DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam1a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_064463.1	Gene:	Adam1a / 56777	RGDID:	621467	Length:	789	Species:	Rattus norvegicus

Alignment Length:	670	Identity:	147/670 - (21%)
Similarity:	208/670 - (31%)	Gaps:	262/670 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 GSGRGREDNKNTCSLYIQTDPLIWRHIRE----GIADHDRGRKYEVDEKTR-EEITSLIAHHVTA 459
            |....|:.:..|..|...:|  :|.|.:.    .:.:|.|.:.:..|..|. :.:..:||    .
  Rat   213 GDSSQRQGSSKTDELLALSD--LWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIA----L 271

  Fly   460 VNYIYRNTKFDGRTEHRNIRFEVQ------RIKIDDDSACRNSYNGPHNAFCNEHM------DVS 512
            .|...|..    .||...:..|:.      .:.:|..:..||     .|.:..|.:      ||:
  Rat   272 ANSFTRGI----NTEVVLVGLEIWTEGDPIEVPVDLQATLRN-----FNLWRQEKLMGRVRHDVA 327

  Fly   513 NFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKR 577
            :.:..|.                  .|...|.|::..|  .|||.....:.:.
  Rat   328 HLIVGHR------------------PGANEGQAFLDGA--CSGGFAAAVEAFH------------ 360

  Fly   578 SLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ-ECRPGGLNGNYIMF--ASATSGD 639
              :..::.|.            ..:|||:|||.|..||.|. .|.|..|   .:|.  .|.|||
  Rat   361 --HEDVLLFA------------ALMAHELGHNLGIRHDRPGCTCGPKHL---CLMHETISKTSG- 407

  Fly   640 RPNNSKFSPCSIRNISNVLDVLVG-----------NTKRDCFKASEGAFCGNKIVESGEECDCGF 693
                  ||.||..:....|....|           :.:||       |.|||.:||..||||||
  Rat   408 ------FSNCSSDHFLRFLHDHRGACLLDRPWHQSHKRRD-------AHCGNGVVEESEECDCG- 458

  Fly   694 NEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-E 756
              ..| ...||.|.               ||.:...||  |:|.||.  .|||....  ..|: .
  Rat   459 --NACDSHPCCEPT---------------CTLKVGAQC--SEGLCCY--KCTFKKKG--TLCRPA 500

  Fly   757 ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS----------GSP-------CLL 804
            |..|.....|||.|.|||...:..|.|.|:. ...|..|.|.          |.|       |.:
  Rat   501 EDVCDLPEYCNGITGECPANSYMQDGTQCDR-IYYCSGGLCKNPDKQCARIYGYPARSAPEECYI 564

  Fly   805 WNMTKC-------FLTSTTLPHVSKRKLCD--------LACQD------------------GNDT 836
            ...||.       ..||..|    |.:.|.        |.|.|                  |:|
  Rat   565 SVNTKANRFGNCGHPTSANL----KYEACSNEDIFCGKLVCTDVRYLPQVKPLHSLLQIPYGDD- 624

  Fly   837 STCRSTSEFADKYNIQ--------KGGISLQPGSPC--------------------DNFQGYCDV 873
             .|.|    .|.||:.        :||....|...|                    .:..|.|:.
  Rat   625 -WCWS----MDAYNVTDIPDYGDVQGGTYCAPKKVCMESICTGHATLQYDCHPQEMCHGNGVCNN 684

  Fly   874 FLKCR-----------------AVDADGPLLRL--KNLLL--------NRKTLQTVAEWIVDNWY 911
            |..|.                 :||: ||:.:.  :||.|        :|...:.:      |..
  Rat   685 FKHCHCDAGFSPPDCSSGGNGGSVDS-GPVGKPADRNLSLFGVGESPDSRMEDEEI------NLK 742

  Fly   912 LVVLMGVAFIVVMGSFIKCC 931
            :|||:...|::|    :.||
  Rat   743 VVVLVVPIFLIV----LLCC 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	58/297 (20%)
		Reprolysin_2	450..659	CDD:290307	45/223 (20%)
		Disintegrin	684..776	CDD:278623	32/93 (34%)
Adam1a	NP_064463.1	Pep_M12B_propep	79..194	CDD:396235
		Reprolysin	238..432	CDD:396140	51/262 (19%)
		DISIN	450..522	CDD:214490	32/95 (34%)
		ACR	524..660	CDD:214743	30/146 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920