DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM21

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_003804.2	Gene:	ADAM21 / 8747	HGNCID:	200	Length:	722	Species:	Homo sapiens

Alignment Length:	403	Identity:	101/403 - (25%)
Similarity:	146/403 - (36%)	Gaps:	151/403 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 LGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEI 606
            ||||:||       |||   :...:.....:|....||      |.|            |:|||:
Human   307 LGLAYVA-------GIC---RPPIDCGVDNFQGDTWSL------FAN------------TVAHEL 343

  Fly   607 GHNFGSPHDYPQE---CRPGGLNGNYIMFASATSGDRPNNSKFSPCS--------------IRNI 654
            ||..|..||  :|   |...|...|..         |....||:.||              :.|.
Human   344 GHTLGMQHD--EEFCFCGERGCIMNTF---------RVPAEKFTNCSYADFMKTTLNQGSCLHNP 397

  Fly   655 SNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSS 718
            ..:.::.:  .||          |||.:||..|:|||| :.::| :|.||.          ||
Human   398 PRLGEIFM--LKR----------CGNGVVEREEQCDCG-SVQQCEQDACCL----------LN-- 437

  Fly   719 AKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDK 782
               ||.|....|  :.|.||  ..|.|:|:.  :.|::| .||.....||||:.:|||.|:..|.
Human   438 ---CTLRPGAAC--AFGLCC--KDCKFMPSG--ELCRQEVNECDLPEWCNGTSHQCPEDRYVQDG 493

  Fly   783 TMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQD--GNDTSTCRSTSEF 845
            ..|:: :|.|.:..|:..                          |..|::  |.|   .:|.|:.
Human   494 IPCSD-SAYCYQKRCNNH--------------------------DQHCREIFGKD---AKSASQN 528

  Fly   846 ADKYNIQKGGISLQPGSPCDNFQGYCDV----FLKCRAVDA-----------DGPLLRLKNLLLN 895
            ..|....:|           |..|:|.:    :|||...|.           |.|||: .:..|.
Human   529 CYKEINSQG-----------NRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQ-DHFTLQ 581

  Fly   896 RKTLQTVAEWIVD 908
            ...:..|..|.:|
Human   582 HTHINGVTCWGID 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	35/151 (23%)
		Reprolysin_2	450..659	CDD:290307	33/133 (25%)
		Disintegrin	684..776	CDD:278623	32/93 (34%)
ADAM21	NP_003804.2	Pep_M12B_propep	50..158	CDD:279848
		Cysteine switch. /evidence=ECO:0000250	171..178
		ZnMc_adamalysin_II_like	208..396	CDD:239797	32/127 (25%)
		Reprolysin	209..398	CDD:279729	33/129 (26%)
		Disintegrin	415..487	CDD:278623	32/93 (34%)
		ACR	491..627	CDD:214743	28/146 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146052
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850