Protein Alignment kuz and ADAM18

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_055052.1
• Gene: ADAM18 / 8749
• HGNCID: 196
• Length: 739
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 113/479 - (23%)
• Similarity: 160/479 - (33%)
• Gaps: 165/479 - (34%)

  Fly   561 YKTYTETVGGQYQST--KRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPG 623
            |:.:.:.||..:..|  .:|.:.||   ..|...:..:...:.:|..:|.|.|..:|...:|  .
Human   277 YRKHPKYVGATFPGTVCNKSYDAGI---AMYPDAIGLEGFSVIIAQLLGLNVGLTYDDITQC--F 336

  Fly   624 GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKA--------SEGAFCGN 680
            .|....||...|.|..  ....||.||:.:..    ..|...:..|.:.        .....|||
Human   337 CLRATCIMNHEAVSAS--GRKIFSNCSMHDYR----YFVSKFETKCLQKLSNLQPLHQNQPVCGN 395

  Fly   681 KIVESGEECDCGFNEEECK-DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSN--- 741
            .|:||.|||||| |:.||: .|||      :|:.        |..:...:|  ..||||.|.
Human   396 GILESNEECDCG-NKNECQFKKCC------DYNT--------CKLKGSVKC--GSGPCCTSKCEL 443

  Fly   742 SCTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC------- 797
            |....|      |::  :.||.::..||||::.|....:..:..:|..|||.|..|:|
Human   444 SIAGTP------CRKSIDPECDFTEYCNGTSSNCVPDTYALNGRLCKLGTAYCYNGQCQTTDNQC 502

  Fly   798 --------SGSP--C------LLWNMTKC-FLTSTTLPHVSKRKLC-DLAC-------------- 830
                    .|:|  |      |......| |..|..||...|..|| .|||
Human   503 AKIFGKGAQGAPFACFKEVNSLHERSENCGFKNSQPLPCERKDVLCGKLACVQPHKNANKSDAQS 567

  Fly   831 ---------------------QDGNDTS-----------------TCRSTSEFADKYNIQ----- 852
                                 .||.|.:                 |||......  ||..
Human   568 TVYSYIQDHVCVSIATGSSMRSDGTDNAYVADGTMCGPEMYCVNKTCRKVHLMG--YNCNATTKC 630

  Fly   853 KG-GISLQPGSPCDNFQGYCDVFLKCRAVDA------------DGPLLRLKNLLLNRKTLQTVAE 904
            || ||       |:|| |.|..|...|..|.            ||...:..: ....|...|  .
Human   631 KGKGI-------CNNF-GNCQCFPGHRPPDCKFQFGSPGGSIDDGNFQKSGD-FYTEKGYNT--H 684

  Fly   905 WIVDNWYLVVLMGVAFIVVMGSFI 928
            |  :||::     ::|.:.:..||
Human   685 W--NNWFI-----LSFCIFLPFFI 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	25/125 (20%)
		Reprolysin_2	450..659	CDD:290307	23/99 (23%)
		Disintegrin	684..776	CDD:278623	32/97 (33%)
ADAM18	NP_055052.1	Pep_M12B_propep	26..141	CDD:307618
		Reprolysin	184..380	CDD:307535	25/113 (22%)
		DISIN	399..476	CDD:214490	32/99 (32%)
		ACR	478..617	CDD:214743	28/138 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850