DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM33

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_005260900.1	Gene:	ADAM33 / 80332	HGNCID:	15478	Length:	826	Species:	Homo sapiens

Alignment Length:	1050	Identity:	209/1050 - (19%)
Similarity:	296/1050 - (28%)	Gaps:	437/1050 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 VREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSK-----------------DYQKLHR----K 313
            |.:||:.|..:|   ..|:.:.|......|.||:||                 :.:|.||    .
Human    30 VLQGHIPGQPVT---PHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPG 91

  Fly   314 QLHKKSAPQQQQQPHPPKKYI--------SGDEDFKYPHQKYTKEA------------------- 351
            .:.....|..|.....|...:        :..||    |..|....
Human    92 YIETHYGPDGQPVVLAPNHTVRCFHGLWDAPPED----HCHYQGRVRGFPDSWVVLCTCSGMSGL 152

  Fly   352 -NFAEGAFYD----PSTGRRLGSSANVADWHQLV-------HERVRRATDNGAGDRGSSGG-SGR 403
             ..:..|.|.    |..|.:..|:..:....||:       |    |...|.||.....|| ..|
Human   153 ITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGH----RDPGNKAGMTSLPGGPQSR 213

  Fly   404 GREDNKNT---CSLYIQTDPLIW--RHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYI 463
            ||.:.:.|   ..|||..|..::  ||..   .:|.:.|..||               ...|:.:
Human   214 GRREARRTRKYLELYIVADHTLFLTRHRN---LNHTKQRLLEV---------------ANYVDQL 260

  Fly   464 YRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCL 528
            .|............:..|..|.::..|:      |....||.....      .|.:...|..
Human   261 LRTLDIQVALTGLEVWTERDRSRVTQDA------NATLWAFLQWRR------GLWAQRPHDS--- 310

  Fly   529 AYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRV 593
            |.:.|.|.|.|.|:|||.|.       |:|.     .|:.||                |:.:...
Human   311 AQLLTGRAFQGATVGLAPVE-------GMCR-----AESSGG----------------VSTDHSE 347

  Fly   594 PPKVSQLTLAHEIGHNFGSPHDYPQEC--RPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISN 656
            .|..:..|:||||||:.|..|| |..|  .....:|..:| |:||.  .|....||.||.|.:
Human   348 LPIGAAATMAHEIGHSLGLSHD-PDGCCVEAAAESGGCVM-AAATG--HPFPRVFSACSRRQL-- 406

  Fly   657 VLDVLVGNTKRDCFKASEG---------------AFCGNKIVESGEECDCGFNEEECKDKCCYPR 706
                      |..|:...|               |.|||..||:||||||| ..:||:|.||:
Human   407 ----------RAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCG-PGQECRDLCCF-- 458

  Fly   707 LISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECSWSSTCNGTT 770
                        |..|:.|...||  :.|.||:  .|...|..  ..|::.. :|.....|.||:
Human   459 ------------AHNCSLRPGAQC--AHGDCCV--RCLLKPAG--ALCRQAMGDCDLPEFCTGTS 505

  Fly   771 AECPEPRHRDDKTMCNNGTALCIRGECSGSPCL------LWN------MTKCFLTSTT------- 816
            :.||...:..|.:.|..|:..|..|.|   |.|      ||.      ...||....:
Human   506 SHCPPDVYLLDGSPCARGSGYCWDGAC---PTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGN 567

  Fly   817 ---------LPHVSKRKLC-DLACQ--------------------DGNDTSTCRSTSEFADKYNI 851
                     ||...:..|| .|.||                    ||.:. |||........ .:
Human   568 CGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEV-TCRGALALPSA-QL 630

  Fly   852 QKGGISL-QPGSPC-------------DNFQ------------GYCDVFLKCRAVDA-------- 882
            ...|:.| :||:.|             :.||            |.|:....|.....
Human   631 DLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDK 695

  Fly   883 --------DGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSN 939
                    .||:....:                |.:.|.:|:.|...::.|:.:..|....|.::
Human   696 PGFGGSMDSGPVQAENH----------------DTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAH 744

  Fly   940 PKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHG 1004
                 .:|.|...|          |.|  ..:||:..|
Human   745 -----LQRCSWGCR----------RDP--ACSGPKDGP--------------------------- 765

  Fly  1005 GSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGRPQAIASGSG 1069
                 |:.|                |.||.|...            .||.:|..
Human   766 -----HRDH----------------PLGGVHPME------------LGPTATGQ----------- 786

  Fly  1070 AASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQP 1134
                                                     |.||.|.|..:.....::   ..|
Human   787 -----------------------------------------PWPLDPENSHEPSSHPEK---PLP 807

  Fly  1135 AISPQQQPQQ 1144
            |:||..|..|
Human   808 AVSPDPQADQ 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/288 (22%)
		Reprolysin_2	450..659	CDD:290307	50/210 (24%)
		Disintegrin	684..776	CDD:278623	30/92 (33%)
ADAM33	XP_005260900.1	Pep_M12B_propep	<83..177	CDD:279848	15/97 (15%)
		Reprolysin	223..422	CDD:279729	63/275 (23%)
		ZnMc_adamalysin_II_like	223..420	CDD:239797	63/273 (23%)
		DISIN	439..513	CDD:214490	30/94 (32%)
		ACR	515..657	CDD:214743	29/146 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920