23 (48%)
		LRR_4	392..>426	CDD:289563	10/36 (28%)
		leucine-rich repeat	393..415	CDD:275380	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I2132
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960