Protein Alignment TUBB2B and alphaTub84B

DIOPT Version :10

• Sequence 1: NP_821080.1
• Gene: TUBB2B / 347733
• HGNCID: 30829
• Length: 445
• Species: Homo sapiens
• Sequence 2: NP_476772.1
• Gene: alphaTub84B / 40848
• FlyBaseID: FBgn0003884
• Length: 450
• Species: Drosophila melanogaster
• Alignment Length: 449
• Identity: 179/449 - (39%)
• Similarity: 270/449 - (60%)
• Gaps: 10/449 - (2%)

Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDL--QLERINVYYNEATGNKYVPRA 63
            |||.:.|..||.|.|||...||:...||||.|.|....|..:  ..:..|.:::|....|:||||
  Fly     1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRA 65

Human    64 ILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCD 128
            :.|||||..:|.||:|.:.|:|.|:..:.|:..|.||:|:||||.|.|:||.|||.:||.::.|.
  Fly    66 VFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCT 130

Human   129 CLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLV 193
            .||||.:.||.|||||||..:||:.::..:|..:....|::.|:|:||..||||||:.|:.|..:
  Fly   131 GLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTL 195

Human   194 ENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMV 258
            |::|..:.:||||:||||.|.|.:..|||.:||.|:...:|.:|..|||.|.||.||.:...|:|
  Fly   196 EHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV 260

Human   259 PFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSM 323
            |:||:||.:..:||:.|.....:..|:|.|:|...|:..|.|..||||||:|:....::||.:..
  Fly   261 PYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYRGDVVP 325

Human   324 KEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP--------RGLKMSATFIGNSTAIQELFKR 380
            |:|:..:..::.|.:..||:|.|...|..:...||        ..::.:...:.|:|||.|.:.|
  Fly   326 KDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWAR 390

Human   381 ISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEE 439
            :..:|..|:.::||:|||.||||:|.||:||..::..|..:|::....:.|.:||..||
  Fly   391 LDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGMDSGDGEGEGAEE 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB2B	NP_821080.1	PLN00220	1..430	CDD:215107	174/438 (40%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..445		6/18 (33%)
alphaTub84B	NP_476772.1	PTZ00335	1..439	CDD:185562	174/437 (40%)