Protein Alignment kuz and adam19a

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_005172418.1
• Gene: adam19a / 565342
• ZFINID: ZDB-GENE-070813-1
• Length: 944
• Species: Danio rerio
• Alignment Length: 1138
• Identity: 233/1138 - (20%)
• Similarity: 342/1138 - (30%)
• Gaps: 450/1138 - (39%)

  Fly   211 STTTSQQLPEYTESSSSSTTTFPPTTEYF---ED-----EKERNAEDELDFHSIIYKESHVEDAY 267
            |.:|:||.||.|....     ||.:.|..   :|     :.|||  .||..|.  :.|:|.|:..
Zfish    53 SHSTAQQEPETTFKDK-----FPESGEILVSAQDLELVLQVERN--QELLGHD--FTETHYENGL 108

  Fly   268 ENVREG-HVAGC----GITDEVSQWME----------NIQNSAVEELPEPMSKDYQKLHRKQLHK 317
            ...:.. |...|    .:......|:.          .:.||......||: :..:.:|......
Zfish   109 PITQSSHHTDHCFYHGRVRGHADSWVALSTCLGMRGLIVLNSNDTFYLEPI-RGQEVVHHAFYRT 172

  Fly   318 KSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHE 382
            :..|.:           ||    ...|..:|.:.:...|.|                   :.:|:
Zfish   173 EDLPIK-----------SG----TCGHSHHTGQMSLFSGDF-------------------KPLHQ 203

  Fly   383 RVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVD-EKTR 446
            ||||          ::.|:.:..|       |||             :||:...||...| :||:
Zfish   204 RVRR----------NAWGTTKYME-------LYI-------------VADNTLYRKQNKDLDKTK 238

  Fly   447 EEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKID---DDSACRNSYNGPHNAFCNEH 508
            ..|..:       .||:   .||     :|.:...|..|.::   :...|          ..||.
Zfish   239 LRIMEI-------ANYV---DKF-----YRELNIRVPLIGLEVWTEHDQC----------IINEE 278

  Fly   509 MDVS--NFL----NLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTET 567
            .:.:  :||    .|.|.:.|.:   |.:.|...|.|.|:|:|.:.       |:|..     |.
Zfish   279 PNSTLWSFLQWRQKLKSRKKHDN---AQLLTGVIFKGTTIGMAPLE-------GMCSH-----EN 328

  Fly   568 VGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMF 632
            .||                :|.:....|..:..|:|||||||||..||:...|..........:.
Zfish   329 SGG----------------INVDHSELPIGAAATMAHEIGHNFGMSHDHEGCCVEATAEQGGCVM 377

  Fly   633 ASATSGDRPNNSKFSPCS---------------IRNISNVLDVLVGNTKRDCFKASEGAFCGNKI 682
            |:||.  .|....||.||               :.|:.|:.| |||           |..|||..
Zfish   378 AAATG--HPFPKVFSRCSKKDLDNYFQKGGGMCLFNMPNMKD-LVG-----------GKRCGNGF 428

  Fly   683 VESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVP 747
            ||.||||||| ..|||.:.||:|              ..||.:...||  :.|.||
Zfish   429 VEEGEECDCG-EPEECTNDCCHP--------------SNCTLKVDAQC--AHGVCC--------- 467

  Fly   748 TSYHQKCKEET----------ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGS 800
                :.||.:.          .|.....|.|.:..||...:..|.:.|..|.|.|..|.|  ...
Zfish   468 ----EGCKLKQAGTMCRGPAGACDLPEYCTGGSPYCPSNVYLLDGSSCQYGRAYCYNGMCLTHEQ 528

  Fly   801 PCL-LW-------------------------------NMTKCFLTSTTLPHVSKRKLCDLACQDG 833
            .|| ||                               |..||..:......:.    |..|.:..
Zfish   529 QCLQLWGYGAQPAHDACFQDVNAAGNAFGNCGKDSKGNYMKCEKSDAKCGKIQ----CHSAAKKP 589

  Fly   834 NDTST---------------CRSTSEFADKYNIQKG------------GISLQPGSPCDNFQ--- 868
            ..|:.               ||.|  |.  |:.|.|            |.....|..|.:.:
Zfish   590 KGTNAVSIDTTIQTDGIEVKCRGT--FV--YSTQDGQGDLPDPGLVMTGTKCGEGKVCKDRRCQN 650

  Fly   869 ----------------GYCDVFLKCR-----------------AVDADGPLLRLKNLLLNRKTLQ 900
                            |.|:....|.                 :||: ||:.
Zfish   651 TSFTELESCIVRCHGHGVCNSNGNCHCSRGWAPPFCEKPGLGGSVDS-GPVQ------------- 701

  Fly   901 TVAEWIVDNWY-LVVLMGVAFIVVMGSFIKC--CAVHTPSSNPKKRRARRISETLRAPMNTLRRM 962
                  .|:.. |||.:..||:|::.:.:..  |.....|...|.|:.|..|:..|...:|.:..
Zfish   702 ------YDSQVGLVVGLLFAFLVLLPAVLIAFYCVKIKSSYYHKWRKQREKSKASRHDTSTEKGK 760

  Fly   963 QRHPNQ----RGAGPRSIPPPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGG 1023
            ..|.|.    :..||                               .:|:.:.:.||.      .
Zfish   761 NGHLNPAFHLKVVGP-------------------------------NNRNANIKLPHT------S 788

  Fly  1024 HSIVPL---PTGGSHSSRN-----SAANQARRSDGRGPR--------STSSGRPQAIASGSGAAS 1072
            ..::||   |........|     ..|.....|:.:|||        ..|...|:.:||....:.
Zfish   789 KEVLPLRPNPATNGPQPVNIVRPLRPAPSPSLSNMKGPRPPPPISKPPNSPKTPKTVASPQKLSP 853

  Fly  1073 -------GAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQ 1130
                   ..:|:......:|..|.|               ...|.||||.|..|.|.......|.
Zfish   854 PKKPLPLNPSRTPLMVSQQQPRPPS---------------TPPQRPLPLSPARGAQPRSSSGGLM 903

  Fly  1131 -LQQPAISPQQ-------QPQQAFYT---PKEL 1152
             :..||:.|:.       .|.:||..   ||.|
Zfish   904 VMMPPAVGPKPVGKVTAVPPLKAFQPASGPKPL 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	68/291 (23%)
		Reprolysin_2	450..659	CDD:290307	52/232 (22%)
		Disintegrin	684..776	CDD:278623	28/101 (28%)
adam19a	XP_005172418.1	Pep_M12B_propep	77..158	CDD:279848	15/84 (18%)
		Reprolysin	214..413	CDD:279729	63/276 (23%)
		ZnMc_adamalysin_II_like	214..411	CDD:239797	62/274 (23%)
		Disintegrin	440..503	CDD:278623	20/91 (22%)
		ACR	506..651	CDD:214743	27/152 (18%)
		EGF_2	<663..686	CDD:285248	3/22 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010