DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ics and rsu-1

DIOPT Version :9

Sequence 1:	NP_001285902.1	Gene:	ics / 34774	FlyBaseID:	FBgn0028546	Length:	283	Species:	Drosophila melanogaster
Sequence 2:	NP_497716.1	Gene:	rsu-1 / 175451	WormBaseID:	WBGene00007924	Length:	268	Species:	Caenorhabditis elegans

Alignment Length:	270	Identity:	145/270 - (53%)
Similarity:	195/270 - (72%)	Gaps:	9/270 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 MSKAKKVLDEARETHNPELDLADKGLSSFEELPGLFNMSNITRLTLSHNKISVISPGIANLLNLE 76
            |.|.|| .||..|..:     .|:.:|||.::..|.:...||||||||||::.:.|.||:|::|:
Worm     1 MPKDKK-KDEVTEVEH-----VDRNISSFSQISHLIDAEIITRLTLSHNKLTSVPPNIADLVSLQ 59

  Fly    77 ILNLSNNQLTELPVSLSSMPKLRILNVSINRLINLPRGFGAFPVLEVLDLSYNNLNEQVLPGNFF 141
            .|||.|||:.:||.|:||:||||||||.:|:|..||||||:||.||:|||:||||:|:.||||||
Worm    60 SLNLWNNQIEDLPPSISSLPKLRILNVGMNKLSILPRGFGSFPELEILDLTYNNLSERSLPGNFF 124

  Fly   142 GMETLRALYLGDNDFEYIPKEVGQLKNLQILGLRDNDLLELPREVGDLVRLRELHIQNNRLQVLP 206
            .|:|||||||||||||.:|.:|..|.|||||.||:||||.||:|:|.|.||||||||.|||.::|
Worm   125 FMQTLRALYLGDNDFEMLPGDVENLTNLQILVLRENDLLTLPKELGKLTRLRELHIQGNRLAMIP 189

  Fly   207 PEIAQLDLLSNKSVMKMEENPWVNPIAEQY-LLGISHVIDYLKTETYKIIYNRHLQAGRSGPPPP 270
            ||:..|:|:.:|.|:::|.||::..|.||: ..|.:.|..:::|:.|:..:.|  |...|.|.||
Worm   190 PELGNLELVGSKQVLRLEHNPFIPRIEEQFEANGAAGVWAHIRTDDYRYFFGR--QEPSSTPVPP 252

  Fly   271 KADKSKKASR 280
            |.:|.||.||
Worm   253 KRNKEKKVSR 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ics	NP_001285902.1	leucine-rich repeat	29..51	CDD:275380	5/21 (24%)
		leucine-rich repeat	52..84	CDD:275380	19/31 (61%)
		LRR_8	96..156	CDD:290566	45/59 (76%)
		leucine-rich repeat	98..120	CDD:275380	15/21 (71%)
		LRR	119..>222	CDD:227223	68/102 (67%)
		leucine-rich repeat	121..145	CDD:275380	17/23 (74%)
		leucine-rich repeat	146..168	CDD:275380	15/21 (71%)
		leucine-rich repeat	169..191	CDD:275380	15/21 (71%)
rsu-1	NP_497716.1	LRR_4	35..73	CDD:289563	22/37 (59%)
		leucine-rich repeat	36..57	CDD:275380	13/20 (65%)
		LRR_RI	<53..164	CDD:238064	75/110 (68%)
		LRR_8	57..114	CDD:290566	37/56 (66%)
		LRR_4	57..95	CDD:289563	22/37 (59%)
		leucine-rich repeat	58..80	CDD:275380	12/21 (57%)
		leucine-rich repeat	81..103	CDD:275380	15/21 (71%)
		leucine-rich repeat	104..128	CDD:275380	17/23 (74%)
		LRR_8	128..185	CDD:290566	41/56 (73%)
		leucine-rich repeat	129..151	CDD:275380	15/21 (71%)
		LRR_4	150..190	CDD:289563	27/39 (69%)
		leucine-rich repeat	152..174	CDD:275380	15/21 (71%)
		leucine-rich repeat	175..200	CDD:275380	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159270
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0617
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7521
Inparanoid	1	1.050	275	1.000	Inparanoid score	I1784
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52835
OrthoDB	1	1.010	-	-		D1382533at2759
OrthoFinder	1	1.000	-	-		FOG0006365
OrthoInspector	1	1.000	-	-		oto20298
orthoMCL	1	0.900	-	-		OOG6_105610
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3641
SonicParanoid	1	1.000	-	-		X4633
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.840