DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and si:ch1073-396h14.1

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_689465.6	Gene:	si:ch1073-396h14.1 / 560975	ZFINID:	ZDB-GENE-070705-6	Length:	683	Species:	Danio rerio

Alignment Length:	937	Identity:	258/937 - (27%)
Similarity:	374/937 - (39%)	Gaps:	289/937 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NIVFVSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARRSVTKD-QYV 71
            |...:.::..|:..|:..:.|      :.:::||.|||.|:||.|.::...:|.||....: |.:
Zfish     7 NAARICLLIYILSRGHFTEAS------QAISKYIKHYEGLSYDRELVKQHQHRIRRDANPNKQDL 65

  Fly    72 HLKFASHGRDFHLRLKRDLN---TFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNG 133
            ||.|::..|:|||||..|:|   |...|:...:....:|:|  |||.|.:..|..|...||:..|
Zfish    66 HLDFSAFQREFHLRLTPDVNNGFTEDFKVQSENESQMVDLS--HIYSGVLEDDSKSSCQGSVLEG 128

  Fly   134 VFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVN 198
            .|||.|.|....:|||..:.|              .||.|
Zfish   129 QFEGSITTSNGTFYVEPIERY--------------KTTHS------------------------- 154

  Fly   199 SKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHV 263
                                                                 |.|||||.|..|
Zfish   155 -----------------------------------------------------DHHSIIYHEDDV 166

  Fly   264 EDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPH 328
            :|.  .:|.||...||     ::.::|:..:..|::|...||
Zfish   167 DDT--PLRSGHAGFCG-----AERLQNLLQNHQEQIPVSRSK----------------------- 201

  Fly   329 PPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAG 393

Zfish   202 ----------------------------------------------------------------- 201

  Fly   394 DRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVT 458
                     |..:.:|.:|.|::.||                 .:|.....:.|.|.:.:|.::.
Zfish   202 ---------RKVDQSKTSCLLHLHTD-----------------HRYYKRFGSIEAIVAQVASYMK 240

  Fly   459 AVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDH 523
            |||.:|....||| .|..|.:.:...:..::|         |.:.....|:.....|:|.|..:.
Zfish   241 AVNDVYDKANFDG-IELINFKVKFLTVITEED---------PSSPISVTHVGPEKLLSLFSETNW 295

  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN 588
            :||||:|:.|.|||: |.|||||...|.. .||||.|....:        ....|.|||::|...
Zfish   296 NDFCLSYLLTDRDFS-GVLGLAWEGKADN-WGGICSKMILKS--------GRNCSHNTGLVTLQT 350

  Fly   589 YNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGL-----NGNYIMFASATSGDRPNNSKFSP 648
            |...:..|...||.|||:||:.|:|||....|  |.|     .|.::||..|.|....|:.||||
Zfish   351 YGHYLSTKHVHLTFAHELGHSLGAPHDENSNC--GDLEVTSGKGRFLMFPKAASRIEENSDKFSP 413

  Fly   649 CSIRNISNVLDVLVGNTKRD-CFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYD 712
            ||:|::|::|     |.|:| ||..|:...|||:|||.|||||.|.::   .|.||:
Zfish   414 CSLRHMSHLL-----NVKKDTCFVDSDQPICGNRIVEEGEECDVGHDD---SDPCCH-------- 462

  Fly   713 QSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPR 777
            .|...|...|..:...|||||||.|| ::.|.|.....  .|:..:||...|.|.|::|.||||.
Zfish   463 SSKEPSGIECRLKLGKQCSPSQGLCC-NSQCVFKKAGL--MCEGNSECRNKSVCAGSSAVCPEPP 524

  Fly   778 HRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRST 842
            .:.|.|:|:|||.:|..|||..|.|.|.||.:|     ..|..||.:.|.:.||..:..:||.||
Zfish   525 SKPDMTICSNGTRVCSSGECGLSLCALHNMVQC-----DCPGQSKTEKCHMCCQQRDKPNTCAST 584

  Fly   843 SE------FADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQT 901
            :.      |:.|      .::|.||:||...|||||.|..||.:|||||:.||||..|.......
Zfish   585 TSAVLLQYFSGK------RVALAPGAPCSGNQGYCDQFKVCRILDADGPIARLKNSFLKLDEFDD 643

  Fly   902 VAEWIVDNWYLVVLMGVAFIVVMGSFI 928
            :|.|:..:|:.::|..::...:||..|
Zfish   644 LAGWMKAHWWAILLGILSISAIMGGTI 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	86/272 (32%)
		Reprolysin_2	450..659	CDD:290307	72/213 (34%)
		Disintegrin	684..776	CDD:278623	33/91 (36%)
si:ch1073-396h14.1	XP_689465.6	Pep_M12B_propep	55..156	CDD:279848	39/194 (20%)
		ZnMc	209..438	CDD:294052	86/272 (32%)
		Reprolysin_2	228..424	CDD:290307	75/222 (34%)
		Disintegrin	445..523	CDD:278623	33/91 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920