DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam17

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_064702.2	Gene:	Adam17 / 57027	RGDID:	620404	Length:	827	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	206/938 - (21%)
Similarity:	332/938 - (35%)	Gaps:	319/938 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 ERLNEYISHYETLNYDHEHIRASHNRARRSVTKDQYVHLK----FASHGRDFHLRLKRDLNTFSN 95
            |:|:..:|.|:.|:..:....:...|..:|.|     ||:    |::..|.|.|.|......||.
  Rat    33 EKLDSLLSDYDILSLSNIQQHSIRKRDLQSAT-----HLETLLTFSALKRHFKLYLTSSTERFSQ 92

  Fly    96 KLD--FYDSK--GPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFP 156
            .|.  ..|.|  ....|.....:.|.|:|:.:|.|...|.:.....:|.|:...|.:|
  Rat    93 NLRVVVVDGKEESEYSVKWQDFFSGHVVGEPDSRVLAHIGDDDVTVRINTDGAEYNIE------- 150

  Fly   157 TNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEY 221

  Rat   151 ----------------------------------------------------------------- 150

  Fly   222 TESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQ 286
                        |...:..|.|::        ..::||...::| :..::...|.|
  Rat   151 ------------PLWRFVNDTKDK--------RMLVYKSEDIKD-FSRLQSPKVCG--------- 185

  Fly   287 WMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEA 351
                                                          |::.|.:...|.....:|
  Rat   186 ----------------------------------------------YLNADSEELLPKGLIDRE- 203

  Fly   352 NFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYI 416
                     ||              .:.|....|||..|..                ||||.|.:
  Rat   204 ---------PS--------------EEFVRRVKRRAEPNPL----------------KNTCKLLV 229

  Fly   417 QTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFE 481
            ..|...::::..|            :|.|   .|:.:...:..|:.|||||.:| ....:....:
  Rat   230 VADHRFYKYMGRG------------EEST---TTNYLIELIDRVDDIYRNTSWD-NAGFKGYGVQ 278

  Fly   482 VQRIKI----DDDSACRNSYNGPHNAFCNEH---MDVSNFLNLHSL---EDHSDFCLAYVFTYRD 536
            :::|:|    .:.......:| ...:|.||.   .||...|...||   |:.|..|||::|||:|
  Rat   279 IEQIRILKSPQEVKPGERHFN-MAKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQD 342

  Fly   537 FTGGTLGLAWVAS-ASGASGGICEKYKTYTETVGGQYQ-STKRS--LNTGIITFVNYNSRVPPKV 597
            |..||||||:|.| .:.:.||:|.|         ..|. ..|::  ||:|:.:..||...:..|.
  Rat   343 FDMGTLGLAYVGSPRANSHGGVCPK---------AYYNPGVKKNIYLNSGLTSTKNYGKTILTKE 398

  Fly   598 SQLTLAHEIGHNFGSPHDYPQ---ECRPG-GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVL 658
            :.|...||:|||||:.|| |.   ||.|. ...|.|:|:..|.|||..||..||.||.::|...:
  Rat   399 ADLVTTHELGHNFGAEHD-PDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTI 462

  Fly   659 DVLVGNTKRDCFKASEGAFCGNKIVESGEECDCG---FNEEECKDKCCYPRLISEYDQSLNSSAK 720
            :    :..::||:......|||..|:.|||||.|   .|    .|.||            ||.
  Rat   463 E----SKAQECFQERSNKVCGNSRVDEGEECDPGIMYLN----NDTCC------------NSD-- 505

  Fly   721 GCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKT 783
             ||.:...|||....|||  .:|.|  .:..:||:|  ...|...|.|.|.::|||.|...:|.|
  Rat   506 -CTLKPGVQCSDRNSPCC--KNCQF--ETAQKKCQEAINATCKGVSYCTGNSSECPPPGDAEDDT 565

  Fly   784 MCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSK-RKLCDLACQDGNDTS--TCRSTSEF 845
            :|.:      .|:|....|              :|...: ::|...||.|.:::.  .||:.|..
  Rat   566 VCLD------LGKCKAGKC--------------IPFCKREQELESCACADTDNSCKVCCRNLSGP 610

  Fly   846 ADKY-NIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLL------LNRKTLQTVA 903
            ...| :.::..:.|:.|.||.  .|:||:..||..        |:::::      :::.::.|..
  Rat   611 CVPYVDAEQKNLFLRKGKPCT--VGFCDMNGKCEK--------RVQDVIERFWDFIDQLSINTFG 665

  Fly   904 EWIVDNWY-LVVLMGVAFIVVMGSFIKC 930
            :::.||.. .|::..:.|.:.....:.|
  Rat   666 KFLADNIVGSVLVFSLIFWIPFSILVHC 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	87/284 (31%)
		Reprolysin_2	450..659	CDD:290307	77/226 (34%)
		Disintegrin	684..776	CDD:278623	32/96 (33%)
Adam17	NP_064702.2	Pep_M12B_propep	52..167	CDD:396235	29/211 (14%)
		Cysteine switch. /evidence=ECO:0000250	182..189		3/61 (5%)
		ZnMc_TACE_like	223..477	CDD:239798	87/284 (31%)
		DISIN	484..559	CDD:214490	32/97 (33%)
		ADAM17_MPD	581..642	CDD:406977	16/62 (26%)
		Crambin-like	603..671		15/77 (19%)
		SH3-binding. /evidence=ECO:0000255	731..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..827
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920