DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam22

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_038964489.1	Gene:	Adam22 / 57033	RGDID:	1585016	Length:	977	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	156/753 - (20%)
Similarity:	235/753 - (31%)	Gaps:	263/753 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 GLAWVASASGAS--GGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHE 605
            |..:.:|.|||:  ||||...:.     ||..:..|..|                  ..:|||..
  Rat   329 GSQFESSRSGAAYIGGICSLLRG-----GGVNEFGKTDL------------------MAVTLAQS 370

  Fly   606 IGHNFGSPHDYPQ----ECR-----PG---GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVL 658
            :.||.|...|..:    ||:     .|   |..|.|:            ..||:.|:|....:.|
  Rat   371 LAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYL------------PKKFTQCNIEEYHDFL 423

  Fly   659 DVLVGNTKRDCF-----KASEGAFCGNKIVESGEECDCGFNEEECK---DKCCYPRLISEYDQSL 715
            :...|    .|.     |..:...|||..:|:||||||| ...||.   .:||
  Rat   424 NSGGG----ACLFNKPSKLLDPPECGNGFIETGEECDCG-TPAECALEGAECC------------ 471

  Fly   716 NSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHR 779
                |.||....:||  |.|.||  ..|.|.|..  ..|:|. .:|.....|:|.:::|....|:
  Rat   472 ----KKCTLTQDSQC--SDGLCC--KKCKFQPLG--TVCREAVNDCDIREICSGNSSQCAPNVHK 526

  Fly   780 DDKTMCNNGTALCIRGECS--GSPC-LLWNM------------------------------TKC- 810
            .|...|:....:|..|.|.  ...| .:|..                              |:|
  Rat   527 MDGYSCDGTQGICFGGRCKTRDRQCKYIWGQKVTASDRYCYEKLNIEGTEKGNCGKDKDTWTQCN 591

  Fly   811 -------FLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISL---------Q 859
                   ||..|.:.::.:     |...||..|||.  ..:.....|...|.:.|         :
  Rat   592 KRDVLCGFLLCTNIGNIPR-----LGELDGEITSTL--VVQQGRTLNCSGGHVKLEEDVDLGYVE 649

  Fly   860 PGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVA---EWIVDNWYLVVLMGVAFI 921
            .|:||                   ||.:    :.|..:.|...:   ...:.|....|..|..
  Rat   650 DGTPC-------------------GPQM----MCLEHRCLPMASFNFSTCLSNKAGTVCSGNG-- 689

  Fly   922 VVMGSFIKC----------CAVHTPSSNPKKRRARRISETLRAPMNTLRRM-------------- 962
             |..:.:||          |..|.| .|...:....:|....|..|.:..:
  Rat   690 -VCSNELKCVCNRHWTGADCGTHFP-HNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGI 752

  Fly   963 --QRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRG-------GGGGGGGRHGGSRSHHQQH----- 1013
              ..:.|.|  ..|.:|    :..:..:.|||..       ||..........||....|
  Rat   753 TAWGYKNYR--EQRQLP----QGDYVKKPGDGDSFYSDFPPGGSADSASSSKKRSAFLSHFQIST 811

  Fly  1014 ----------------------PHDW-DRHQGGHSIVPLPTGG---SHSSRNSAANQARRSDGR- 1051
                                  .|.| :|......|..:...|   |:|.:.:.....::..|:
  Rat   812 CSITHYSISQNISLFCSRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNVGGNKKKIRGKR 876

  Fly  1052 -GPRSTSSGR-PQAIASG-SGAASGAARSHGGYGAEQAIPGSIGGGVQ---------------AA 1098
             .|||.|:.| |||...| |.|.:....|.||..:.|.  ||:....|               .:
  Rat   877 FRPRSNSTEREPQAPEPGHSLAQTSPGISPGGSDSPQT--GSLDHSTQDGQHQENRTLSPAKSPS 939

  Fly  1099 ISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQQPAI 1136
            .|:|.:.:..:.|.|:||...:::...:|..:|.:.:|
  Rat   940 SSTGSIASSRKYPYPMPPLPDEEKTVNRQSARLWETSI 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	34/152 (22%)
		Reprolysin_2	450..659	CDD:290307	30/129 (23%)
		Disintegrin	684..776	CDD:278623	30/95 (32%)
Adam22	XP_038964489.1	Pep_M12B_propep	70..185	CDD:396235
		Reprolysin	236..435	CDD:396140	33/144 (23%)
		DISIN	450..525	CDD:214490	30/97 (31%)
		ACR	527..668	CDD:214743	28/170 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920