DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ics and pidd1

DIOPT Version :9

Sequence 1:	NP_001285902.1	Gene:	ics / 34774	FlyBaseID:	FBgn0028546	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	XP_021326274.1	Gene:	pidd1 / 571033	ZFINID:	ZDB-GENE-081104-353	Length:	960	Species:	Danio rerio

Alignment Length:	265	Identity:	71/265 - (26%)
Similarity:	122/265 - (46%)	Gaps:	46/265 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 QSCIPVSAKMSKAKKVLDEARETHNPELDLADKGLSSFEELPGLF--------NMSNITRLTLSH 59
            :..:.|..::::.:.:.......|:|:.|          .||||.        ::|.:..|.||.
Zfish   142 ERALRVLPRLTQLRSLAIRGCRFHDPQGD----------PLPGLLSSLPDSVSSLSLLVHLDLSF 196

  Fly    60 NKISVISPGIANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVL 124
            |:.|.:...:.:..:|..|.|.:|.||.||..:.::..||.:::..|||::||:..|....||.|
Zfish   197 NRFSSLPSCLLSFSHLSELLLCHNNLTTLPEGIGALASLRRVSLLGNRLVDLPQDLGLLCGLEEL 261

  Fly   125 DLSYNNLNEQVLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDL 189
            |:|:|.|                         |.:|.|:|||:|||.|.|.:|.|..||..:|.|
Zfish   262 DVSFNLL-------------------------EKLPDELGQLQNLQRLELSNNRLRSLPETLGSL 301

  Fly   190 VRLRELHIQNNRLQVLPPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKI 254
            ..||:|.||:|.|:.:|..:..|.:|..   :.:..||...|.....|..::.|::..:.....:
Zfish   302 RSLRQLLIQSNDLRSVPDCLHSLPMLDK---LDVRNNPLGRPPTPPPLAQLTPVVEDSEIPELHL 363

  Fly   255 IYNRH 259
            .:|:|
Zfish   364 GFNQH 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_001285902.1	leucine-rich repeat	29..51	CDD:275380	5/29 (17%)
		leucine-rich repeat	52..84	CDD:275380	8/31 (26%)
		LRR_8	96..156	CDD:290566	15/59 (25%)
		leucine-rich repeat	98..120	CDD:275380	8/21 (38%)
		LRR	119..>222	CDD:227223	34/102 (33%)
		leucine-rich repeat	121..145	CDD:275380	7/23 (30%)
		leucine-rich repeat	146..168	CDD:275380	6/21 (29%)
		leucine-rich repeat	169..191	CDD:275380	10/21 (48%)
pidd1	XP_021326274.1	LRR	<148..366	CDD:227223	68/255 (27%)
		leucine-rich repeat	154..188	CDD:275380	7/43 (16%)
		leucine-rich repeat	189..211	CDD:275380	5/21 (24%)
		leucine-rich repeat	212..234	CDD:275380	8/21 (38%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		leucine-rich repeat	259..280	CDD:275380	12/45 (27%)
		leucine-rich repeat	281..303	CDD:275380	10/21 (48%)
		leucine-rich repeat	304..326	CDD:275380	9/21 (43%)
		Peptidase_S68	462..501	CDD:313651
		DD	846..932	CDD:326335
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0617
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900