DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam39

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001020551.3	Gene:	Adam39 / 546055	MGIID:	3045694	Length:	756	Species:	Mus musculus

Alignment Length:	322	Identity:	83/322 - (25%)
Similarity:	114/322 - (35%)	Gaps:	94/322 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   494 RNSYNGPH-NAFCNEHMD-VSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGG 556
            :|...|.: |.|..|..| .:..||.....|     :|::|...||. ..||:|:|       ||
Mouse   277 KNHVQGRNINEFLVEFCDWKARSLNFRIPND-----IAHIFVNLDFQ-IYLGVAYV-------GG 328

  Fly   557 ICEKYKTYTETVGGQYQSTKRSLNTGIITFVN----YNSRVPPKVSQLTLAHEIGHNFGSPHDYP 617
            :|                 ..|.|.|:...:.    |...:        :|||||||.|..|| .
Mouse   329 VC-----------------LPSYNCGVDCLLGGNLFYFGHI--------IAHEIGHNLGMEHD-S 367

  Fly   618 QECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKAS--------- 673
            ..|..|   .|..:.|.|.:|    .||||.||.....         ||....|..
Mouse   368 SSCTCG---RNVCLMAPADNG----ISKFSNCSYSYFW---------TKYPTAKCMHKEKKSIGI 416

  Fly   674 -EGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPC 737
             .|..||:.:|:.||:||||..:....|.||               .:.||.:....|  :.|.|
Mouse   417 LRGKLCGDGVVDDGEQCDCGSAKNCADDPCC---------------KRSCTLKDGAAC--AFGLC 464

  Fly   738 CLSNSCTFVPTSYHQKC-KEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS 798
            |  ..|..:...  ..| |.:.||.....|||.:.:||...:..|.:.|.:| ..|....|:
Mouse   465 C--KYCQIMEAG--TVCRKRDNECDLPEWCNGHSHKCPNDVYLLDGSPCRDG-GYCYEKRCN 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	50/198 (25%)
		Reprolysin_2	450..659	CDD:290307	46/170 (27%)
		Disintegrin	684..776	CDD:278623	25/92 (27%)
Adam39	NP_001020551.3	Pep_M12B_propep	69..173	CDD:279848
		Reprolysin	222..409	CDD:279729	49/186 (26%)
		ZnMc_adamalysin_II_like	222..408	CDD:239797	49/185 (26%)
		Disintegrin	428..501	CDD:278623	25/93 (27%)
		ACR	504..640	CDD:214743	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920