DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam30

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001103070.1	Gene:	Adam30 / 690547	RGDID:	1594713	Length:	726	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	144/717 - (20%)
Similarity:	225/717 - (31%)	Gaps:	287/717 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 EDNKNTC-----------SLYIQTDPL----IWRHIREGIADHDRGRK------YEVDEKTREEI 449
            |...:||           |.|.|.:||    .:.|:...:.:.:.|.:      .|.|.:|.||
  Rat   121 ESTLSTCMGGLRGVLNIDSRYYQIEPLRASSRFEHVVYLLTEDNFGNETCGVVDEETDGQTAEE- 184

  Fly   450 TSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQR--------IKIDDDSACRNSYNGPHNAFCN 506
                 ..|..:...:::.|.....|...: |::.|        .::.:|:....|....:
  Rat   185 -----EEVARIKNFHQSYKHQRYLELVMV-FDLSRYVFTRGNMTRMVEDAILLASIADTY----- 238

  Fly   507 EHMDVSNFLNLHSLEDHSDF-------------------------------CLAYVFTYRDFTGG 540
             ..|||..:.|.:||..:.|                               ..|:::..|.::..
  Rat   239 -FQDVSLKIQLKALEVWTQFDKIHLYYSSLSQVLGQFVLYKRASLHHRLPADWAHLYIARRYSDA 302

  Fly   541 TLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHE 605
            |   ||      :.|..||::...:.:                 :|:|.|...|...:    |||
  Rat   303 T---AW------SWGRACEEFHAGSAS-----------------SFLNVNLLGPATWT----AHE 337

  Fly   606 IGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF 670
            :||..|..|| .:.|:..| ..:.:|....|.        ||.||...........:.....|..
  Rat   338 MGHCVGMYHD-EEFCQCRG-RKSCVMGTGRTG--------FSNCSYHQYFLHASYKMSYCLSDFP 392

  Fly   671 KASEGAFCGNKIVESGEECDCGFNEEECK-DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQ 734
            |......|||||||:.|||||| :||||| |.||.|               .|..:....|  |.
  Rat   393 KLHIVERCGNKIVENKEECDCG-SEEECKSDLCCGP---------------DCKWKEGVNC--SS 439

  Fly   735 GPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNG---------- 788
            |.||  :.|.|:|:.|  .|: ||.||..:..|:|.:..||:..::.|.|.|..|
  Rat   440 GLCC--HKCNFLPSGY--VCREEENECDLAEYCDGLSGFCPKDYYKQDGTPCRYGGFCFHKGCRS 500

  Fly   789 ---------------------TALCIRGECSGSPCLLWNMT------------------------ 808
                                 .|:.:.|:.||: |.:.|.|
  Rat   501 RYLQCQAIFGRRAKEAPRQCYDAVNMIGDQSGN-CGIVNATRYTKCHRDNTICGRLQCVNIKALS 564

  Fly   809 ------------------KCFLTS---TTLPH-------------VSKRKLC-DLACQD------ 832
                              ||:.||   |.:||             ....::| :..|.|
  Rat   565 RFPDHTLLLSTHLKKDNLKCWGTSYHGTMIPHGVPDIGDVNDGTSCGPNRVCLNRTCVDYATLKF 629

  Fly   833 ------------GNDTSTCRSTSEFADKYNIQKG-GISLQPGSPCDNFQGYCDVFLKCRAVDADG 884
                        .|:...|..|..:...:.::.| |.|:..|.|                    |
  Rat   630 DCLPKKCNSRGVCNNKKNCHCTYGWEPPFCVEVGYGGSIDSGPP--------------------G 674

  Fly   885 PLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRIS 949
            |..||..:.:                 |.:|..:.||.   |.|..|......:..:||:.:..:
  Rat   675 PRARLAKVHV-----------------LYMLRTILFIF---SVIVVCFTQRMKNLFRKRQQKNPA 719

  Fly   950 ET 951
            ||
  Rat   720 ET 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	58/326 (18%)
		Reprolysin_2	450..659	CDD:290307	42/247 (17%)
		Disintegrin	684..776	CDD:278623	35/93 (38%)
Adam30	NP_001103070.1	Pep_M12B_propep	48..157	CDD:279848	9/35 (26%)
		Reprolysin	201..392	CDD:279729	41/237 (17%)
		ZnMc_adamalysin_II_like	201..390	CDD:239797	40/235 (17%)
		Disintegrin	406..478	CDD:278623	35/93 (38%)
		ACR	482..623	CDD:214743	20/141 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850