Protein Alignment ics and f-cup

DIOPT Version :10

• Sequence 1: NP_609665.2
• Gene: ics / 34774
• FlyBaseID: FBgn0028546
• Length: 283
• Species: Drosophila melanogaster
• Sequence 2: NP_001262544.1
• Gene: f-cup / 41677
• FlyBaseID: FBgn0028487
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 292
• Identity: 85/292 - (29%)
• Similarity: 135/292 - (46%)
• Gaps: 67/292 - (22%)

  Fly    30 LDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLEILNLSNNQLTELPVSLSS 94
            |||:...|:...  |.:.|:.::|.|||..|.:..:.|.|..|..|..||:|:|:|::||.::.|
  Fly   161 LDLSSNTLTHIS--PKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYS 223

  Fly    95 MPKLRILNVSINRLI-----------------------NLPRGFGAFPVLEVLDLSYNNLNEQVL 136
            :|:||.||:|.|..:                       :||.|.|....|..|.|.||::.|  |
  Fly   224 LPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKE--L 286

  Fly   137 PGNFFGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNR 201
            |.:...|.:|:.:.|..||...:|:::|.|:.|..|.|:.||:||||...|: ..|.|||..||.
  Fly   287 PPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGN-EALNELHASNNF 350

  Fly   202 LQVLP-------PEIAQLDLLSNKSVMKMEE-------------NPWVN--PIAEQYLLGISHVI 244
            ::::|       |.:..|||..||.....:|             |..::  |:.   |..::|:|
  Fly   351 IKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVT---LSSLAHLI 412

  Fly   245 --------------DYLKTETYKIIYNRHLQA 262
                          |.|:..|.:|:...|.:|
  Fly   413 SLQVEGNPIKTIRRDILQCGTTRILKTLHDRA 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_609665.2	leucine-rich repeat	29..51	CDD:275380	6/20 (30%)
		LRR	<31..>208	CDD:443914	66/206 (32%)
		leucine-rich repeat	52..84	CDD:275380	12/31 (39%)
		leucine-rich repeat	98..120	CDD:275380	10/44 (23%)
		leucine-rich repeat	121..145	CDD:275380	9/23 (39%)
		leucine-rich repeat	146..168	CDD:275380	7/21 (33%)
		leucine-rich repeat	169..191	CDD:275380	10/21 (48%)
f-cup	NP_001262544.1	LRR	98..428	CDD:443914	79/274 (29%)
		leucine-rich repeat	111..140	CDD:275380
		leucine-rich repeat	158..180	CDD:275380	6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	8/21 (38%)
		leucine-rich repeat	204..226	CDD:275380	9/21 (43%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	4/21 (19%)
		leucine-rich repeat	273..295	CDD:275380	9/23 (39%)
		leucine-rich repeat	296..318	CDD:275380	7/21 (33%)
		leucine-rich repeat	319..340	CDD:275380	10/21 (48%)
		leucine-rich repeat	341..364	CDD:275380	7/22 (32%)
		leucine-rich repeat	389..410	CDD:275380	3/23 (13%)
		leucine-rich repeat	411..430	CDD:275380	2/18 (11%)
		leucine-rich repeat	627..650	CDD:275380
		LRR	<629..>778	CDD:443914
		leucine-rich repeat	651..669	CDD:275380
		leucine-rich repeat	697..719	CDD:275380
		leucine-rich repeat	720..743	CDD:275380
		leucine-rich repeat	744..766	CDD:275380