DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and Kul

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001287589.1	Gene:	Kul / 43501	FlyBaseID:	FBgn0039688	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	1485	Identity:	409/1485 - (27%)
Similarity:	607/1485 - (40%)	Gaps:	407/1485 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RLNEYISHYETLNYDHE--------HIRASHNRARRSVTKD-----QYVHLKFASHGRDFHLRLK 87
            ||..||.|:|..|:|.:        |:..:..|.:|.||..     ..:.|.|::|.|||.|.|:
  Fly    39 RLTPYIKHWEAANFDRQVLQAAQVRHLEQARFRQKREVTPSASGLAHTIRLNFSAHDRDFRLVLR 103

  Fly    88 RDLNT-FSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSI-HNGVFEGKIITERDAYYVEH 150
            :..:: |::.::..::.||||.....||.|.:..|..::|...: .:.:.:|.|.|:.:.||:|.
  Fly   104 QQPHSVFAHDVEIENTLGPIDYDVSRIYTGSLEDDEAAHVQAILTSDNLLDGTIETQAEHYYIEP 168

  Fly   151 AKHY-------------------------FPTNRTATTTP----------------PSTSTTSSA 174
            |..|                         |......:.||                |.....|.|
  Fly   169 AHRYSQQLAESGVHSIVYKLSDVNMQKQQFTGGGLNSATPAKTHCASEKLRKKRWLPEELAMSDA 233

  Fly   175 TTATKSTQPTRPL---AKSNTSTTAVNS---KTENFIKKIAESTTTSQQLPEYTESSSSSTTTFP 233
            ...|.:..|..||   ...|.....:.|   |:|...:|. .:|:|::.....|||..::.|  .
  Fly   234 PAPTYNRNPPLPLDLEVPYNDDFRVLASEEDKSEESPRKY-PTTSTTRSTVRSTESFLATLT--K 295

  Fly   234 PTTEYFEDEKERNAEDELDFHSII---YKESHVEDAYENVREG-HVAGCGITDEVSQWMENIQNS 294
            ||:       .||         |:   |..|::.:...:...| :.|.....:..|....|..||
  Fly   296 PTS-------NRN---------ILVNNYNPSNLGEGSRSYSSGNNNANSNSNNNNSNNNNNNNNS 344

  Fly   295 AVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKE--ANFAEGA 357
                     :.:.:||:.|  ||........:|..|:    ....::.|:...|:|  :||
  Fly   345 ---------NNNVRKLYTK--HKNIIVSTYNRPIEPE----FGTPYEEPNNNGTRELPSNF---- 390

  Fly   358 FYDPSTGRRLGSSANVADWHQLVHE-RVRRATDNGAGDRG------------------------- 396
            |....|...||::.|..|  :..|: .|...|.|||..:.
  Fly   391 FNANWTTLFLGNNNNGND--RPSHKTHVEIITKNGATKKPNIIVNNYNPEIIFAPNPHNPSFNSM 453

  Fly   397 --SSGGSGRGRE----------DNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEI 449
              ::..||||.|          |.|.||.||:|             |||...:|...||.:.|.|
  Fly   454 MMTNLLSGRGGEDIHSSPRLLYDRKTTCMLYLQ-------------ADHTFFQKMGSDEASIEAI 505

  Fly   450 TSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRN-SYNGPHNAFCNEHMDVSN 513
            |    .||...|.|||||.|:...:..||.|.::|||:.:.:|.:: ||..|.|      ..|..
  Fly   506 T----RHVQRANTIYRNTDFNNDGKPDNITFMIKRIKVHNMNAMKDPSYRFPGN------YGVEK 560

  Fly   514 FLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS 578
            ||.|.|.||:..|||||:||||||..|||||||......| ||:|||        .|.|:.:.:|
  Fly   561 FLELFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNA-GGVCEK--------NGHYRGSLKS 616

  Fly   579 LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNN 643
            |||||:|.:||...|||.||.:||||||||||||||| |::|.|||.:||:||||.|||||:.||
  Fly   617 LNTGIVTLLNYGKHVPPAVSHVTLAHEIGHNFGSPHD-PEQCTPGGEDGNFIMFARATSGDKKNN 680

  Fly   644 SKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCY---- 704
            :|||.||:::|..||:....:.| .||...:.:.|||.:||.||:||||: ||:|||.||:
  Fly   681 NKFSTCSLKSIEPVLNAKARSMK-GCFTEPQSSICGNGVVEPGEQCDCGW-EEDCKDSCCFPMSR 743

