DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam12

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001035103.1	Gene:	adam12 / 677729	XenbaseID:	XB-GENE-982139	Length:	925	Species:	Xenopus tropicalis

Alignment Length:	814	Identity:	177/814 - (21%)
Similarity:	270/814 - (33%)	Gaps:	243/814 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 HPP-KKYISGDEDFK----YPHQKYTKEANFA------EGAFYDPSTGRRLGSSANVADWHQLVH 381
            ||| .|.:...:|.:    ....|.....||:      :|.|        :.::.|..| |...|
Frog    81 HPPAMKVLLKAKDIRLLISLERNKGLFAGNFSTTHYTEDGVF--------VSTALNYTD-HCYYH 136

  Fly   382 ERVRRATDNGAGDRGSSGGSG----RGR------EDNKNTCSLYIQTDPLIWRHIREGIADH--- 433
            .:|...:::.......||..|    ..|      :.|..|..|:.|.:.|  :.|....:.|
Frog   137 GKVEGYSESSVSVSSCSGLRGLITLENRAYVLEPQANSTTSHLFYQAEHL--KLISGSCSQHFNL 199

  Fly   434 -------------DRGRKYEVDEKTREEITSLIAHHVTAVNYIY-RNTKFDGRTEHR-------- 476
                         |..::::.|.....:...|:   :.|.|..| |..|...:.:||
Frog   200 SGVSLSDNFQHSQDTFKRHKRDTVKTTKYVELV---IVADNREYQRQGKDVDKVKHRLIGMANYV 261

  Fly   477 -------NIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTY 534
                   |||..:..::|..||...:....|.... .|.:|... |.|...:.|.:   |.:.:.
Frog   262 DKFFRPLNIRVALVGVEIWSDSDKCSITQDPFTTL-QEFLDWRK-LKLLPQKPHDN---AQLVSG 321

  Fly   535 RDFTGGTLGLAWVASASGA--SGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKV 597
            ..|.|.|:|:|.:.|...|  ||||                            .::::..  |..
Frog   322 VYFQGTTIGMAPIMSMCTADKSGGI----------------------------VMDHSGN--PLG 356

  Fly   598 SQLTLAHEIGHNFGSPHDYPQ---ECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLD 659
            :.:|||||:|||||..||..:   .||....||..||..|..   .|..:.||.|..:::.:.|:
Frog   357 AAVTLAHELGHNFGMNHDTLERGCNCRGSADNGGCIMTPSTA---YPFPTVFSSCGKKDLDSSLE 418

  Fly   660 VLVGNTKRDCFKASEGAF----CGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAK 720
            ..||....:..:.:| :|    |||..||.||:|||| ..:||.:.||              :|.
Frog   419 KGVGMCLYNMPEVTE-SFGEQKCGNGYVEEGEQCDCG-EPDECTNPCC--------------NAS 467

  Fly   721 GCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTM 784
            .|..:....|  :.|.||  ..|...|..  ..|::... |.....|:||:|.||...:..|...
Frog   468 LCMLKPGAVC--AHGLCC--EDCKLKPAG--TPCRDANNFCDLPEFCSGTSAHCPANVYLHDGHP 526

  Fly   785 CNNGTALCIRGECS--GSPCL-LWNMTK------CF--LTSTTLPHVSKRK-------LCD---- 827
            |......|..|.|.  ...|: ||....      ||  :.|...|:.:..|       .|:
Frog   527 CFKIEGYCYNGVCQTHEQQCITLWGQGAKPAPGICFERVNSAGDPYGNCGKDSTGSFTKCENRDA 591

  Fly   828 ----LACQDG--------NDTS-------------TCRST-----SEFADKYNIQKGGISLQPGS 862
                :.||.|        |..|             .||.|     .:..|. .:...|...:.|.
Frog   592 KCGKIQCQGGANRPVIGTNAVSIETNIPLQEGRRILCRGTHVYLGDDLPDP-GLVLAGTKCEEGK 655

  Fly   863 PCDNFQ-------GYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEW--------------- 905
            .|.|.:       |..|..|||..          ..:..|:|.....|||
Frog   656 ICLNRKCQNISIFGVHDCALKCHG----------HGVCNNKKNCHCEAEWAPPFCDKHGFGGSVD 710

  Fly   906 -----IVDNWYL----VVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRR 961
                 :.||..|    :|.:|..|:.....::|...:.....:.||...    |.||:...:...
Frog   711 SGPVRLHDNRSLITGMIVTIGCIFLAAFIVYLKRKTLFQWLFSNKKTTI----EKLRSVRPSRGG 771

  Fly   962 MQRHPNQ--RGAGPRSI------PPPAHEAQHYS 987
            ....|||  |.|..:.:      ||....:..|:
Frog   772 CSNEPNQEYRTALSKHVLSKPACPPKEESSIQYN 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	68/303 (22%)
		Reprolysin_2	450..659	CDD:290307	56/229 (24%)
		Disintegrin	684..776	CDD:278623	27/92 (29%)
adam12	NP_001035103.1	Pep_M12B_propep	77..186	CDD:279848	23/113 (20%)
		Reprolysin	227..429	CDD:279729	59/242 (24%)
		ZnMc_adamalysin_II_like	227..427	CDD:239797	59/240 (25%)
		DISIN	446..520	CDD:214490	27/94 (29%)
		ACR	523..665	CDD:214743	27/142 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920