DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Adam8

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_006230561.1	Gene:	Adam8 / 499285	RGDID:	1566394	Length:	868	Species:	Rattus norvegicus

Alignment Length:	873	Identity:	180/873 - (20%)
Similarity:	279/873 - (31%)	Gaps:	297/873 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 PEPMSKDYQKLHRKQL----HKKSAPQQQQQPHPPKKYISGDEDFKYP-HQKYTKE---ANFAEG 356
            |.|..|.|:.:..::|    .::|.|.|.........|..|..:..:. |.:..::   :::.|
  Rat    20 PLPHVKQYEVVWPRRLAASRSRRSLPSQWGLYPESLSYALGTSEQVFTLHLRKNRDLLGSSYTE- 83

  Fly   357 AFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGR---------------- 405
             .|..:.|..:....:..| |.|....|.....:.|.....:|.||..|
  Rat    84 -TYSAANGSEVKEQLHEQD-HCLYQGHVEGYEGSAASISTCAGLSGFFRVGSTVHLIEPLDADEE 146

  Fly   406 -----------EDNKNTCSL--------------YIQTDPLIWRHIRE-------GIADHDRGRK 438
                       |....||.:              ..:..|..|...||       .:||....:|
  Rat   147 GQHAVYQAKHLEQKAGTCGVSETSLDKLGPRTLEIYRAQPGNWLKPREIRYVELYVVADSQEFQK 211

  Fly   439 YEVDEKTREEITSLIAHHVTAVNYIYRNTKFD----GRTEHRNIRFEVQRIKIDDDSACRNSYNG 499
            ....|..|:.:..::.|    |:.:||...|.    |.......:|.:.|
  Rat   212 LGTREAVRQRVLEVVNH----VDKLYRELSFRVVLVGLEIWNKDKFYISR--------------- 257

  Fly   500 PHNAFCNEHMDVSNFL-----NLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICE 559
                :.|  :.:.|||     ||.....|.:   ..:.|..||.|.|:|||.|::       :|.
  Rat   258 ----YAN--VTLENFLSWREQNLLGRHPHDN---VQLITGVDFIGTTVGLAKVSA-------LCS 306

  Fly   560 KYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHD--------- 615
            ::.      |...|...||. .|:.:               |:|||:|||.|..||
  Rat   307 RHS------GAVNQDHTRSA-IGVAS---------------TMAHELGHNLGMNHDENIPGCYCP 349

  Fly   616 YPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNV-LDVLVGNTKRDCF-------KA 672
            .|:|      .|..||..|.       .||| |.:....|.| |:..|.|.:..|.       :.
  Rat   350 IPRE------GGGCIMTESI-------GSKF-PKTFSRCSQVDLESFVTNHQTGCLTNVPDVNRF 400

  Fly   673 SEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPC 737
            ..|..|||..||.||:|||| ..::|::.||              :|..|......:|  :.|.|
  Rat   401 VGGPVCGNLFVERGEQCDCG-TPQDCQNPCC--------------NATTCQLAKGAEC--AHGAC 448

  Fly   738 CLSNSCTFVPTSYHQKCKE-ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSP 801
            |  :.|...|..  :.|:. :.:|.....|:|....|||...:.:.|.|..|  .|..|.|   |
  Rat   449 C--HECKVKPAG--ELCRPMKDKCDLEEFCDGQKPTCPEDAFQQNGTPCPGG--YCFDGSC---P 504

  Fly   802 CL------LWN------MTKCFLTSTTLP-------HVSKRKLCD-LACQDGN---DTSTCR--- 840
            .|      ||.      ...||..|  :|       :.|:...|. |.|:.|.   :.|:|.
  Rat   505 TLAQQCQALWGPGARAASDSCFAFS--IPQGCYGSMYPSRINRCGVLFCEGGQKPLERSSCTFSS 567

  Fly   841 --------STSEFADKYNIQKGGISLQPGSPC-------------------DNFQGYCDVFLKCR 878
                    .|....:.|.....|...:.|..|                   .|..|.|:...:|.
  Rat   568 HHGLCQALQTDSNTNTYEFVLQGTKCEEGKVCMDGNCQDLRVYRSENCSAKCNNHGVCNHKRECH 632

  Fly   879 A-----------VDADGPL-------------------------LRLKNLLLNRKTLQTVAEWIV 907
            .           :.||.|:                         |.|.....:...|::...|..
  Rat   633 CHAGWAPPYCAQLLADVPVVTESAAVHSTTASGNWRGLNSGTVGLGLATTTSSNPLLESQKSWSS 697

  Fly   908 DNW---YLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRR--ARRISETLRAPM-----NTLRRM 962
            ::.   .:|||:.:...||:|:.|   .::..:....:||  |.:.:..|..|:     ::|...
  Rat   698 ESLPVSVVVVLVILVAAVVIGAGI---VIYRKAPKQIQRRSVAPKPTSGLSNPLFYTGDSSLPAK 759

  Fly   963 QRHPN-----QRGAGPRSI-----PPPA 980
            .|.|:     .....||.|     ||||
  Rat   760 SRPPDPPEMVSTNQPPRPIVKPKRPPPA 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	68/313 (22%)
		Reprolysin_2	450..659	CDD:290307	52/227 (23%)
		Disintegrin	684..776	CDD:278623	24/92 (26%)
Adam8	XP_006230561.1	Pep_M12B_propep	51..149	CDD:279848	15/100 (15%)
		Reprolysin	196..395	CDD:279729	61/269 (23%)
		ZnMc_adamalysin_II_like	196..393	CDD:239797	61/267 (23%)
		DISIN	412..486	CDD:214490	25/94 (27%)
		ACR	488..607	CDD:214743	26/125 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920