DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ics and rsu1

DIOPT Version :9

Sequence 1:	NP_001285902.1	Gene:	ics / 34774	FlyBaseID:	FBgn0028546	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	XP_012820086.2	Gene:	rsu1 / 548412	XenbaseID:	XB-GENE-494282	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	272	Identity:	157/272 - (57%)
Similarity:	212/272 - (77%)	Gaps:	6/272 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MSKA-KKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNL 75
            |||: ||:::|:||.:.|::|:.|:|:::..::||||.:|:||:|.|||||::.:.|.||:|.||
Frog   118 MSKSLKKIVEESREKNVPDIDMCDRGIANMLDVPGLFTLSHITQLILSHNKLTTVPPNIADLKNL 182

  Fly    76 EILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNF 140
            |:||..|||:.|||..:||:.||:.||:.:|||.:||||||:.|.||||||:|||:||..|||||
Frog   183 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNSLPRGFGSLPALEVLDLTYNNMNENSLPGNF 247

  Fly   141 FGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVL 205
            |.:.|||||||.|||||.:|.::|:|..|||:.||||||:.||:|:|||.:|:|||||.|||.||
Frog   248 FYLTTLRALYLSDNDFEILPPDIGKLTKLQIISLRDNDLISLPKEIGDLTQLKELHIQGNRLTVL 312

  Fly   206 PPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPP 270
            |||:..|||...|.|.|.|.||||.|||:|:.:|:|||.:|:::||||.:|.||:||   .|.||
Frog   313 PPELGNLDLTGQKQVFKAENNPWVTPIADQFQVGVSHVFEYIRSETYKYLYGRHMQA---NPEPP 374

  Fly   271 KA--DKSKKASR 280
            |.  |||||.||
Frog   375 KKNNDKSKKISR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_001285902.1	leucine-rich repeat	29..51	CDD:275380	7/21 (33%)
		leucine-rich repeat	52..84	CDD:275380	18/31 (58%)
		LRR_8	96..156	CDD:290566	40/59 (68%)
		leucine-rich repeat	98..120	CDD:275380	12/21 (57%)
		LRR	119..>222	CDD:227223	67/102 (66%)
		leucine-rich repeat	121..145	CDD:275380	17/23 (74%)
		leucine-rich repeat	146..168	CDD:275380	14/21 (67%)
		leucine-rich repeat	169..191	CDD:275380	15/21 (71%)
rsu1	XP_012820086.2	LRR	<125..349	CDD:227223	128/223 (57%)
		leucine-rich repeat	159..181	CDD:275380	12/21 (57%)
		leucine-rich repeat	182..204	CDD:275380	12/21 (57%)
		leucine-rich repeat	205..227	CDD:275380	12/21 (57%)
		leucine-rich repeat	228..252	CDD:275380	17/23 (74%)
		leucine-rich repeat	253..275	CDD:275380	14/21 (67%)
		leucine-rich repeat	276..298	CDD:275380	15/21 (71%)
		leucine-rich repeat	299..324	CDD:275380	17/24 (71%)
		leucine-rich repeat	325..344	CDD:275380	12/18 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7521
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2393
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1382533at2759
OrthoFinder	1	1.000	-	-		FOG0006365
OrthoInspector	1	1.000	-	-		oto103486
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3641
SonicParanoid	1	1.000	-	-		X4633
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090