DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9254 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	423	Identity:	162/423 - (38%)
Similarity:	240/423 - (56%)	Gaps:	10/423 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RWILAIMGFFAIFNAYTMRICLSQAITVLVVKRNYTI--FHTEAICEPDDQSDPSSTFE---GGD 82
            |:.|||:.||..|..|.:|:.||.|: |.:|..|.|:  ..|...|  .:.|.|.....   |..
Human    39 RYNLAILAFFGFFIVYALRVNLSVAL-VDMVDSNTTLEDNRTSKAC--PEHSAPIKVHHNQTGKK 100

  Fly    83 YDWSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPVCIVYGGADAL 147
            |.|..|.||.||.||:.|||:|.:|||.:|.|.|||..|..||..||:.||.||:.... |...|
Human   101 YQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADL-GVGPL 164

  Fly   148 IVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGYVLSSMDWPWV 212
            ||||.|.|||||.||||:..:.:||.|..||..|.::...|.|:|::....:||.:...|:|.:|
Human   165 IVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYV 229

  Fly   213 FYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFLAQEVPPPDKNKPKTPFFAILTSIPMWAL 277
            ||.|..|.:.||:::..:...:|..|..|...|:.::...:.....::...|:..||.|:|:||:
Human   230 FYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAI 294

  Fly   278 ISAQIGHDWGFYIMVSYLPKYMSDVLRFSIKSNGLYSSLPYVTMWIMSLLSGCVADQMIKRNCMS 342
            :.|...::|.||.:::.||.||.::|||:::.||..|||||:..|:..:|||..||.:..:...|
Human   295 VVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFS 359

  Fly   343 TTNTRKIMTGVAAFGPAVFMVAASYAGCNRGMVVALFTITMGLMGTYYAGMKLTPLDMSPNYAGT 407
            |...|:|.:.:...|||||:|||.:.||:..:.||..||:..|.|...:|..:..||::|:|||.
Human   360 TLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGI 424

  Fly   408 LMAITNGIGAITGVVSPYLVGVMTPNATLLEWR 440
            |:.|||....|.|:|.|.:...:||:|. ::||
Human   425 LLGITNTFATIPGMVGPVIAKSLTPDAG-VQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	159/418 (38%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	141/359 (39%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	161/420 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840