DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Tace

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_733334.1	Gene:	Tace / 43558	FlyBaseID:	FBgn0039734	Length:	732	Species:	Drosophila melanogaster

Alignment Length:	1030	Identity:	229/1030 - (22%)
Similarity:	344/1030 - (33%)	Gaps:	367/1030 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSKC--AFNIVFVSIIF--IIIVNGYAKDISGVKRGHERLNEYISHYETLNYD---HEHIR--A 56
            |.:||  ...:..:|:.|  :.:.|..|            |.:.:.|||..:.|   |..::  |
  Fly     1 MFTKCISCCGLAIISVFFACLFVENCAA------------LQKTLRHYEIFHKDDVVHRVVKRGA 53

  Fly    57 SHNRARRSVTKDQYVHLKFASHGRDFHLRLKRDLNTFSNKLDFY--DSKG---PIDVSTDHIYEG 116
            .|:....:..|:    ::|.:.|::|.|.|....:...:|...|  |:.|   .:.:..|..|.|
  Fly    54 KHSTNPFNTIKE----VEFTTLGKNFRLILHPHRDVLHSKFRAYAVDADGNETVVHMDHDSFYSG 114

  Fly   117 EVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKST 181
            .|.|:..|.|...|.:|.....|....:.|::|.:..:.|..:..|            ..|.|::
  Fly   115 RVFGELESSVRAHIEDGTMTMSIHLPEETYHIEPSWRHLPEAKKDT------------MVAYKAS 167

  Fly   182 QPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERN 246
            .     .|.:.:......||..:||:..|.                             ::||..
  Fly   168 D-----VKVHKNEAGATPKTCGYIKEGLEL-----------------------------EDKEHG 198

  Fly   247 AEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLH 311
              |.||
  Fly   199 --DTLD----------------------------------------------------------- 202

  Fly   312 RKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADW 376
             .:||.:...|..|..:.|
  Fly   203 -NELHTREKRQSDQYEYTP---------------------------------------------- 220

  Fly   377 HQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEV 441
                                           .|..|.|.:..|...::.:..|
  Fly   221 -------------------------------TKTRCPLLLVADYRFFQEMGGG------------ 242

  Fly   442 DEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIR---FEVQRIKIDDDSACRNSYNGPHNA 503
              .|:..|..||: .:..|:.||.:|.:..|::....:   |.:::|.:..:.. |......|..
  Fly   243 --NTKTTINYLIS-LIDRVHKIYNDTVWQDRSDQEGFKGMGFVIKKIVVHSEPT-RLRGGEAHYN 303

  Fly   504 FCNEHMDVSNFLNLHSLE-DHSDFCLAYVFTYRDFTGGTLGLAWVASASGAS-GGIC--EKYKT- 563
            ...|..||.|.|.:.|.| .|.|||||::||...|.||.||||:|.|....| ||||  |.:|.
  Fly   304 MIREKWDVRNLLEVFSREYSHKDFCLAHLFTDLKFEGGILGLAYVGSPRRNSVGGICTPEYFKNG 368

  Fly   564 YTETVGGQYQSTKRSLNTGIITFVN-YNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ--ECRP-GG 624
            ||           ..||:|:.:..| |..||..:.:.|..|||.|||:||.|| |.  ||.| ..
  Fly   369 YT-----------LYLNSGLSSSRNHYGQRVITREADLVTAHEFGHNWGSEHD-PDIPECSPSAS 421

  Fly   625 LNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEEC 689
            ..|:::|:..:.||...||.||||||:|:|..||....|.    ||...|.:||||..||..|:|
  Fly   422 QGGSFLMYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGR----CFSEPEESFCGNLRVEGDEQC 482

  Fly   690 DCGFNEEECKDKCCYPRLISEYDQSLNSSAKGC--TRRAKTQCSPSQGPCCLSNSCTFVPTSYHQ 752
            |.|....|..|.||               .|.|  .|.....||....|||  .:|.|:.:.  .
  Fly   483 DAGLLGTEDNDSCC---------------DKNCKLRRNQGAMCSDKNSPCC--QNCQFMASG--M 528

  Fly   753 KCKEE--TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLW----NMTKCF 811
            ||:|.  ..|...:.|.|..||||:.....|.|.|..      ||:|....|:.:    .:..|
  Fly   529 KCREAQYATCEQEARCTGAHAECPKSPAMADGTTCQE------RGQCRNGKCVPYCETQGLQSC- 586

  Fly   812 LTSTTLPHVSKRKLCDL---ACQDGNDTSTCR-STSEFADKYNIQKGGISLQPGSPCDNFQGYCD 872
                         :||:   ||:     ..|| |.:|..  :.::...: |..|:||  ..|:|
  Fly   587 -------------MCDIIADACK-----RCCRMSINETC--FPVEPPDV-LPDGTPC--ITGFC- 627

  Fly   873 VFLKCRAVDADGPLLRLKNLLLNRKTLQTVAE--W--------------IVDNWYLVVLMGVAFI 921
                              |..:..||:|.|.|  |              :.||    ::|.|..:
  Fly   628 ------------------NKGVCEKTIQDVVERFWDIIEEINVAKTLRFLKDN----IVMAVVLV 670

  Fly   922 VVMGSFIKCCAVHTPSSNPKKRRARRISE-----TLRAPMNTLRRM--QRHPNQR 969
            ..: .:|....|.:.....|.|...::.|     .|..|.:..||:  .|.|.|:
  Fly   671 TAV-FWIPISCVISYFDRKKLRHEMKLIEWSQKLDLIHPSDERRRVIHIRVPRQK 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	92/278 (33%)
		Reprolysin_2	450..659	CDD:290307	81/220 (37%)
		Disintegrin	684..776	CDD:278623	29/95 (31%)
Tace	NP_733334.1	Pep_M12B_propep	50..162	CDD:279848	26/127 (20%)
		ZnMc_TACE_like	223..470	CDD:239798	92/278 (33%)
		Reprolysin_2	244..456	CDD:290307	83/225 (37%)
		Disintegrin	477..552	CDD:278623	27/93 (29%)
		ADAM17_MPD	576..633	CDD:271205	16/99 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950