Protein Alignment TUBB2B and betaTub65B

DIOPT Version :10

• Sequence 1: NP_821080.1
• Gene: TUBB2B / 347733
• HGNCID: 30829
• Length: 445
• Species: Homo sapiens
• Sequence 2: NP_729172.1
• Gene: betaTub65B / 117406
• FlyBaseID: FBgn0052396
• Length: 462
• Species: Drosophila melanogaster
• Alignment Length: 455
• Identity: 244/455 - (53%)
• Similarity: 319/455 - (70%)
• Gaps: 14/455 - (3%)

Human     1 MREIVHIQAGQCGNQIGAKFWEVISDEHGID-PTGSYHGDSDLQLERINVYYNEATGNKYVPRAI 64
            |||||.:|.|..||.||..||.|||.|||:| .:|.:.|.|.||||||||::|.....::..|.|
  Fly     1 MREIVTLQIGGAGNAIGDSFWHVISHEHGVDYASGRFGGTSPLQLERINVFFNATASKRFYARTI 65

Human    65 LVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDC 129
            |:|.|..|:..:.:.  .|::||:|||.|...||||:|:|::|:||.::|.||:..|:|.||.|.
  Fly    66 LIDTEASTIQRLNAS--SQLYRPENFVAGSESAGNNFARGYHTDGAAILDQVLENTRREVESVDS 128

Human   130 LQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVE 194
            ||||||.||:|||||||:.:|::..:.|:|||.::..:..:|||.:|..|||||||.||...||.
  Fly   129 LQGFQLLHSIGGGTGSGLTSLIMEALVEQYPDNLLCNYVTIPSPNMSQVVVEPYNALLSTPALVN 193

Human   195 NTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVP 259
            |:..|:|:|||||:.||.|.|||....|..:||:|:.||||:||||||||||||.|||:.|||||
  Fly   194 NSHLTFCLDNEALFQICNRNLKLKMSGYEHINHIVALTMSGITTCLRFPGQLNAGLRKIYVNMVP 258

Human   260 FPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMK 324
            ||||||.:||||||.:...||:...||.||.||:|.|.|::.|.|.|.|:.||.|.|||||||.:
  Fly   259 FPRLHFLIPGFAPLVTCKQQQFSKGTVSELVQQIFYSNNLLCAIDLRKGKLLTAAGIFRGRMSPR 323

Human   325 EVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMF 389
            |||:.|..|:|||.:.||:|||||:|||:|||||||||||||||||:||||.||:|:.:...:|.
  Fly   324 EVDQLMTGVRNKNINNFVDWIPNNIKTAICDIPPRGLKMSATFIGNTTAIQTLFQRLLDASMSML 388

Human   390 RRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQG---------EFEEEEGEDEA 445
            ||||.|||||||||:|.||.:|:..:..::.:|:  ..|..::.|         ....|.||:||
  Fly   389 RRKAHLHWYTGEGMEEQEFQDAQQELQAIIDDYR--SSAEGEDSGGGGGGGGGRSGSAESGEEEA 451

Human   446  445
              Fly   452  451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TUBB2B	NP_821080.1	PLN00220	1..430	CDD:215107	238/429 (55%)
		MREI motif. /evidence=ECO:0000250|UniProtKB:P07437	1..4		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..445		6/31 (19%)
betaTub65B	NP_729172.1	beta_tubulin	2..425	CDD:276956	236/426 (55%)