DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam17b

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_021324312.1	Gene:	adam17b / 560657	ZFINID:	ZDB-GENE-041001-199	Length:	843	Species:	Danio rerio

Alignment Length:	1082	Identity:	266/1082 - (24%)
Similarity:	381/1082 - (35%)	Gaps:	356/1082 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 KKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENV 270
            |:..:|.|.:::|..:|.............||.|..          ||.:::..|...::.||..
Zfish    54 KRDVQSQTHAERLLGFTALQRHFKLYLTTNTELFTH----------DFKAVVVGEDGAQEVYEVQ 108

  Fly   271 RE----GHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPK 331
            ||    |||.|             .:||.|                             |.|
Zfish   109 RENFFTGHVIG-------------EENSRV-----------------------------QAH--- 128

  Fly   332 KYISGDEDF---------KY---PHQKYTKEANFAEGAFYDPSTGRRLGSSANV-------ADWH 377
               .||.||         :|   |..::|:..:.:....|.....|.:...|..       ||..
Zfish   129 ---IGDNDFTAHILTDEAEYNIEPLWRFTENTHDSRLLVYRSEDIRNVSRLAATKVCGYVSADAS 190

  Fly   378 QLVHE--RVRRATDNGAGDRGSSGGSGRGR----EDNKNTCSLYIQTDPLIWRHIREGIADHDRG 436
            :::.|  ||.||.|.   |.....|..|.|    :.:||||.|.:..|...::|:         |
Zfish   191 EVLPESVRVSRALDE---DHQEEEGQVRERRQTVDHSKNTCPLLLVADYRFFKHM---------G 243

  Fly   437 RKYEVDEKTREEITSL--IAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRI-------KIDDDSA 492
            ||        ||.|:|  :...:..|:.|||||.:|  .|::....::|:|       :::...|
Zfish   244 RK--------EESTTLNYLIELIDRVDDIYRNTSWD--DEYKGYGVQIQQIIINMTPTQVEPGGA 298

  Fly   493 CRNSYNGPHNAFCNEHM-DVSNFLNLHSL---EDHSDFCLAYVFTYRDFTGGTLGLAWVA-SASG 552
            ..|....|..   :::: ||...|...|:   ::.|..|||::|||:||..||||||:|| |..|
Zfish   299 HFNMKGTPVK---DKYVWDVKKLLEQFSIDIADNASQVCLAHLFTYQDFDEGTLGLAYVAPSKPG 360

  Fly   553 ASGGIC-EKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDY 616
            ..||:| ||...........|      ||||:.:..||...:..|.:.|...||:|||||:.||
Zfish   361 FPGGLCSEKCPPSGNDNRAIY------LNTGLTSTKNYGKTILTKEADLVTTHELGHNFGAVHD- 418

  Fly   617 PQE---CRP-GGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAF 677
            |.:   |.| ....|.|:|:..|.|||..||..||.||..:|:..|......    |||......
Zfish   419 PDDMSYCAPREDQGGKYVMYPIAVSGDHTNNKLFSNCSKMSIAKRLRAKAST----CFKERNSNV 479

  Fly   678 CGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNS 742
            |||..||.|||||.|..... .|.||               ...|..:...|||....|||  ..
Zfish   480 CGNSRVEEGEECDPGLLHLN-SDLCC---------------TANCKLKPGVQCSDRNSPCC--KD 526

  Fly   743 CTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKTMC-NNGTALCIRGECSGSPCLL 804
            |.|  ...::.|:|  |..|...|.|:|..:|||.|.:..:||:| :||.  |:.|||......:
Zfish   527 CRF--EKQNKVCQEPMEATCKGRSNCSGYGSECPPPENLPNKTICVDNGR--CLNGECIPFCEAV 587

  Fly   805 WNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGG-ISLQPGSPCDNFQ 868
            .|:..|....|   |.|    |.:.|:|.|  ..|.       .|...||. :.|:.|.||.  .
Zfish   588 KNLQSCACNET---HNS----CKVCCKDKN--GVCA-------PYIGDKGSPLFLRKGKPCT--V 634

  Fly   869 GYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWY-LVVLMGVAFIVVMGSFIKCCA 932
            |:||...||.....| .:.||.: .:.:..:.|..:::.||.. .||:..:.|.:.:...:.|.
Zfish   635 GFCDGAGKCMKQVQD-VIERLWD-FIEKLDINTFGKFLADNIVGSVVVFSLLFWIPLSILVHCV- 696

  Fly   933 VHTPSSNPKK--RRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGG 995
                   .||  ::....::.|..|.|.    :...:...|..|...||:
Zfish   697 -------DKKLDQQYELSTKPLFYPSNA----ELLSSLESASVRIFKPPS--------------- 735

  Fly   996 GGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRSDGRGPRSTSSGR 1060
                                     ..|.|:||                  |....||..||: .
Zfish   736 -------------------------SAGSSVVP------------------RFHACGPLQTST-P 756

  Fly  1061 PQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQ 1125
            |.:|:                   |..|..|                 |.|.|.|.||
Zfish   757 PVSIS-------------------QVAPAPI-----------------QTPTPCPLPN------- 778

  Fly  1126 QQQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVSGPGS 1190
                      |.||:..     |.||.|    |..|..:........|        |||||
Zfish   779 ----------IEPQRMA-----TIKEDP----SYDSHLDQVLGEDFPT--------SGSVS---- 812

  Fly  1191 GAGSSSKSKSGKSAKAKDSKSQKSQQANNSR------SSSKE 1226
                          ::.|..::..:.|.:.|      |:|||
Zfish   813 --------------RSFDDLTENRENAMSFRVNRHPQSNSKE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	93/285 (33%)
		Reprolysin_2	450..659	CDD:290307	78/227 (34%)
		Disintegrin	684..776	CDD:278623	29/93 (31%)
adam17b	XP_021324312.1	Pep_M12B_propep	46..150	CDD:307618	29/153 (19%)
		ZnMc_TACE_like	226..479	CDD:239798	93/285 (33%)
		Disintegrin	486..560	CDD:306668	29/93 (31%)
		ADAM17_MPD	583..643	CDD:318829	20/77 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920