DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam10a

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_005168953.1	Gene:	adam10a / 566044	ZFINID:	ZDB-GENE-040917-2	Length:	763	Species:	Danio rerio

Alignment Length:	1002	Identity:	348/1002 - (34%)
Similarity:	488/1002 - (48%)	Gaps:	275/1002 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 IIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVT-KDQYVHLKFAS 77
            ::|.:::..|....|..:.| :.||:||.|||.|:||.:.:.:.|.||:|::: :||::||:|.:
Zfish     7 VLFKLLILLYCLSDSNGQYG-KPLNKYIRHYEGLSYDTDVLHSKHQRAKRALSHQDQFIHLEFHA 70

  Fly    78 HGRDFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITE 142
            |||.|:||:|||.:.|::.|....|...:...|.|||.||:.|:::|...||:.:|.|||.|.:.
Zfish    71 HGRHFNLRMKRDTSLFTHNLKVEVSGVEVPYDTSHIYTGEIYGEKDSLTHGSVVDGKFEGFIKSH 135

  Fly   143 RDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKK 207
            ...||||
Zfish   136 HGTYYVE---------------------------------------------------------- 142

  Fly   208 IAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVRE 272
                                      |:..|.:|:       .:.:||:||.|..::..::...|
Zfish   143 --------------------------PSERYLKDQ-------NVPYHSVIYHEDDIDYPHKYGSE 174

  Fly   273 GHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGD 337
            |   ||. ...|.:.|:..|.||:||                      |.||      ..:|..:
Zfish   175 G---GCA-DHSVFERMKKYQASAMEE----------------------PTQQ------TNHIIDE 207

  Fly   338 EDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSG 402
            |                                  |||...::  |.|||.
Zfish   208 E----------------------------------VADGPVIL--RTRRAA-------------- 222

  Fly   403 RGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNT 467
               :..||||.|:||||.|.:::.                 .:||.:.:.|:.||.|:|.||:.|
Zfish   223 ---QAEKNTCQLFIQTDHLFFKYY-----------------GSREAVIAQISSHVKAINSIYQGT 267

  Fly   468 KFDGRTEHRNIRFEVQRIKI-----DDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFC 527
            .|.|   .|||.|.|:||||     :.||:         |.|...::.|..||.|:|.::|.::|
Zfish   268 DFQG---IRNISFMVKRIKINTTIDEKDSS---------NPFRFGNIGVEKFLELNSEQNHDEYC 320

  Fly   528 LAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSR 592
            ||||||.|||..|.||||||.:.||:|||||||.|.|::       ..|:||||||||..||.|.
Zfish   321 LAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKNKQYSD-------GKKKSLNTGIITVQNYASH 378

  Fly   593 VPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGL-------NGNYIMFASATSGDRPNNSKFSPCS 650
            ||||||.:|.|||:|||||||||...:|.||..       .|||||:|.|||||:.||:|||.||
Zfish   379 VPPKVSHITFAHEVGHNFGSPHDSGSDCTPGESKTTDQKEKGNYIMYARATSGDKFNNNKFSICS 443

  Fly   651 IRNISNVLDVLVGNTKRD-CFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQS 714
            :||||.|||     .||. ||..|....|||.:||:.||||||:| ::|||:|||        .:
Zfish   444 VRNISQVLD-----KKRSACFVESGQPICGNGLVETNEECDCGYN-DQCKDQCCY--------SA 494

  Fly   715 LNSSAKGCTRRAKTQ------CSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAEC 773
            .....|.|..:.:|:      ||||||||| :..||:   ....:|:.|::|::...|||.:|:|
Zfish   495 DEPEGKKCKLKPETESKSKVFCSPSQGPCC-TPQCTY---RTGNECRPESDCAFKGLCNGLSAQC 555

  Fly   774 PEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTST 838
            |....:::.|.|:..|.:||.|.||||.|....:..|  |..|.......:||.:.|.:....||
Zfish   556 PASTPKENYTACHANTQVCINGGCSGSICEKHKLDVC--TCATEDGKDDMELCHVCCMEKGKPST 618

  Fly   839 CRSTSE------FADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRK 897
            |.|||.      |.:|.      |:|||||||::|:||||||:|||.|||||||.|||..:.|.:
Zfish   619 CSSTSSERWASFFDNKV------ITLQPGSPCNDFKGYCDVFMKCRLVDADGPLARLKKAIFNPE 677

  Fly   898 TLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRM 962
            ...::|||||.:|:.|:|||:|.|::|..|||.|:|||||||||....:.:..||:      ||.
Zfish   678 LYTSIAEWIVKHWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTLK------RRR 736

  Fly   963 QRHPNQRGAGPRSIPPPAHEAQHYSRG 989
            .::|:.:....|    |..:.::|..|
Zfish   737 AQNPSAQTQPQR----PRQQRENYQMG 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	132/279 (47%)
		Reprolysin_2	450..659	CDD:290307	114/220 (52%)
		Disintegrin	684..776	CDD:278623	37/97 (38%)
adam10a	XP_005168953.1	Pep_M12B_propep	54..151	CDD:279848	39/180 (22%)
		ZnMc_TACE_like	227..466	CDD:239798	132/279 (47%)
		Reprolysin_2	247..452	CDD:290307	115/223 (52%)
		DISIN	473..559	CDD:214490	37/98 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	583	1.000	Inparanoid score	I975
OMA	1	1.010	-	-		QHG48710
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006327
OrthoInspector	1	1.000	-	-		otm26226
orthoMCL	1	0.900	-	-		OOG6_104685
Panther	1	1.100	-	-	O	PTHR45702
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3274
SonicParanoid	1	1.000	-	-		X3482
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010