DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam23a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_001923262.2	Gene:	adam23a / 794175	ZFINID:	ZDB-GENE-070810-2	Length:	785	Species:	Danio rerio

Alignment Length:	816	Identity:	175/816 - (21%)
Similarity:	262/816 - (32%)	Gaps:	294/816 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PSTSTTSSATTATKSTQPTRPLAKSNT--STTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSS 228
            ||:..|||..:::...:..|....|.|  ..||.:..||.   |..|...
Zfish    18 PSSIATSSTVSSSVQNEALRDQHVSETPREATAPDDSTEG---KTGEHPV--------------- 64

  Fly   229 TTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVA-------GCGITDEVSQ 286
            |.|:|....|:     .|.|.|..||.:   ::..::...:.::.|:|       ..|.|..:..
Zfish    65 TITYPSRLIYY-----LNEESESTFHDL---DTRAKNQAGDGQDVHLAQASFQLDAFGTTFTLDL 121

  Fly   287 WMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEA 351
            .:.|          :.:|.||.::|    ::...|...:         .|:..:.:.|.:..:::
Zfish   122 TLNN----------DLLSSDYIEIH----YENDKPVLSR---------GGEHCYYHGHVRGKEDS 163

  Fly   352 -------NFAEGAFYD---------------------PSTGRR---LGSSANVADWHQLVHERVR 385
                   |...|.|.|                     |.|.||   ||.::...||
Zfish   164 RAALSTCNGLHGMFDDGNFVYLIEPQKQTHTAETEARPHTLRRTSSLGLTSIPDDW--------- 219

  Fly   386 RATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREG----------------IADHD 434
            .|.|..              |:.:...|:     |.:.|..:..                :|||:
Zfish   220 TADDPD--------------EEKRIFASM-----PWLKRRRKRAMPRNIFEEMKYLEIMIVADHN 265

  Fly   435 RGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKI--DDDSACRNSY 497
            ..:|:...:.||....||    |..|:.|::        |..|.|..:..::|  |.|..
Zfish   266 TFKKHRSKKHTRNTAKSL----VNLVDAIFK--------EQLNTRVVLVAVEIWTDKDRI----- 313

  Fly   498 NGPHNAFCNEHMDVSNFLNLHSLEDHSDFC------------LAYVFTYRDFTGGTLGLAWVASA 550
              |              |::..||...||.            ..::||...|..|       .|:
Zfish   314 --P--------------LSVKPLEMLKDFSKYRQQNININADAVHLFTNMTFHYG-------RSS 355

  Fly   551 SGASGGICEKYKTY-------TETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGH 608
            .|..||:|.|.:..       |.|:.|.:..                          :||..:|.
Zfish   356 VGYIGGVCSKARGIGVNEFGNTWTMAGFFSQ--------------------------SLAQNLGI 394

  Fly   609 NFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVG------NTKR 667
            .: .|....:||  |.::.........|....|.  |||.|||.:..|.|  |.|      |...
Zfish   395 QW-DPSLRRKEC--GCMDSWLGCIMEDTGVQHPR--KFSKCSITDYRNFL--LRGGASCLFNKPN 452

  Fly   668 DCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSP 732
            ..|:|:|   |||..||.||||||| ...||...||                |.|:......|
Zfish   453 KLFEATE---CGNGYVEVGEECDCG-ARMECYKDCC----------------KKCSLSNGAHC-- 495

  Fly   733 SQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGE 796
            |.|||| :.:|.|.|..|  .|: ...:|..|.||:|.:.:||...|:.|...|......|..||
Zfish   496 SDGPCC-NGTCLFYPRGY--SCRFAVNDCDISETCSGDSGQCPPNLHKQDGYSCQLNQGRCYSGE 557

  Fly   797 CS--GSPC-LLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTC--RSTSEFADKYNIQKGGI 856
            |.  .|.| .:|..                       :.|.....|  :..:|..:|.|..:.|.
Zfish   558 CKTRESQCKYIWGP-----------------------KAGGSEKHCYEKLNTEGTEKGNCGRDGD 599

  Fly   857 SLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNL 892
            ...|.|..|.|.||    |.|   .:.|.:.|:..|
Zfish   600 KWVPCSKHDVFCGY----LLC---SSTGRIPRIGTL 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/309 (20%)
		Reprolysin_2	450..659	CDD:290307	46/229 (20%)
		Disintegrin	684..776	CDD:278623	32/92 (35%)
adam23a	XP_001923262.2	Pep_M12B_propep	97..202	CDD:279848	16/127 (13%)
		Reprolysin	254..451	CDD:279729	56/269 (21%)
		ZnMc_adamalysin_II_like	254..449	CDD:239797	55/267 (21%)
		Disintegrin	466..538	CDD:278623	32/93 (34%)
		ACR	541..682	CDD:214743	26/118 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579581
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850