DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM19

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_150377.1	Gene:	ADAM19 / 8728	HGNCID:	197	Length:	918	Species:	Homo sapiens

Alignment Length:	1071	Identity:	233/1071 - (21%)
Similarity:	353/1071 - (32%)	Gaps:	387/1071 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 SQQL--PEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAG 277
            ::||  |.|||:..:|:.. |.||       .|..||...:|..: :|:.:.....:...|....
Human    83 NEQLFAPSYTETHYTSSGN-PQTT-------TRKLEDHCFYHGTV-RETELSSVTLSTCRGIRGL 138

  Fly   278 CGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKY 342
            ..::..:|..:|          |.|.||....::|.: |.|..|              |:..|:
Human   139 ITVSSNLSYVIE----------PLPDSKGQHLIYRSE-HLKPPP--------------GNCGFE- 177

  Fly   343 PHQKYTKEANFAEGAFYDPSTGRRLGSSANVADW----HQLVHERVRRATDNGAGDRGSSGGSGR 403
             |.|              |:|          .||    .|...:|.||..
Human   178 -HSK--------------PTT----------RDWALQFTQQTKKRPRRMK--------------- 202

  Fly   404 GRED--NKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRN 466
             |||  :.....||:..|.|.::..|.   |.| ..|:::.|         ||::   |:..||:
Human   203 -REDLNSMKYVELYLVADYLEFQKNRR---DQD-ATKHKLIE---------IANY---VDKFYRS 250

  Fly   467 TKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFC----NEHMDVSNFLN----LHSLEDH 523
            .         |||..:..:::           ..|...|    |.:..:.:||:    |.:.:.|
Human   251 L---------NIRIALVGLEV-----------WTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYH 295

  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN 588
            .:   |.:.|...|.|.|:|||.:.:       :|..|::     ||                ||
Human   296 DN---AQLITGMSFHGTTIGLAPLMA-------MCSVYQS-----GG----------------VN 329

  Fly   589 YNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRN 653
            .:..........|:|||:|||||..||....|.....:|..|| |:||.  .|....|:.|:.|.
Human   330 MDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIM-AAATG--HPFPKVFNGCNRRE 391

  Fly   654 ISNVLDVLVG---NTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSL 715
            :...|....|   :...|......|..|||..:|.||||||| .||||.:.||
Human   392 LDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCG-EEEECNNPCC------------ 443

  Fly   716 NSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGTTAECPEPRHR 779
              :|..||.|...:|  :.|.||  :.|..:...  ..|:|:. :|.....|.|.:..||...::
Human   444 --NASNCTLRPGAEC--AHGSCC--HQCKLLAPG--TLCREQARQCDLPEFCTGKSPHCPTNFYQ 500

  Fly   780 DDKTMCNNGTALCIRGEC--SGSPC-LLWN------MTKCF----LTSTTLPHVSK-----RKLC 826
            .|.|.|..|.|.|..|.|  ....| .||.      ...||    :...|..:..|     .:.|
Human   501 MDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKC 565

  Fly   827 D--------LACQDGN-----------DTS--------TCRSTSEFADKYNIQKGGISLQP---- 860
            :        :.||...           ||:        .||.|..:...   ::.|..|.|
Human   566 NMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGP---EEEGDMLDPGLVM 627

  Fly   861 -GSPCDNFQGYCDVFL--KCR-----AVDADGPLLRLKNLLLNRKTLQTVAEWI----------- 906
             |:.|    ||..:..  :||     ..:..|.......:..|.:....:..|.
Human   628 TGTKC----GYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGG 688

  Fly   907 -VDNWYLV----------VLMGVAFIVVMGSFIKCCAVHT------PSSNPKKRRAR-----RIS 949
             :|:..:.          ||:.:..:.|:.....||..:.      ||:.|.|.|.:     |:|
Human   689 SIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVS 753

  Fly   950 ET-----------LRAP------MNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGG 997
            :.           |:.|      :|| ..:.|.|:|        |||
Human   754 QNSGTGHANPTFKLQTPQGKRKVINT-PEILRKPSQ--------PPP------------------ 791

  Fly   998 GGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNS--AANQARRSDG--RGPRSTSS 1058
                          :.|.|:.|  ||....|||...|.::|||  ..:|..|::.  |.|.|
Human   792 --------------RPPPDYLR--GGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPS--- 837

  Fly  1059 GRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLP----LPPPNG 1119
             ||...|.....:...:|..   ..::|:|.:                    |:|    ||.|.|
Human   838 -RPIPPAPNCIVSQDFSRPR---PPQKALPAN--------------------PVPGRRSLPRPGG 878

  Fly  1120 QQQMQQQQQLQLQQPAISPQQQPQQAFYTPK 1150
            ..        .|:.|...|||....|...||
Human   879 AS--------PLRPPGAGPQQSRPLAALAPK 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/277 (23%)
		Reprolysin_2	450..659	CDD:290307	51/216 (24%)
		Disintegrin	684..776	CDD:278623	30/92 (33%)
ADAM19	NP_150377.1	Pep_M12B_propep	58..161	CDD:279848	22/96 (23%)
		Cysteine switch. /evidence=ECO:0000250	130..137		1/6 (17%)
		Reprolysin	210..408	CDD:279729	62/267 (23%)
		ZnMc_adamalysin_II_like	210..406	CDD:239797	62/265 (23%)
		DISIN	439..499	CDD:214490	18/79 (23%)
		ACR	501..646	CDD:214743	32/151 (21%)
		SH3-binding. /evidence=ECO:0000255	833..844		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920