DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM22

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_006716091.1	Gene:	ADAM22 / 53616	HGNCID:	201	Length:	1024	Species:	Homo sapiens

Alignment Length:	793	Identity:	154/793 - (19%)
Similarity:	241/793 - (30%)	Gaps:	316/793 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 LEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGII 584
            :::.||  ..::|:...|.....|.|::       ||||...|.     ||..:..|..|
Human   372 IKEKSD--AVHLFSGSQFESSRSGAAYI-------GGICSLLKG-----GGVNEFGKTDL----- 417

  Fly   585 TFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ----ECR-----PG---GLNGNYIMFASATS 637
                         ..:|||..:.||.|...|..:    ||:     .|   |..|.|:
Human   418 -------------MAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYL------- 462

  Fly   638 GDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCF-----KASEGAFCGNKIVESGEECDCGFNEEE 697
                 ..||:.|:|....:.|:...|    .|.     |..:...|||..:|:||||||| ...|
Human   463 -----PKKFTQCNIEEYHDFLNSGGG----ACLFNKPSKLLDPPECGNGFIETGEECDCG-TPAE 517

  Fly   698 C---KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-T 758
            |   ..:||                |.||....:||  |.|.||  ..|.|.|..  ..|:|. .
Human   518 CVLEGAECC----------------KKCTLTQDSQC--SDGLCC--KKCKFQPMG--TVCREAVN 560

  Fly   759 ECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWNMT------------ 808
            :|....||:|.:::|....|:.|...|:....:|..|.|.  ...| .:|...
Human   561 DCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKL 625

  Fly   809 --------KCFLTSTTLPHVSKRK-LCD-LACQ-----------DGNDTSTCRSTSEFADKYNIQ 852
                    .|.....|....:||. ||. |.|.           ||..|||.  ..:.....|..
Human   626 NIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTL--VVQQGRTLNCS 688

  Fly   853 KGGISL---------QPGSPCD----------------NF--------------QGYCDVFLKC- 877
            .|.:.|         :.|:||.                ||              .|.|...|||
Human   689 GGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCV 753

  Fly   878 ---------------------RAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAF- 920
                                 ..:...|..:...|:::.     .:|..|:   .|.:::|:..
Human   754 CNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIG-----IIAGTIL---VLALILGITAW 810

  Fly   921 ---------IVVMGSFIK------------CCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQR 964
                     .:..|.::|            ...|.|.|::..|:|:..:|.:.         .:|
Human   811 GYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSW---------SER 866

  Fly   965 HPNQRGAGPRSIPPPAHEAQHYS--------RGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRH- 1020
            .|               :.:|.|        |....:|..||...:..|.|...:.:..:.:..
Human   867 IP---------------DTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTEREPQA 916

  Fly  1021 -QGGHSI---VP---LPTGGSHSSRNSAA-------------NQAR-----RSDGRGP--RSTSS 1058
             :.|||:   ||   :..|||.|.:..:.             |.|:     ..:..||  |:.|.
Human   917 PEPGHSLAQTVPSQGISPGGSDSPQTGSLDHRYLNPWFKRDYNVAKWVEDVNKNTEGPYFRTLSP 981

  Fly  1059 GRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQM 1123
            .:.                          |.|         |:|.:.:..:.|.|:||...:.:.
Human   982 AKS--------------------------PSS---------STGSIASSRKYPYPMPPLPDEDKK 1011

  Fly  1124 QQQQQLQLQQPAI 1136
            ..:|..:|.:.:|
Human  1012 VNRQSARLWETSI 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	36/173 (21%)
		Reprolysin_2	450..659	CDD:290307	32/150 (21%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
ADAM22	XP_006716091.1	Pep_M12B_propep	127..239	CDD:279848
		Reprolysin	291..490	CDD:279729	35/165 (21%)
		ZnMc_adamalysin_II_like	291..488	CDD:239797	35/163 (21%)
		Disintegrin	505..579	CDD:278623	31/96 (32%)
		ACR	582..723	CDD:214743	26/142 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920