DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ics and Rsu1

DIOPT Version :9

Sequence 1:	NP_001285902.1	Gene:	ics / 34774	FlyBaseID:	FBgn0028546	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_033131.2	Gene:	Rsu1 / 20163	MGIID:	103040	Length:	277	Species:	Mus musculus

Alignment Length:	272	Identity:	159/272 - (58%)
Similarity:	211/272 - (77%)	Gaps:	6/272 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MSKA-KKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNL 75
            |||: ||:::|:||.:.||:|::|:|:||..::.|||::::||:|.|||||::.:.|.:|.|.||
Mouse     1 MSKSLKKLVEESREKNQPEVDMSDRGISSMLDVNGLFSLAHITQLVLSHNKLTTVPPNVAELKNL 65

  Fly    76 EILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNF 140
            |:||..|||:.|||..:||:.||:.||:.:|||..||||||:.|.||||||:||||||..|||||
Mouse    66 EVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLNEHSLPGNF 130

  Fly   141 FGMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVL 205
            |.:.|||||||.|||||.:|.::|:|..||||.||||||:.||:|:|:|.:|:|||||.|||.||
Mouse   131 FYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVL 195

  Fly   206 PPEIAQLDLLSNKSVMKMEENPWVNPIAEQYLLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPP 270
            |||:..|||...|.|.|.|.||||.|||:|:.||:|||.:|:::||||.:|.||:||   .|.||
Mouse   196 PPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFEYIRSETYKYLYGRHMQA---NPEPP 257

  Fly   271 KA--DKSKKASR 280
            |.  |||||.||
Mouse   258 KKNNDKSKKISR 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_001285902.1	leucine-rich repeat	29..51	CDD:275380	9/21 (43%)
		leucine-rich repeat	52..84	CDD:275380	17/31 (55%)
		LRR_8	96..156	CDD:290566	41/59 (69%)
		leucine-rich repeat	98..120	CDD:275380	12/21 (57%)
		LRR	119..>222	CDD:227223	68/102 (67%)
		leucine-rich repeat	121..145	CDD:275380	18/23 (78%)
		leucine-rich repeat	146..168	CDD:275380	14/21 (67%)
		leucine-rich repeat	169..191	CDD:275380	15/21 (71%)
Rsu1	NP_033131.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		11/21 (52%)
		leucine-rich repeat	19..41	CDD:275380	9/21 (43%)
		LRR	<38..>202	CDD:227223	100/163 (61%)
		LRR 1	41..63		10/21 (48%)
		leucine-rich repeat	42..64	CDD:275380	11/21 (52%)
		LRR 2	64..85		12/20 (60%)
		leucine-rich repeat	65..87	CDD:275380	12/21 (57%)
		LRR 3	87..108		13/20 (65%)
		leucine-rich repeat	88..110	CDD:275380	12/21 (57%)
		LRR 4	110..133		18/22 (82%)
		leucine-rich repeat	111..135	CDD:275380	18/23 (78%)
		LRR 5	135..156		14/20 (70%)
		leucine-rich repeat	136..158	CDD:275380	14/21 (67%)
		LRR 6	158..179		14/20 (70%)
		leucine-rich repeat	159..181	CDD:275380	15/21 (71%)
		LRR 7	181..202		14/20 (70%)
		leucine-rich repeat	182..207	CDD:275380	17/24 (71%)
		leucine-rich repeat	208..227	CDD:275380	12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..277		13/23 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837053
Domainoid	1	1.000	42	1.000	Domainoid score	I12433
eggNOG	1	0.900	-	-		E2759_KOG0617
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7521
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2453
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52835
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006365
OrthoInspector	1	1.000	-	-		oto93242
orthoMCL	1	0.900	-	-		OOG6_105610
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3641
SonicParanoid	1	1.000	-	-		X4633
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790