DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam19

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001035105.1	Gene:	adam19 / 677730	XenbaseID:	XB-GENE-993485	Length:	911	Species:	Xenopus tropicalis

Alignment Length:	936	Identity:	193/936 - (20%)
Similarity:	287/936 - (30%)	Gaps:	353/936 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 HERVRRATDNGAGDRGSSGGSGRGREDNKNTC-SLYIQTDPLIWRHIREGIADHDRGRKYEVD-E 443
            |.||||  :|..|:|                | .||:             :||:...:|::.| |
Frog   197 HSRVRR--ENVEGER----------------CVELYL-------------VADYAEFQKHDSDLE 230

  Fly   444 KTREEITSLIAHHVTAVNYI---YRNTKFDGRTEHRNIRFEVQRIKI----DDDSACRNSYNGPH 501
            :|:.::       :..:|||   ||..         |||..:..:::    |..:...|.|:
Frog   231 ETQRKM-------LEVMNYIDKFYRAL---------NIRIALVGLEVWTAGDKCNVSENPYS--- 276

  Fly   502 NAFCNEHMDVSNFLN-LHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYT 565
                    .:..||: ...|..|:....|.:.|.|.|.|.|:|||.:.:       :|..|::
Frog   277 --------TLRAFLSWRRKLLQHTPHDNAQLITGRSFYGTTIGLAPLQA-------MCSVYQS-- 324

  Fly   566 ETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYI 630
               ||                ||.:..........|:|||:|||||..||....|......|..|
Frog   325 ---GG----------------VNMDHSDNAIGVAATMAHELGHNFGMSHDAAGCCTAKPEEGGCI 370

  Fly   631 MFASATSGDRPNNSKFSPCSIRN------------ISNVLD--VLVGNTKRDCFKASEGAFCGNK 681
            |   |.|...|....|:.|:.:.            :||:.|  .|.|           |..|||.
Frog   371 M---AASTGHPFPKVFNACNKQELDRFFRSGGGMCLSNLPDTKTLFG-----------GPRCGNG 421

  Fly   682 IVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFV 746
            .:|.||:|||| :.|:|.:.||              :|..||..|...|  :.|.|||  .|...
Frog   422 FLEEGEQCDCG-DPEQCNNPCC--------------NATTCTLMAGADC--AHGACCL--RCKLR 467

  Fly   747 PTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPC-LLWNM 807
            |..:  .|::.:. |.....|.|.:|.||....:.|.|:|....|.|..|.|  ....| .||..
Frog   468 PPGF--PCRKPSRPCDLPEFCTGQSAVCPPNSFQLDGTLCQGEQAFCYNGRCLTHQQQCQQLWGA 530

  Fly   808 TK------CF------------------------------------LTSTTLPHVSKRKLCDLAC 830
            ..      ||                                    |:..:.|..|.....|...
Frog   531 RSRVAPDLCFELINVAGDQYGNCGRDMSGTYRSCEGRDVMCGKIQCLSQASKPMESNAVAIDTTI 595

  Fly   831 QDGNDTSTCRSTSEFADKYNIQKGGISLQPGSPCD----NFQGYC--DVFLKCRAVDADGPLLRL 889
            ........||.|..:.::.::...|:.| .|:.|.    .|.|.|  ..||:   ||........
Frog   596 TIEGKRVQCRGTHIYKEEDDLMDPGLVL-TGTKCGLNQICFDGQCRNTSFLQ---VDECAKKCHG 656

  Fly   890 KNLLLNRKTLQTVAEW------------IVDN-------------WY---LVVLMGVAFIVVMGS 926
            ..:..|.:.....|.|            .:|:             |.   |.:|.|:|..:.|..
Frog   657 NGMCNNNRNCHCFAGWRPPFCNQTGNGGSIDSGPVPEDGSLALVLWICIPLALLAGMALSLAMFF 721

  Fly   927 FI-----------KC---CAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIP 977
            ::           .|   |.:|...|..|........:..:.||........:|..|....:|..
Frog   722 YVFRIRGRQAKTESCPATCPLHKSDSPTKHGVGSTSKQRPQVPMQPKSPPVLYPTLRVEKSQSAA 786

  Fly   978 PPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGG-----HSIVPLPTGGSHSS 1037
            ...|:.|           ..||..::..:.|||....     .:||     |.:..|..||:..:
Frog   787 SQHHQEQ-----------PEGGAAKYSSAISHHSNQD-----LKGGAGKILHGVSYLQQGGAIKT 835

  Fly  1038 RNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSG 1102
                 ..|.|:.   |.:..:..|.|:|...
Frog   836 -----GYAMRTP---PPNRPAPPPPALAPTP---------------------------------- 858

  Fly  1103 GVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELP-----PRNKSRSSR 1162
                    |.|:|||                ||.:|.....:....|:.||     |.|::|..
Frog   859 --------PAPVPPP----------------PASAPPPPAPKRLERPRRLPLPPPVPPNRTRRK- 898

  Fly  1163 TNNTSNTTTTTNSSTAAAGSGSVSGP 1188
                             |...|.|||
Frog   899 -----------------AMDSSFSGP 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	65/290 (22%)
		Reprolysin_2	450..659	CDD:290307	52/228 (23%)
		Disintegrin	684..776	CDD:278623	29/92 (32%)
adam19	NP_001035105.1	Pep_M12B_propep	63..163	CDD:279848
		Reprolysin	211..407	CDD:279729	60/266 (23%)
		ZnMc_adamalysin_II_like	211..405	CDD:239797	58/264 (22%)
		DISIN	424..498	CDD:214490	29/94 (31%)
		ACR	500..642	CDD:214743	26/142 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010