DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam34

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001128562.1	Gene:	Adam34 / 685846	RGDID:	1589040	Length:	712	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	130/573 - (22%)
Similarity:	208/573 - (36%)	Gaps:	177/573 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 KNTCSL--YIQTDPLIWRHIR------EGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYR 465
            :|.|..  |:..||.....|.      :||.:.: |..||:..|:.......:|:.|..    .:
  Rat   107 QNDCYYLGYVDEDPESLVIINTCFGSLQGILEIN-GTTYEIMPKSSSSTFEHLAYKVDT----DK 166

  Fly   466 NTKFDGR--TEHRNIRFEVQRIKIDDDSACRNSYNG--------------PHNAFCNEH------ 508
            :..|..|  ...:.|..:::..:.:|....:|.|..              .||.:.:.:
  Rat   167 SESFTMRCGLSEKEIARQMKLQENNDSILLQNPYENWWTHHRFIDYFVVLDHNRYVHRNNNTTTC 231

  Fly   509 ----MDVSNFLNLHSLEDHSDFCLA--YVFTYRDFTGGTLGLAWVASASGASGGICEKYKTY-TE 566
                :.:.|.:|.:.|:..:|..|.  .|::.|:.......:..|.:|          :.|: ..
  Rat   232 IQDMLQIVNGINGYYLQIDTDVVLTTLQVWSERNLVNVEQDIQMVLTA----------FCTWKIN 286

  Fly   567 TVGGQYQS------TKRS-------LNTGIITFV---NYNSRVPPKVSQLT--LAHEIGHNFGSP 613
            |:|.:.:.      .||.       .|.|.:...   ..||.:...:|.:.  :|||:|||.|..
  Rat   287 TIGNRIRHDIIHLYVKRGYGIYLGLANVGTVCITLNCAVNSFISDSLSDMAFIIAHEMGHNLGMM 351

  Fly   614 HDYP------QECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKA 672
            ||..      |.|         ||     :..:.|:.|||.||...:.:|::      ||.|...
  Rat   352 HDVSGCTCGRQSC---------IM-----APYKSNSPKFSNCSYEEMYSVVN------KRSCLYD 396

  Fly   673 SEGAF--------CGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKT 728
            ...|.        ||||:||..|:|||| |.|.| ||.||               ::.|..:...
  Rat   397 IPDALKTNLTLTVCGNKMVEEEEQCDCG-NLESCLKDPCC---------------SEDCVLKPGA 445

  Fly   729 QCSPSQGPCCLSNSCTFVPTSYHQKC-KEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALC 792
            ||  :.|.||  ..|.|:||.  ..| ||:.||.....|||::.|||...:::|...| :|...|
  Rat   446 QC--AFGLCC--KDCQFLPTG--TVCRKEKNECDLPEWCNGSSHECPGDVYKEDGNPC-SGDGYC 503

  Fly   793 IRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQD--GNDTSTCRSTSEFADKYNIQKGG 855
            .:..|.                   .|       |..|::  ||.:   ||..|.......::|
  Rat   504 YKMACH-------------------QH-------DEQCRNIFGNGS---RSAGEICYTEMNKRG- 538

  Fly   856 ISLQPGSPCDNFQGYC----DVFLKCRAVDADGPLLRLKNL--LLNRKTLQTV 902
                     |.| |.|    ..:.:|:..|.....::.:|:  |..||..:||
  Rat   539 ---------DRF-GNCGNDSSKYRRCQPADVFCGRIQCENVTELPQRKNHETV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	64/327 (20%)
		Reprolysin_2	450..659	CDD:290307	49/261 (19%)
		Disintegrin	684..776	CDD:278623	34/93 (37%)
Adam34	NP_001128562.1	Pep_M12B_propep	44..160	CDD:396235	12/53 (23%)
		ZnMc_adamalysin_II_like	208..396	CDD:239797	44/217 (20%)
		Disintegrin	416..488	CDD:395147	34/93 (37%)
		ACR	493..628	CDD:214743	26/130 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920