DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9254 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	140/466 - (30%)
Similarity:	239/466 - (51%)	Gaps:	25/466 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LPQRWILAIMGFFAIFNAYTMRICLSQAITVLVVKRNYTIFHTEAICEPDDQSDPSSTFEGGDYD 84
            :|:|:|:|:|.......::.:|..|..||..:|  .|.|::           .|.....:...::
  Rat    72 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMV--NNSTVY-----------VDGKPEIQTAQFN 123

  Fly    85 WSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPVC--IVYGGADAL 147
            |..|..|||..||:.|||||.:|||.:::||.........||.|:...:..|..  :.||   .:
  Rat   124 WDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG---CV 185

  Fly   148 IVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGYVLSSMDWPWV 212
            :.:|:|.||.||.|:||...:.:.|.|..||..|......|...|::....::|.::..:.|..|
  Rat   186 MCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASV 250

  Fly   213 FYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFLAQEVPP----PDKNKPKTPFFAILTSIP 273
            ||::.:..::|::.:.|..:..|..||.|..|||.::...:..    ...:|..||:....||:|
  Rat   251 FYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLP 315

  Fly   274 MWALISAQIGHDWGFYIMVSYLPKYMSDVLRFSIKSNGLYSSLPYVTMWIMSLLSGCVADQMIKR 338
            ::|:|.|.....|.||:::...|.|..:|..|:|...||.|::|::.|.|:..:.|.:||.:..|
  Rat   316 VYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSR 380

  Fly   339 NCMSTTNTRKIMTGVAAFG-PAVFMVAASYAGCNRGMVVALFTITMGLMGTYYAGMKLTPLDMSP 402
            ..::||..|||| ....|| .|..::...::. .:|:.::...:.:|..|...:|..:..||::|
  Rat   381 KILTTTAVRKIM-NCGGFGMEATLLLVVGFSH-TKGVAISFLVLAVGFSGFAISGFNVNHLDIAP 443

  Fly   403 NYAGTLMAITNGIGAITGVVSPYLVGVMTPNATLLEWRLVFWVAFGVLVVTAIVYCIWASGDVQP 467
            .||..||.|:||:|.::|:|.|.:||.||.:.|..||:.||.:|..|.....|.|.::|||:.|.
  Rat   444 RYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQD 508

  Fly   468 FNDGTNSNKKK 478
            :.|..|.:::|
  Rat   509 WADPENLSEEK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	132/444 (30%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	120/385 (31%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	130/440 (30%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740