DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam4

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_064701.1	Gene:	Adam4 / 57022	RGDID:	621470	Length:	755	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	126/577 - (21%)
Similarity:	193/577 - (33%)	Gaps:	184/577 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 ELPEPMSKD-------YQKLHRKQ---LHKKSAPQQQQQPHPPKKYISGD-----EDFKY-PHQK 346
            ::|:.|.|.       |....|.|   :|.|.......|..|  .|.|.|     ||:.: |...
  Rat    52 KVPQRMGKSDMSGQITYSMRFRGQRHVVHMKLKKNMISQNFP--VYTSNDQGAQQEDYPFVPQDC 114

  Fly   347 YTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNT 411
            |          ||....|.. ||.|.:                    |..:.|..|..|.|: :|
  Rat   115 Y----------FYSYLEGVP-GSQATL--------------------DTCTGGLKGMIRVDD-ST 147

  Fly   412 CSLYIQTDPLIWRHIREGIADHDRGRKYEV---DEKTRE-----EITSLIAHHVTAVNYIYRNTK 468
            ..:...|....:.|:...:...:|.||.:.   ||...|     |.|.|......|..|::
  Rat   148 YEIKPLTSSSKFEHVISLLVVDERSRKSKKCRNDEIMAEAGDPLEETKLAGSPRAAPVYLW---- 208

  Fly   469 FDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFC----NEHMDVSNFLNLHSLED------- 522
                      |..|:.|.|        .|...|..|.    |:...:...|.::|:.|
  Rat   209 ----------RIHVKNIAI--------MYTVTHALFIQVGHNQTTSLELVLIMNSIADSIYRPSG 255

  Fly   523 ---------------------HSDFCLAYV--------FTYRDFTGGTLGLAWVASASGASGGIC 558
                                 :||..:..:        ..|.||...|..|     .||...|
  Rat   256 LIVFARAICIWNKQDNFNITEYSDSVIKLMEQFGYWKSTFYWDFPHATSAL-----LSGTKYG-- 313

  Fly   559 EKYKTYTETVGGQYQSTKRSLNTGII-TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRP 622
              .|.|     ..:|:...:.|.|:: |.|..|...   ::...::|.:||.|...||     :|
  Rat   314 --NKDY-----AAFQNGLCNPNWGVLYTHVGKNHFF---LAASLMSHAVGHIFNIGHD-----KP 363

  Fly   623 GGL---NGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVG-----NTKRDCFKASEGAF-- 677
            |.:   ..:.:|....|..|..:|     ||..|:.   :.::|     :..|..:|..:.|.
  Rat   364 GCVCFRRSSCVMSEFPTLLDMMSN-----CSHHNLH---EKIIGWDACLSQPRVAYKNFKYAVPR 420

  Fly   678 CGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNS 742
            ||||:|:..|:||||..::...:.||               ...|.....:.|  ::|.||  .|
  Rat   421 CGNKVVDDNEQCDCGTLKDCLSNHCC---------------GTNCQLIGSSTC--AEGLCC--QS 466

  Fly   743 CTFVPTSYHQKCKEETE-CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS 798
            |.|.||.  :.|:.... |.....|:|.:..||:..:..|.|.| :..|:|:.|.||
  Rat   467 CRFAPTG--KVCRHTNGICDLPEYCSGVSEHCPQNFYIMDGTPC-SPLAVCMSGNCS 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/323 (19%)
		Reprolysin_2	450..659	CDD:290307	48/252 (19%)
		Disintegrin	684..776	CDD:278623	23/92 (25%)
Adam4	NP_064701.1	Pep_M12B_propep	60..163	CDD:279848	28/136 (21%)
		ZnMc_adamalysin_II_like	213..405	CDD:239797	43/229 (19%)
		Reprolysin	213..394	CDD:279729	42/215 (20%)
		DISIN	427..501	CDD:214490	23/94 (24%)
		ACR	503..644	CDD:214743	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850