Protein Alignment kuz and Adam21

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_065063.1
• Gene: Adam21 / 56622
• MGIID: 1861229
• Length: 729
• Species: Mus musculus
• Alignment Length: 547
• Identity: 133/547 - (24%)
• Similarity: 180/547 - (32%)
• Gaps: 231/547 - (42%)

  Fly   436 GRKYEVDEKTREEITSLIAHHVTAVNYIY----RNTKFD----GRTEHRNI--RFEVQRIKIDDD 490
            |..||::.         |.|..|..:.:|    ..|:|.    ..||.|.:  .|.|:..|   .
Mouse   145 GFSYEIEP---------IKHSSTFEHLVYTLNNNKTQFPPMLCSLTEKRLLYQPFGVEEAK---K 197

  Fly   491 SACRNSYN--GPH------------NAFCNEHMDVS----------------------------- 512
            ||.:.:|.  .||            ..|.|...::|
Mouse   198 SAMKQNYGKLWPHMWFLELAVVVDYGFFTNAQQNLSKVRGDVVLVVNMVDSMYKPLDTYVTLVGI 262

  Fly   513 ------NFL---NLHS-LED------------HSDFCLAYVFTYRDFTGGTLGLAWVASASGASG 555
                  |.|   |:|. |||            |.|  .|::| .|......||:|::|
Mouse   263 EIWNRGNVLPMENIHQVLEDFSHWKQISLSQVHHD--AAHIF-IRSSLISVLGIAYIA------- 317

  Fly   556 GICEKYKTYTETVGGQYQSTKRSLNTGI--------ITFVNYNSRVPPKVSQLTLAHEIGHNFGS 612
            |||                 :..|:.|:        ..|.|            |:|||:||.||.
Mouse   318 GIC-----------------RPPLDCGVENFQGDAWSLFAN------------TVAHELGHTFGM 353

  Fly   613 PHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFS----------PCSIRNISNVLDVLVGNTKR 667
            .|| .:.|..|  ....:|.......:|..|..:|          .|...:.......||   ||
Mouse   354 KHD-EESCSCG--KSGCVMSTFRVPAERFTNCSYSDFMKTTLNQGTCLYNHPRPGAGFLV---KR 412

  Fly   668 DCFKASEGAFCGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCS 731
                      |||.:|||.|||||| :.:|| :|.||:          ||     ||.|....|
Mouse   413 ----------CGNGMVESEEECDCG-SVQECEQDPCCF----------LN-----CTLRPAAAC- 450

  Fly   732 PSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRG 795
             |.|.||  ..|.|:...  :.|:.: .||.....||||:.:|||..:..|...|..| |.|.:.
Mouse   451 -SFGLCC--KDCKFMLLG--ELCRPKINECDLPEWCNGTSHQCPEDGYVQDGVPCGAG-AYCYQK 509

  Fly   796 ECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQD--GNDTSTCRSTSEFADKYNIQKGGISL 858
            :|:..                          |..|::  |..   .||.|     :|..| .|:|
Mouse   510 QCNNH--------------------------DQQCREIFGKG---ARSAS-----HNCYK-EINL 539

  Fly   859 QPGSPCDNFQGYC----DVFLKCRAVD 881
            |     .|..|:|    .||||||..|
Mouse   540 Q-----GNRFGHCGTDGTVFLKCRMSD 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	67/333 (20%)
		Reprolysin_2	450..659	CDD:290307	60/301 (20%)
		Disintegrin	684..776	CDD:278623	34/93 (37%)
Adam21	NP_065063.1	Pep_M12B_propep	55..163	CDD:279848	6/26 (23%)
		Cysteine switch. /evidence=ECO:0000250	176..183		1/6 (17%)
		ZnMc_adamalysin_II_like	212..400	CDD:239797	43/229 (19%)
		Reprolysin	213..402	CDD:279729	43/230 (19%)
		Disintegrin	419..491	CDD:278623	34/93 (37%)
		ACR	495..631	CDD:214743	27/108 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850