  Fly   705 -PRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNG 768
             |||    |::      .||.....:||||||||| :..|..   .:..||:::..|...|.|:|
  Fly   744 QPRL----DET------PCTLTPHARCSPSQGPCC-TTDCKL---KFGDKCRDDNGCRDPSFCDG 794

  Fly   769 TTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDG 833
            ...:||...::.:||:||. ..:|..|:|:||.||.:.:..|  .....|...:.|.|:|.|:..
  Fly   795 RVPQCPPSVNKPNKTICNK-EFVCYMGDCTGSICLAYGLESC--QCIPGPQDDRIKSCELCCKLP 856

  Fly   834 NDTSTCRSTSEF-------ADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKN 891
            .:.|.|||:.|:       .|.|:        :||:||:::.||||||.|||.||..|||..|:.
  Fly   857 GEDSPCRSSFEWNEAPFDVPDMYS--------KPGTPCNDYNGYCDVFQKCREVDPSGPLATLRK 913

  Fly   892 LLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRI----SETL 952
            |||:.:::.:..:|:..|||.|.|..|..|:::....|..|   ..||.|.:....|    :||:
  Fly   914 LLLSEESIASFKKWMQHNWYTVALAAVGVILLLALSTKLLA---KRSNLKLKSVTIIHSATTETV 975

  Fly   953 RAPMN-------TLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRGGG---GGGGGRHGGSR 1007
            |.|.|       |..|.:....::..|.|:..|             |.|.|   ....|....::
  Fly   976 RLPENNNGVIVHTAVRTKVPFKKKVRGERTKKP-------------GTGAGVTAAAAVGTRNAAK 1027

  Fly  1008 SHHQQHPHDWDRHQ-------------------GGH--SIVPLPTGGSHSSRNSAANQARRSDGR 1051
            |.....|....|.|                   |.|  .|:      .:|:||:..:.|......
  Fly  1028 SSANPEPKKTTRSQAMAKKKSFEEEPKKSSKKVGKHMKEII------DYSNRNNNGDDASNLSTT 1086

  Fly  1052 GPRSTSSGRPQ-------AIASGSGAASGAARSHGGYGAEQAIP--------------GS----- 1090
            ...:.:.|:.|       .:|........::|........|:.|              |:
  Fly  1087 NNHTNTFGKVQKWLLESPIVAQPLSHIEHSSRVRKVMSKSQSTPERLVQKTPQKTKSMGNLSNEK 1151

  Fly  1091 ---------------------------IGGGVQAAIS------SGG------VVARAQ------- 1109
                                       :|.||:...|      :||      |..||:
  Fly  1152 VKLQVVYKPPFKFSLRLSKKPKVKTHVVGAGVRPKRSQKTSNRTGGQSSSKEVSTRAKRSALLLC 1216

  Fly  1110 -------------------LPLPLPPPNGQ---QQMQQQQQLQLQQPA----ISPQQQPQQAF-Y 1147
                               |..|.||.:.:   :.:..|.:....:|:    ::|..|.:.:. .
  Fly  1217 NEAEDDNQILTLNEPNYETLKPPTPPRSMEHCYENVDMQAEASSSKPSSSSKVAPSSQNRASLEV 1281

  Fly  1148 TPKELPPRNKSRSSRTNNTSNTTTTTNSSTAAAGSGSVS-------------------------- 1186
            ||.....||..|.|.:.:|.|........:::..||||:
  Fly  1282 TPPVTAQRNSYRRSNSLSTHNPFAAAPRRSSSKASGSVNLTRNFGSTQNLINLSQNLSKNKKRSS 1346

  Fly  1187 ----GPGSGAGSSSKS--KSGKSAKAKDSKSQKSQQANNSRSSSKEKGVKPVRRN 1235
                ..||||..|.|.  ..|.::..:.|.|..:.:.::|.||||...|.|.|.:
  Fly  1347 LNLKASGSGATRSGKDPPTMGVASPQRRSSSNANLRRDSSVSSSKAVPVPPTRNS 1401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	125/267 (47%)
		Reprolysin_2	450..659	CDD:290307	108/209 (52%)
		Disintegrin	684..776	CDD:278623	38/96 (40%)
Kul	NP_001287589.1	Pep_M12B_propep	72..174	CDD:279848	29/101 (29%)
		ZnMc_TACE_like	479..713	CDD:239798	125/267 (47%)
		Reprolysin_2	502..696	CDD:290307	110/213 (52%)
		Disintegrin	720..803	CDD:278623	38/97 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4570
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14962at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3482
	5	4.970