DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam12

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017445729.1	Gene:	Adam12 / 679837	RGDID:	1583652	Length:	903	Species:	Rattus norvegicus

Alignment Length:	926	Identity:	205/926 - (22%)
Similarity:	292/926 - (31%)	Gaps:	353/926 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 NVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLY-IQTDP-LIW--RHIREG--- 429
            |..|.::||      ..:|....:|..|.     ..||::.::. :..:| .:|  ||.||.
  Rat   157 NTTDRYKLV------PAENMKNIQGLCGS-----HHNKSSLTMEDVFPEPSQMWGRRHKRETLKM 210

  Fly   430 --------IADHDRGRKYEVD-EKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRI 485
                    :||:...::...| ||.::.:.. ||:|   |:..||..         |||..:..:
  Rat   211 TKYVELVIVADNREFQRQGKDLEKVKQRLIE-IANH---VDKFYRPL---------NIRIVLVGV 262

  Fly   486 KI-DDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSL-----EDHSDFCLAYVFTYRDFTGGTLGL 544
            :: :|...|..|    .:.|.:.|    .||:...|     :.|.:   |.:.:...|.|.|:|:
  Rat   263 EVWNDIDKCSIS----QDPFTSLH----EFLDWRKLKLLPRKSHDN---AQLISGVYFQGTTIGM 316

  Fly   545 AWVASASGA--SGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIG 607
            |.:.|...|  |||:...:..                              .|..:.:|||||:|
  Rat   317 APIMSMCTAEQSGGVVMDHSD------------------------------SPLGAAVTLAHELG 351

  Fly   608 HNFGSPHDYPQ---ECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDC 669
            ||||..||..:   .||.....|..||..|.   ..|....||.||.:::...|:..:|.    |
  Rat   352 HNFGMNHDTLERGCSCRMAAEKGGCIMNPST---GFPFPMVFSSCSRKDLEASLEKGMGM----C 409

  Fly   670 F-------KASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAK 727
            .       :|..|..|||..||.||||||| ..|||.::||              :|..||.:..
  Rat   410 LFNLPEVKQAFGGRKCGNGYVEDGEECDCG-EPEECTNRCC--------------NATTCTLKPD 459

  Fly   728 TQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTAL 791
            ..|  :.|.||  ..|...|..  ..|: ....|.....|.||...||...:..|...|......
  Rat   460 AVC--AHGQCC--EDCQLKPPG--TACRGSSNSCDLPEFCTGTAPHCPANVYLHDGHPCQGVDGY 518

  Fly   792 CIRGECS--GSPCL-LWNMTK------CF--LTSTTLPHVSKRK-------LCDL--------AC 830
            |..|.|.  ...|: ||....      ||  :.|...|:.:..|       .|:|        .|
  Rat   519 CYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKDSKSSFVKCELRDAKCGKIQC 583

  Fly   831 QDG--------NDTS-------------TCRSTSEFADKYNIQKG----GISLQPGSPCDNFQGY 870
            |.|        |..|             .||.|..:........|    |.....|..|.|.|
  Rat   584 QGGASRPVIGTNAVSIETNIPQQEGGRILCRGTHVYLGDDMPDPGLVLAGTKCAEGKICLNRQ-- 646

  Fly   871 C---DVF--LKCRAVDADGPLLRLKNLLLNRKTLQTVAEWI--------------------VDNW 910
            |   .||  .|| |:...|     :.:..|||.....|.|.                    .||.
  Rat   647 CQNISVFGVHKC-AMQCHG-----RGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQ 705

  Fly   911 YLVV--------LMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQ-RHP 966
            .|.|        |:...|:|.:                |::...|:..|.:  .||:.::: .|.
  Rat   706 GLTVGILVSVLCLLAAGFVVYL----------------KRKTLMRLLFTHK--KNTMEKLRCVHT 752

  Fly   967 NQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPL-- 1029
            ::..:|||  |..||...       |:|                                 ||
  Rat   753 SRTPSGPR--PGQAHHIL-------GKG---------------------------------PLMS 775

  Fly  1030 ------PTGGSHSSRNSAANQARRSDGR---GPRSTSSGRPQAIA----SGSGAASGAARSHGGY 1081
                  .|...||.:....:.:|..:.|   .|:|     ||.:.    ....|.||.||
  Rat   776 RPPHFNTTKDRHSLKCQNIDISRPLNARVVPQPQS-----PQRVLLPLHQAPRAPSGPAR----- 830

  Fly  1082 GAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAF 1146
                                         |||..|...|.|...:.         ||.|:|
  Rat   831 -----------------------------PLPANPAVRQAQGTHKP---------SPPQKP---- 853

  Fly  1147 YTPKELPPRNKSRSSR 1162
                 ||....||:||
  Rat   854 -----LPADPLSRTSR 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	69/300 (23%)
		Reprolysin_2	450..659	CDD:290307	53/219 (24%)
		Disintegrin	684..776	CDD:278623	29/92 (32%)
Adam12	XP_017445729.1	Pep_M12B_propep	64..160	CDD:279848	1/2 (50%)
		Reprolysin	212..414	CDD:279729	61/262 (23%)
		ZnMc_adamalysin_II_like	212..412	CDD:239797	61/260 (23%)
		DISIN	431..505	CDD:214490	29/94 (31%)
		ACR	508..650	CDD:214743	30/143 (21%)
		CAC1F_C	<751..>895	CDD:293490	41/213 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920