DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9254 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_609664.1	Gene:	CG9254 / 34773	FlyBaseID:	FBgn0028513	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	466	Identity:	140/466 - (30%)
Similarity:	239/466 - (51%)	Gaps:	25/466 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LPQRWILAIMGFFAIFNAYTMRICLSQAITVLVVKRNYTIFHTEAICEPDDQSDPSSTFEGGDYD 84
            ||:|:|:|||.......::.:|..|..||..:|  .|.|::           .|.....:...::
Human    72 LPKRYIIAIMSGLGFCISFGIRCNLGVAIVEMV--NNSTVY-----------VDGKPEIQTAQFN 123

  Fly    85 WSQEKQGLILASFYIGYIVTHLPGGILADKFGGKWTLSLGIFFTAIFTLLTPVC--IVYGGADAL 147
            |..|..|||..||:.|||:|.:|||.:::||.........||.|:...:..|..  :.||   .:
Human   124 WDPETVGLIHGSFFWGYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG---CV 185

  Fly   148 IVLRVLMGLGEGTTFPALSVLLASWVPANERGMLGALVLGGGQMGSIAGNIISGYVLSSMDWPWV 212
            :.:|:|.||.||.|:||...:.:.|.|..||..|......|...|::....::|.::..:.|..|
Human   186 MCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWSSV 250

  Fly   213 FYVFAIIALVWFVVFTLVCFSSPFTHPYIKPEERAFLAQEVPP----PDKNKPKTPFFAILTSIP 273
            ||::.:..::|::.:.|..:..|..||.|..||:.::...:..    ...:|..||:....||:|
Human   251 FYIYGMFGIIWYMFWLLQAYECPAAHPTISNEEKTYIETSIGEGANVVSLSKFSTPWKRFFTSLP 315

  Fly   274 MWALISAQIGHDWGFYIMVSYLPKYMSDVLRFSIKSNGLYSSLPYVTMWIMSLLSGCVADQMIKR 338
            ::|:|.|.....|.||:::...|.|..:|..|:|...||.|::|::.|.|:..:.|.:||.:..|
Human   316 VYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSR 380

  Fly   339 NCMSTTNTRKIMTGVAAFG-PAVFMVAASYAGCNRGMVVALFTITMGLMGTYYAGMKLTPLDMSP 402
            ..::||..|||| ....|| .|..::...::. .:|:.::...:.:|..|...:|..:..||::|
Human   381 QILTTTAVRKIM-NCGGFGMEATLLLVVGFSH-TKGVAISFLVLAVGFSGFAISGFNVNHLDIAP 443

  Fly   403 NYAGTLMAITNGIGAITGVVSPYLVGVMTPNATLLEWRLVFWVAFGVLVVTAIVYCIWASGDVQP 467
            .||..||.|:||:|.::|:|.|.:||.||.:.|..||:.||.:|..|.....|.|.::|||:.|.
Human   444 RYASILMGISNGVGTLSGMVCPLIVGAMTRHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQE 508

  Fly   468 FNDGTNSNKKK 478
            :.|..|.:::|
Human   509 WADPENLSEEK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9254	NP_609664.1	2A0114euk	28..466	CDD:129972	131/444 (30%)
CG9254	NP_609664.1	MFS	82..461	CDD:119392	118/385 (31%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	136/455 (30%)
		MFS	80..502	CDD:119392	128/439 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148616
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740