DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ics and RSU1

DIOPT Version :9

Sequence 1:NP_001285902.1 Gene:ics / 34774 FlyBaseID:FBgn0028546 Length:283 Species:Drosophila melanogaster
Sequence 2:NP_036557.1 Gene:RSU1 / 6251 HGNCID:10464 Length:277 Species:Homo sapiens


Alignment Length:272 Identity:159/272 - (58%)
Similarity:211/272 - (77%) Gaps:6/272 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 MSKA-KKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNL 75
            |||: ||:::|:||.:.||:|::|:|:|:..::.|||.:|:||:|.|||||::::.|.||.|.||
Human     1 MSKSLKKLVEESREKNQPEVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNL 65

  Fly    76 EILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNF 140
            |:||..|||:.|||..:||:.||:.||:.:|||..||||||:.|.||||||:||||:|..|||||
Human    66 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNF 130

  Fly   141 FGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVL 205
            |.:.|||||||.|||||.:|.::|:|..||||.||||||:.||:|:|:|.:|:|||||.|||.||
Human   131 FYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195

  Fly   206 PPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPP 270
            |||:..|||...|.|.|.|.||||.|||:|:.||:|||.:|:::||||.:|.||:||   .|.||
Human   196 PPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQA---NPEPP 257

  Fly   271 KA--DKSKKASR 280
            |.  |||||.||
Human   258 KKNNDKSKKISR 269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
icsNP_001285902.1 leucine-rich repeat 29..51 CDD:275380 8/21 (38%)
leucine-rich repeat 52..84 CDD:275380 18/31 (58%)
LRR_8 96..156 CDD:290566 40/59 (68%)
leucine-rich repeat 98..120 CDD:275380 12/21 (57%)
LRR 119..>222 CDD:227223 67/102 (66%)
leucine-rich repeat 121..145 CDD:275380 17/23 (74%)
leucine-rich repeat 146..168 CDD:275380 14/21 (67%)
leucine-rich repeat 169..191 CDD:275380 15/21 (71%)
RSU1NP_036557.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24 11/22 (50%)
leucine-rich repeat 19..41 CDD:275380 8/21 (38%)
PLN00113 34..>200 CDD:215061 104/165 (63%)
LRR 1 41..63 11/21 (52%)
leucine-rich repeat 42..64 CDD:275380 12/21 (57%)
LRR 2 64..85 12/20 (60%)
leucine-rich repeat 65..87 CDD:275380 12/21 (57%)
LRR 3 87..109 13/21 (62%)
leucine-rich repeat 88..110 CDD:275380 12/21 (57%)
LRR 4 110..133 17/22 (77%)
leucine-rich repeat 111..135 CDD:275380 17/23 (74%)
LRR 5 135..156 14/20 (70%)
leucine-rich repeat 136..158 CDD:275380 14/21 (67%)
LRR 6 158..179 14/20 (70%)
leucine-rich repeat 159..181 CDD:275380 15/21 (71%)
LRR 7 181..202 14/20 (70%)
leucine-rich repeat 182..207 CDD:275380 17/24 (71%)
leucine-rich repeat 208..227 CDD:275380 12/18 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 250..277 13/23 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147108
Domainoid 1 1.000 157 1.000 Domainoid score I4172
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7521
Inparanoid 1 1.050 331 1.000 Inparanoid score I2448
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52835
OrthoDB 1 1.010 - - D1382533at2759
OrthoFinder 1 1.000 - - FOG0006365
OrthoInspector 1 1.000 - - oto89673
orthoMCL 1 0.900 - - OOG6_105610
Panther 1 1.100 - - LDO PTHR45752
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3641
SonicParanoid 1 1.000 - - X4633
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

Return to query results.
Submit another query.