DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9254 and SLC17A6

DIOPT Version :9

Sequence 1:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_065079.1	Gene:	SLC17A6 / 57084	HGNCID:	16703	Length:	582	Species:	Homo sapiens

Alignment Length:	469	Identity:	149/469 - (31%)
Similarity:	239/469 - (50%)	Gaps:	26/469 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 FVLPQRWILAIMGFFAIFNAYTMRICLSQAITVLVVKRNYTIFHTEAICEPDDQSDPSSTFEGGD 82
            |.||:|:|:|||.......::.:|..|..||..:|  .|.||.....:.:           |...
Human    65 FGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMV--NNSTIHRGGKVIK-----------EKAK 116

  Fly    83 YDWSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPVC--IVYGGAD 145
            ::|..|..|:|..||:.|||:|.:|||.:|.:..........|..|:...:|.|..  :.||
Human   117 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYG--- 178

  Fly   146 ALIVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGYVLSSMDWP 210
            .:|.:|:|.||.||.|:||...:.:.|.|..||..|......|...|::....::|.::....|.
Human   179 CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWS 243

  Fly   211 WVFYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFLAQEVPPPDK-----NKPKTPFFAILT 270
            .||||:....:||::.:.||.:.||..||.|..|||.::.:.:.....     .|.|||:....|
Human   244 SVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFT 308

  Fly   271 SIPMWALISAQIGHDWGFYIMVSYLPKYMSDVLRFSIKSNGLYSSLPYVTMWIMSLLSGCVADQM 335
            |:|::|:|.|.....|.||:::...|.|..:|..|.|...|:.|::|::.|.|:..:.|.:||.:
Human   309 SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFL 373

  Fly   336 IKRNCMSTTNTRKIMTGVAAFG-PAVFMVAASYAGCNRGMVVALFTITMGLMGTYYAGMKLTPLD 399
            ..:..:|||..|||| ....|| .|..::...|:. .||:.::...:.:|..|...:|..:..||
Human   374 RSKQILSTTTVRKIM-NCGGFGMEATLLLVVGYSH-TRGVAISFLVLAVGFSGFAISGFNVNHLD 436

  Fly   400 MSPNYAGTLMAITNGIGAITGVVSPYLVGVMTPNATLLEWRLVFWVAFGVLVVTAIVYCIWASGD 464
            ::|.||..||.|:||:|.::|:|.|.:||.||.|.:..||:.||.:|..|.....|.|.|:|||:
Human   437 IAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYAIFASGE 501

  Fly   465 VQPFNDGTNSNKKK 478
            .||:.|...::::|
Human   502 KQPWADPEETSEEK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	139/445 (31%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	125/386 (32%)
SLC17A6	NP_065079.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	137/441 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740