Protein Alignment ics and Sur-8

DIOPT Version :10

• Sequence 1: NP_609665.2
• Gene: ics / 34774
• FlyBaseID: FBgn0028546
• Length: 283
• Species: Drosophila melanogaster
• Sequence 2: NP_001262665.1
• Gene: Sur-8 / 42093
• FlyBaseID: FBgn0038504
• Length: 694
• Species: Drosophila melanogaster
• Alignment Length: 281
• Identity: 86/281 - (30%)
• Similarity: 126/281 - (44%)
• Gaps: 29/281 - (10%)

  Fly     4 SCIPVSAKMSKAKKVLDEARETHNPELDLADKGLSS-------------FEELP--GLFNMSNIT 53
            |.:|.:.|..|:   :||.....|....|.|..|:|             |...|  |....:|:.
  Fly   357 SSVPATLKNCKS---MDEFNVEGNGITQLPDGMLASLSGLTTITLSRNQFASYPTGGPAQFTNVY 418

  Fly    54 RLTLSHNKISVISPGI-ANLLNLEILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGA 117
            .:.|.||:|..|..|| :....|..||:..|.||.||:.:.:...:..||::.|.|..||.....
  Fly   419 SINLEHNRIDKIPYGIFSRAKGLTKLNMKENMLTALPLDIGTWVNMVELNLATNALQKLPDDIMN 483

  Fly   118 FPVLEVLDLSYNNLNEQVLPGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLEL 182
            ...||:|.||.|.|.:  :|.....:..||.|.|.:|..|.:|.|:|.|..||.|.|:.|.:..|
  Fly   484 LQNLEILILSNNMLKK--IPNTIGNLRKLRILDLEENRIEVLPHEIGLLHELQRLILQTNQITML 546

  Fly   183 PREVGDLVRLRELHIQNNRLQVLPPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYL 247
            ||.:|.|..|..|.:..|.||.||.||..|:.|.|   :.:.:||.:..:  .:.|.:...:.||
  Fly   547 PRSIGHLGNLTHLSVSENNLQFLPEEIGSLESLEN---LYINQNPGLEKL--PFELALCQNLKYL 606

  Fly   248 KTETYKI-IYNRHLQAGRSGP 267
            ..:...: .....:|||  ||
  Fly   607 NIDKCPLSTIPPEIQAG--GP 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_609665.2	leucine-rich repeat	29..51	CDD:275380	7/36 (19%)
		LRR	<31..>208	CDD:443914	64/192 (33%)
		leucine-rich repeat	52..84	CDD:275380	10/32 (31%)
		leucine-rich repeat	98..120	CDD:275380	6/21 (29%)
		leucine-rich repeat	121..145	CDD:275380	8/23 (35%)
		leucine-rich repeat	146..168	CDD:275380	10/21 (48%)
		leucine-rich repeat	169..191	CDD:275380	10/21 (48%)
Sur-8	NP_001262665.1	leucine-rich repeat	163..184	CDD:275380
		LRR	185..535	CDD:443914	55/182 (30%)
		leucine-rich repeat	185..207	CDD:275380
		leucine-rich repeat	208..230	CDD:275380
		leucine-rich repeat	231..253	CDD:275380
		leucine-rich repeat	254..276	CDD:275380
		leucine-rich repeat	277..299	CDD:275380
		leucine-rich repeat	300..322	CDD:275380
		leucine-rich repeat	323..345	CDD:275380
		leucine-rich repeat	346..368	CDD:275380	3/10 (30%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		leucine-rich repeat	441..486	CDD:275380	14/44 (32%)
		PPP1R42	472..617	CDD:455733	49/151 (32%)
		leucine-rich repeat	487..507	CDD:275380	8/21 (38%)
		leucine-rich repeat	510..532	CDD:275380	10/21 (48%)
		leucine-rich repeat	556..578	CDD:275380	10/21 (48%)
		leucine-rich repeat	603..626	CDD:275380	7/25 (28%)