DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kuz and ADAM23

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_003803.1 Gene:ADAM23 / 8745 HGNCID:202 Length:832 Species:Homo sapiens


Alignment Length:873 Identity:195/873 - (22%)
Similarity:284/873 - (32%) Gaps:296/873 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   161 ATTTPPSTSTTSSATTATKSTQPTR---------PLAKSN---------TSTTAVNSKTENFIKK 207
            |:..|......|...:|...|.|.|         |||.|:         .|....|...|..:..
Human    21 ASCGPQRGPAGSVPASAPARTPPCRLLLVLLLLPPLAASSRPRAWGAAAPSAPHWNETAEKNLGV 85

  Fly   208 IAESTTTSQQLPEYTESSSSSTT---------TFPPTTEYFEDEKERNAEDELDFHSIIYKESHV 263
            :|:...|.||      :|||:.:         |.|....|:     .|.:.|..:|.:..|..|.
Human    86 LADEDNTLQQ------NSSSNISYSNAMQKEITLPSRLIYY-----INQDSESPYHVLDTKARHQ 139

  Fly   264 EDAYENVREGHVAGCGITDEV--SQW-MENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQ 325
            :...:.|   |:|......|.  |:: ::.|.|:.:      :|.||.::|    ::...||   
Human   140 QKHNKAV---HLAQASFQIEAFGSKFILDLILNNGL------LSSDYVEIH----YENGKPQ--- 188

  Fly   326 QPHPPKKYISGDEDFKYPHQ----KYTKEA----NFAEGAFYDPSTGRRLGSSANVADWHQLVHE 382
                   |..|.|...|...    |.:|.|    |...|.|.|       .:...:.:..:||| 
Human   189 -------YSKGGEHCYYHGSIRGVKDSKVALSTCNGLHGMFED-------DTFVYMIEPLELVH- 238

  Fly   383 RVRRATDNGAGDRGSSGG--------SGRGREDNKNTCSLYIQTDPLI----WRHIREGIADHDR 435
                       |..|:|.        :|:..:..||.........|.:    |...|:...:..|
Human   239 -----------DEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSR 292

  Fly   436 G----RKY-EV----DEKTREEITSLIAHH-------VTAVNYIYR---NTK-----FDGRTEHR 476
            |    .|| |:    |.||.::..|..||.       |..|:.||:   ||:     .:..||..
Human   293 GIFEEMKYLELMIVNDHKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRVVLVAVETWTEKD 357

  Fly   477 NIRFEV-------------QRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCL 528
            .|....             ||||                    :|.|..:.::            
Human   358 QIDITTNPVQMLHEFSKYRQRIK--------------------QHADAVHLIS------------ 390

  Fly   529 AYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN-YNSR 592
            ...|.|:            .|:....||:|.:    |..||                 || |.  
Human   391 RVTFHYK------------RSSLSYFGGVCSR----TRGVG-----------------VNEYG-- 420

  Fly   593 VPPKVSQLTLAHEIGHNFG---SPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNI 654
            :|..|:|: |:..:..|.|   .|.....:|......|..||..:..|..|    |||.|||...
Human   421 LPMAVAQV-LSQSLAQNLGIQWEPSSRKPKCDCTESWGGCIMEETGVSHSR----KFSKCSILEY 480

  Fly   655 SNVLD----VLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSL 715
            .:.|.    ..:.|.....|:.:|   |||..||:||||||||: .||...||            
Human   481 RDFLQRGGGACLFNRPTKLFEPTE---CGNGYVEAGEECDCGFH-VECYGLCC------------ 529

  Fly   716 NSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHR 779
                |.|:......|  |.||||.:.||.|.|..|  :|::. .||..:..|.|.:.:||...|:
Human   530 ----KKCSLSNGAHC--SDGPCCNNTSCLFQPRGY--ECRDAVNECDITEYCTGDSGQCPPNLHK 586

  Fly   780 DDKTMCNNGTALCIRGECS--GSPC-LLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRS 841
            .|...||.....|..|||.  .:.| .:|.              :|....|..|.:       :.
Human   587 QDGYACNQNQGRCYNGECKTRDNQCQYIWG--------------TKAAGSDKFCYE-------KL 630

  Fly   842 TSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWI 906
            .:|..:|.|..|.|                |.:::|...|.....|...||....:..|...|.|
Human   631 NTEGTEKGNCGKDG----------------DRWIQCSKHDVFCGFLLCTNLTRAPRIGQLQGEII 679

  Fly   907 VDNWYLVVLMGVAFIVVMGSFIKCCAVH 934
            ..::|           ..|..|.|...|
Human   680 PTSFY-----------HQGRVIDCSGAH 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 65/315 (21%)
Reprolysin_2 450..659 CDD:290307 49/240 (20%)
Disintegrin 684..776 CDD:278623 33/92 (36%)
ADAM23NP_003803.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37 3/15 (20%)
Pep_M12B_propep 127..249 CDD:396235 33/163 (20%)
Reprolysin 299..496 CDD:396140 57/268 (21%)
DISIN 511..585 CDD:214490 33/94 (35%)
May bind the integrin receptor 563..568 1/4 (25%)
ACR 587..726 CDD:214743 31/158 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146048
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.850

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