DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam18

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_038950722.1	Gene:	Adam18 / 57029	RGDID:	620405	Length:	751	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	135/679 - (19%)
Similarity:	213/679 - (31%)	Gaps:	277/679 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 IWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYR--------------------N 466
            ||:..|:    .|:|...|.|:...:.:...:..|:....:::.                    |
  Rat   190 IWQTSRQ----LDKGHFREQDKNDSQLLPKSLKLHIIVGKFLFDYMGSDIMAVTQKIFQIIGLVN 250

  Fly   467 TKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDV--------SNFLNLHSLEDH 523
            |.|    ...|:...:..:::..|   :|..:...||     .|:        .::|...|.|
  Rat   251 TMF----TQLNLNVVLASLELWSD---KNQISTDGNA-----SDILQRLLGWKRDYLTPQSNE-- 301

  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGIC-EKY----KTYTETVGGQYQSTKRSLNTGI 583
                :.::..||..      |.::.:.|  .|.:| |.|    .||.|.:|.:..|
  Rat   302 ----ITHLLIYRKH------LKYIGATS--PGELCNESYVAGVGTYPEDIGLEGLS--------- 345

  Fly   584 ITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQEC---------RPGGLNGNYIMFASATSGD 639
                            :.:...||.:.|..:|....|         :|..|         ::||.
  Rat   346 ----------------MVITQLIGLHIGLTYDDVDNCSCPRAPCIMQPEAL---------SSSGM 385

  Fly   640 RPNNSKFSPCSIR---------------NISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEEC 689
            :    .||.||:.               ::||||.             .:.:.|||.|||..|||
  Rat   386 K----TFSNCSVHDYTHYASKLDMQCLGDLSNVLQ-------------PKQSVCGNGIVEGSEEC 433

  Fly   690 DCGFNEEECKDK-CCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQK 753
            ||| ||.||:.| ||              :.:.|..:...||  ..|.|| :..|..  ::....
  Rat   434 DCG-NETECQFKECC--------------NHETCKLKGSAQC--GSGTCC-TPKCEL--SAAGTP 478

  Fly   754 CKE--ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC------------SGSPCLL 804
            |::  :.||.::..|:|:::.|.......|..:|..|:|.|..|.|            .||....
  Rat   479 CRKAVDPECDFTEYCDGSSSHCVPDTFALDGHLCRLGSAYCYNGRCQALNDQCVSLFGKGSQGAS 543

  Fly   805 W-----------NMTKC-FLTSTTLPHVSKRKLC-DLAC-------------------------- 830
            :           |:..| ...|.:||...|..|| .|||
  Rat   544 YACFEKVNSQRENLANCDSKNSYSLPCGQKDVLCGKLACFRPNKNYKSSTQSVLYSYVHGSVCLS 608

  Fly   831 --------QDGNDTS-----------------TCRSTSEFADKYNIQK----GGISLQPGSPCDN 866
                    .||.|.:                 :|:..:...:..|..|    .||       |:|
  Rat   609 IPPGLSMRSDGKDNAYVADGTVCGPQMYCINGSCKEVNFTGNDCNAAKKCKGNGI-------CNN 666

  Fly   867 FQGYCDVFLKCRAVDA------------DGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVA 919
            | |:|..|...|..|.            ||.|||..:.|..::..|....|
  Rat   667 F-GHCQCFPDYRPPDCNLQIGSPGGSIDDGNLLRTDSALATKRLSQHADSW-------------- 716

  Fly   920 FIVVMGSFIKCCAVHTPSSNPKKRRARRI 948
              |::|.||....:.|......||..|:|
  Rat   717 --VILGFFIFLPFIMTLFLGIIKRNERKI 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	50/311 (16%)
		Reprolysin_2	450..659	CDD:290307	42/265 (16%)
		Disintegrin	684..776	CDD:278623	27/94 (29%)
Adam18	XP_038950722.1	Pep_M12B_propep	59..174	CDD:396235
		ZnMc_adamalysin_II_like	215..408	CDD:239797	39/256 (15%)
		Disintegrin	428..503	CDD:395147	27/94 (29%)
		ACR	507..645	CDD:214743	24/137 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339783
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850