DRSC/TRiP Functional Genomics Resources

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Protein Alignment kuz and ADAMTS10

DIOPT Version :9

Sequence 1:NP_477187.1 Gene:kuz / 34772 FlyBaseID:FBgn0259984 Length:1238 Species:Drosophila melanogaster
Sequence 2:NP_112219.3 Gene:ADAMTS10 / 81794 HGNCID:13201 Length:1103 Species:Homo sapiens


Alignment Length:769 Identity:151/769 - (19%)
Similarity:233/769 - (30%) Gaps:338/769 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 GHVAG-----------CG------ITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLH---K 317
            ||:.|           ||      :.||            .|.|.||            ||   |
Human   126 GHLQGQASSSHVAISTCGGLHGLIVADE------------EEYLIEP------------LHGGPK 166

  Fly   318 KSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVAD------- 375
            .|...::..||...|..|    .::||                      |.::..|.|       
Human   167 GSRSPEESGPHVVYKRSS----LRHPH----------------------LDTACGVRDEKPWKGR 205

  Fly   376 --WHQLVHERVRRATDNGAGDRGSSG---GSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDR 435
              |.:.:.....|...|.. :||..|   ...|.|         |::|  |:       :||   
Human   206 PWWLRTLKPPPARPLGNET-ERGQPGLKRSVSRER---------YVET--LV-------VAD--- 248

  Fly   436 GRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKI--DDDSACRNSYN 498
              |..|....|.::...:...:..|..:::::.. |.|    :...|.|:.:  :|......:::
Human   249 --KMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSL-GST----VNILVTRLILLTEDQPTLEITHH 306

  Fly   499 GPH--NAFCN------EHMDVSNFLNLHSLEDHS--------DFCLAYVFTYRDFTGGTLGLAWV 547
            ...  ::||.      .|....|.:..:.:.:|.        |.|:     |::...||||||.|
Human   307 AGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICI-----YKNKPCGTLGLAPV 366

  Fly   548 ASASGASGGICEKYK--TYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNF 610
                   ||:||:.:  :..|.:|                          ..:..|:||||||.|
Human   367 -------GGMCERERSCSVNEDIG--------------------------LATAFTIAHEIGHTF 398

  Fly   611 GSPHD-YPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASE 674
            |..|| ....|...|.:...:|.|..|.  :.|...:|.||...|::.||..:|           
Human   399 GMNHDGVGNSCGARGQDPAKLMAAHITM--KTNPFVWSSCSRDYITSFLDSGLG----------- 450

  Fly   675 GAFCGNK----------IVESGEECDCGFNEEECK-------DKCCYPRLISEYDQSLNSSAKGC 722
              .|.|.          .|..|:..|.   :|:|:       .:|.|..:.||. ..|:.|    
Human   451 --LCLNNRPPRQDFVYPTVAPGQAYDA---DEQCRFQHGVKSRQCKYGEVCSEL-WCLSKS---- 505

  Fly   723 TRRAKTQCSP-SQGPCCLSNS-----CTFVPTSYHQKC------KEETECSW---------SSTC 766
             .|..|...| ::|..|.:::     |      |.:.|      .|..:.:|         |.||
Human   506 -NRCITNSIPAAEGTLCQTHTIDKGWC------YKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTC 563

  Fly   767 NG----TTAECPEP--------------RHR----DD---------KTMCNNGTALCIRGE---- 796
            .|    ::..|..|              |||    ||         :..|:...::..||:    
Human   564 GGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKW 628

  Fly   797 ----------CS--------------------GSPCLLWNMTKCFLTSTTLPHV----------- 820
                      ||                    |:||....:..|  .|....||           
Human   629 KTYRGGGVKACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDIC--VSGECKHVGCDRVLGSDLR 691

  Fly   821 -SKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDV 873
             .|.::|      |.|.|.|.:..           |: ..|.||   ..||.||
Human   692 EDKCRVC------GGDGSACETIE-----------GV-FSPASP---GAGYEDV 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kuzNP_477187.1 ZnMc_TACE_like 410..677 CDD:239798 59/287 (21%)
Reprolysin_2 450..659 CDD:290307 48/229 (21%)
Disintegrin 684..776 CDD:278623 25/123 (20%)
ADAMTS10NP_112219.3 Pep_M12B_propep 73..179 CDD:279848 17/76 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..233 5/20 (25%)
Reprolysin 239..457 CDD:279729 62/298 (21%)
ZnMc_ADAMTS_like 239..454 CDD:239801 61/295 (21%)
TSP1 550..602 CDD:214559 12/51 (24%)
Spacer 706..828 8/34 (24%)
ADAM_spacer1 706..818 CDD:283607 8/34 (24%)
TSP1 829..885 CDD:214559
TSP1 952..1003 CDD:214559
TSP1 1010..1054 CDD:214559
PLAC 1069..1100 CDD:285849
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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