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Protein Alignment TUBB2B and gammaTub37C

DIOPT Version :10

Sequence 1:	NP_821080.1	Gene:	TUBB2B / 347733	HGNCID:	30829	Length:	445	Species:	Homo sapiens
Sequence 2:	NP_476922.1	Gene:	gammaTub37C / 35199	FlyBaseID:	FBgn0010097	Length:	457	Species:	Drosophila melanogaster

Alignment Length:	439	Identity:	151/439 - (34%)
Similarity:	257/439 - (58%)	Gaps:	23/439 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     3 EIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVD 67
            ||:.:|.||||||||.:||:.:..||||.|.|.....:....:|.:|::.:|..|.|:|||:|:|
  Fly     4 EIITLQLGQCGNQIGFEFWKRLCLEHGISPDGVLEDFATDGQDRKDVFFYQADDNHYIPRAVLID 68

Human    68 LEPGTMDSVRSGPFGQIFRPDNFVFGQ--SGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCL 130
            |||..::::.:.|:.:::..:|....:  .|||||||.| :::|.::.:.|.|::.:|::..|.|
  Fly    69 LEPRVINNIMTSPYSKLYNQENVFLSKHGGGAGNNWASG-FSQGEKVQEEVFDILDREADGSDSL 132

Human   131 QGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPS-PKVSDTVVEPYNATLSVHQLVE 194
            :||.|.||:.||||||||:.::.::.|.:|.:::.|:||.|: .::||.||:|||:.|::.:|.:
  Fly   133 EGFVLCHSIAGGTGSGMGSYVLERLSERFPKKLIQTYSVFPNQDEISDVVVQPYNSILTLKRLTK 197

Human   195 NTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVP 259
            ..|....:||.||..|....|.:.|||:..:|:|||..||..||.||:|..:|.:|..|..:::|
  Fly   198 CADSVVVLDNTALNRIATERLHIQTPTFTQINNLVSTIMSLSTTTLRYPSYMNNNLIGLTASLIP 262

Human   260 FPRLHFFMPGFAPLTS--RGSQQYRALTVPELTQQMFDSKNMM-AACDPRHGR--YLTVAAIFRG 319
            .|:|||.|.|:.||.|  ......|..||.::.:::...|||| :|...:..|  ::::..|.:|
  Fly   263 TPQLHFLMTGYTPLMSDCETKTSVRKTTVLDVMRRLLQPKNMMVSALTDKQSRQCFVSILNIIQG 327

Human   320 RMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGL-------KMSATFIGNSTAIQEL 377
            .:...:|.:.:..::.:..:.|:.|.|.:::.|:    ||..       |:|...:.|.|.|..|
  Fly   328 EVDPSQVHKSLQRIRERKLANFIPWGPASIQVAL----PRSSPYVQSAHKVSGLMMANHTGISSL 388

Human   378 FKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTE---AESNMNDLVSEYQ 423
            |||...|:..:.:|.|||..:..|.|.:.:.||   |...::.||.||:
  Fly   389 FKRALAQYDKLRKRNAFLDNFRRESMFQDDLTELDIARDTVDCLVQEYE 437

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.