DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and ADAM11

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_005257430.1	Gene:	ADAM11 / 4185	HGNCID:	189	Length:	774	Species:	Homo sapiens

Alignment Length:	471	Identity:	108/471 - (22%)
Similarity:	161/471 - (34%)	Gaps:	169/471 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 RHIREG---------------IADHDRGRKYEVDEKTREEI--TSLIAHH-VTAVNYIYR---NT 467
            |.:|.|               |.||      ::.|:.|:.:  ||..|.. |...:.||:   ||
Human   225 RQVRRGHPTVHSETKYVELIVINDH------QLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNT 283

  Fly   468 KF---------DGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDH 523
            :.         ||           .:|::.||..              |.:..........|.:.
Human   284 RIVLVAMETWADG-----------DKIQVQDDLL--------------ETLARLMVYRREGLPEP 323

  Fly   524 SDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVN 588
            ||  ..::|:.|.|...:.|.|:|       ||||      :.:.||           |:..:.|
Human   324 SD--ATHLFSGRTFQSTSSGAAYV-------GGIC------SLSHGG-----------GVNEYGN 362

  Fly   589 YNSRVPPKVSQLTLAHEIGHNFG---SPH-DYPQECRPGGL--------NGNYIMFASATSGDRP 641
            ..:..      :|||..:|.|.|   :.| ....:|:...:        .|.|:          |
Human   363 MGAMA------VTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYL----------P 411

  Fly   642 NNSKFSPCSIRNISNVLDVLVGNTKRDC-----FKASEGAFCGNKIVESGEECDCGFNEEECK-- 699
            .  |||.|||...:..|....|:    |     .|..:...|||..||:||||||| :.:||.
Human   412 R--KFSRCSIDEYNQFLQEGGGS----CLFNKPLKLLDPPECGNGFVEAGEECDCG-SVQECSRA 469

  Fly   700 -DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSW 762
             ..||                |.||......|  |.|.||  ..|.:.|...  .|:|. .||..
Human   470 GGNCC----------------KKCTLTHDAMC--SDGLCC--RRCKYEPRGV--SCREAVNECDI 512

  Fly   763 SSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWNMTKCFLTSTTLPHVSKRK 824
            :.||.|.:::||...|:.|...|::....|..|.|.  ...| :||.            |.:..:
Human   513 AETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWG------------HAAADR 565

  Fly   825 LC-DLACQDGNDTSTC 839
            .| :....:|.:..:|
Human   566 FCYEKLNVEGTERGSC 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/299 (20%)
		Reprolysin_2	450..659	CDD:290307	48/233 (21%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
ADAM11	XP_005257430.1	Pep_M12B_propep	76..188	CDD:279848
		Reprolysin	239..438	CDD:279729	56/277 (20%)
		ZnMc_adamalysin_II_like	239..436	CDD:239797	56/275 (20%)
		Disintegrin	453..527	CDD:278623	31/96 (32%)
		ACR	530..668	CDD:214743	12/64 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920