DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Adam5

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_006253383.1	Gene:	Adam5 / 498654	RGDID:	621471	Length:	773	Species:	Rattus norvegicus

Alignment Length:	170	Identity:	47/170 - (27%)
Similarity:	68/170 - (40%)	Gaps:	34/170 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 FSPCSI--------RNISNVLDVLVGNTKRDCFKASE-GAFCGNKIVESGEECDCGFNEEECKDK 701
            ||.||:        :::..:.|:.:...|:   |.|. ...|||.|:|..|:||||..:.....|
  Rat   355 FSTCSLDDFKYLSTQDLECLQDLPMERQKK---KPSRPRRICGNGILEMNEQCDCGTLKNCTHKK 416

  Fly   702 CCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKC-KEETECSWSST 765
            ||.|              ..|..::|..|  ..|.|| ...|...|.:.  .| |.:.||.:...
  Rat   417 CCDP--------------MSCRLKSKAVC--GSGECC-GQDCKVKPVNV--LCRKSKNECDFEEY 462

  Fly   766 CNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPCL 803
            |||..|.|.......:...|::|.|.|..|.|  |.:.|:
  Rat   463 CNGNDAYCVPDTFARNGQYCDSGQAFCYSGLCMTSNNQCM 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	8/39 (21%)
		Reprolysin_2	450..659	CDD:290307	4/20 (20%)
		Disintegrin	684..776	CDD:278623	27/92 (29%)
Adam5	XP_006253383.1	Pep_M12B_propep	35..141	CDD:279848
		Reprolysin	185..378	CDD:279729	5/22 (23%)
		ZnMc_adamalysin_II_like	185..376	CDD:239797	4/20 (20%)
		Disintegrin	399..474	CDD:278623	27/93 (29%)
		ACR	477..620	CDD:214743	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940