DRSC/TRiP Functional Genomics Resources

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Protein Alignment kuz and ADAMTS3

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_055058.2 Gene:ADAMTS3 / 9508 HGNCID:219 Length:1205 Species:Homo sapiens


Alignment Length:1477 Identity:259/1477 - (17%)
Similarity:408/1477 - (27%) Gaps:618/1477 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 YISHYETLNYDHEHIRASHNRARRSVTKD-QYVHLKFASHGRDFHLRLKRDLNTFSNKLDFYDSK 103
            |:||  ||:..|:      .|:.|.|:.: :.:.....:.|:|||||||                
Human    56 YLSH--TLSASHK------KRSARDVSSNPEQLFFNITAFGKDFHLRLK---------------- 96

  Fly   104 GPIDVSTDHIYEGEVI-GDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPS 167
                .:|..:..|.|: ....|.|.|:|                                |.|.:
Human    97 ----PNTQLVAPGAVVEWHETSLVPGNI--------------------------------TDPIN 125

  Fly   168 TSTTSSATTATKSTQPTR---------------PLAKSNTSTTAVNSKTENFIKKIAESTTTSQQ 217
            .....|||...:.|:|.:               .:|.||....|...|::|              
Human   126 NHQPGSATYRIRRTEPLQTNCAYVGDIVDIPGTSVAISNCDGLAGMIKSDN-------------- 176

  Fly   218 LPEYTESSSSSTTTFPPTTEYFED--EKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGI 280
                              .|||.:  |:.:..|:|.....::||                     
Human   177 ------------------EEYFIEPLERGKQMEEEKGRIHVVYK--------------------- 202

  Fly   281 TDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQ 345
                        .||||:.|..||||:                    |..:..:.|.:|.     
Human   203 ------------RSAVEQAPIDMSKDF--------------------HYRESDLEGLDDL----- 230

  Fly   346 KYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKN 410
                      |..|           .|:   ||.::|.:||....|              |::.|
Human   231 ----------GTVY-----------GNI---HQQLNETMRRRRHAG--------------ENDYN 257

  Fly   411 TCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEH 475
            ...|....|.::..|                   .:|.:.:.:...:..||.||.:       |.
Human   258 IEVLLGVDDSVVRFH-------------------GKEHVQNYLLTLMNIVNEIYHD-------ES 296

  Fly   476 RNIRFEVQRIK------------IDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCL 528
            ..:...|..::            |:..:..|:..|....|...:..|    ||.....||:.|  
Human   297 LGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSD----LNHSEHHDHAIF-- 355

  Fly   529 AYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV 593
               .|.:||  |..|:...|..:    |:|...::.|                     :|:....
Human   356 ---LTRQDF--GPAGMQGYAPVT----GMCHPVRSCT---------------------LNHEDGF 390

  Fly   594 PPKVSQLTLAHEIGHNFGSPHD-----YPQECRPGGLNGNYIMFA------SATSG--------- 638
            .   |...:|||.||..|..||     ...|...|.:....:..|      |..||         
Human   391 S---SAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHS 452

  Fly   639 -----DRP--------------NNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGA-------- 676
                 |.|              |.|....|.       .|..||......|:..:..        
Human   453 YDCLLDDPFDHDWPKLPELPGINYSMDEQCR-------FDFGVGYKMCTAFRTFDPCKQLWCSHP 510

  Fly   677 ----FCGNKIVE--SGEECDCGFNEEECKDKCCYP-----RLISEYDQSLN----SSAKGCTRRA 726
                ||..|...  .|.||..|        |.||.     :..::..|..|    :....|:|..
Human   511 DNPYFCKTKKGPPLDGTECAAG--------KWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTC 567

  Fly   727 KT-------QCS---PSQGPCCLSNSCTFVPTSYH----QKCKEETECSWSSTCNGTTA------ 771
            .|       ||:   |..|    ...|..|...|.    ::|::..|...:..|....:      
Human   568 GTGVRFRTRQCNNPMPING----GQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQN 628

  Fly   772 --------ECPEPRHRDD--------------KTMCNNGT--------ALCIRGECSGSPCLLWN 806
                    |.|:|:.|..              |.:.::||        ::|:||||....|    
Human   629 TKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGC---- 689

  Fly   807 MTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYC 871
                      ...:...|:.|.....|.|.|.||:.          ||..:..|..     .||.
Human   690 ----------DKEIGSNKVEDKCGVCGGDNSHCRTV----------KGTFTRTPRK-----LGYL 729

  Fly   872 DVF--------LKCRAVDADGPLLRLKN-----LLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVV 923
            .:|        :..:..:|...:|.:||     .:||.|..:..:...:|       :||.:...
Human   730 KMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFID-------LGVEWDYN 787

  Fly   924 MGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHE------ 982
            :...|:  ::||..             .|..|:..|...|.:..:.....:.|   .||      
Human   788 IEDDIE--SLHTDG-------------PLHDPVIVLIIPQENDTRSSLTYKYI---IHEDSVPTI 834

  Fly   983 ----------------AQHYSRGGDGRGGG----GGGGGRHGGSRSHHQQ--------------- 1012
                            .:.:|:.....|||    ..|..|...::..|:.               
Human   835 NSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMC 899

  Fly  1013 ------HP----HDWDR-----HQGGHS------IVPLPTGGSHSSRNSAA----NQARRSDGR- 1051
                  ||    .:|:.     ...|:.      :.||..|.:.|..:...    .::||...| 
Human   900 NIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRV 964

  Fly  1052 --------GPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGG------------GVQ 1096
                    ||.|..|     :..|.|..........|...:...|.|:..            |.:
Human   965 PCPAQWKTGPWSECS-----VTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDK 1024

  Fly  1097 AAISSGGVVAR-AQLP--------------LPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAF 1146
            :......|:|| ..:|              ..||||...:..:....: :..|:..|:.......
Human  1025 SIFCQMEVLARYCSIPGYNKLCCESCSKRSSTLPPPYLLEAAETHDDV-ISNPSDLPRSLVMPTS 1088

  Fly  1147 YTP--KELPPRNKSRSS-------------RTNNTSNTTTTTNSSTAAAGSGSV-------SGPG 1189
            ..|  .|.|.:..|.||             |.|:..:.......|...|||.:|       |.|.
Human  1089 LVPYHSETPAKKMSLSSISSVGGPNAYAAFRPNSKPDGANLRQRSAQQAGSKTVRLVTVPSSPPT 1153

  Fly  1190 SGAGSSSKSKSGKSA--KAKDSKSQKSQQANNSRSSSKEKGVKPVRR 1234
            .....||.|:...::  .|.||....||    :|:|.|:..:...||
Human  1154 KRVHLSSASQMAAASFFAASDSIGASSQ----ARTSKKDGKIIDNRR 1196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 55/329 (17%)
Reprolysin_2 450..659 CDD:290307 46/259 (18%)
Disintegrin 684..776 CDD:278623 24/130 (18%)
ADAMTS3NP_055058.2 Pep_M12B_propep 66..200 CDD:279848 37/223 (17%)
ZnMc_ADAMTS_like 256..457 CDD:239801 46/265 (17%)
Reprolysin 258..460 CDD:279729 46/266 (17%)
TSP1 554..605 CDD:214559 10/54 (19%)
Spacer 713..844 27/170 (16%)
ADAM_spacer1 713..827 CDD:283607 25/153 (16%)
TSP1 848..904 CDD:214559 7/55 (13%)
TSP1 912..967 CDD:214559 9/54 (17%)
TSP1 970..1015 CDD:214559 9/49 (18%)
PLAC 1023..1051 CDD:285849 4/27 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1174..1205 9/27 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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