Protein Alignment kuz and adam10b

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_956714.1
• Gene: adam10b / 393392
• ZFINID: ZDB-GENE-071115-1
• Length: 780
• Species: Danio rerio
• Alignment Length: 1039
• Identity: 353/1039 - (33%)
• Similarity: 494/1039 - (47%)
• Gaps: 299/1039 - (28%)

  Fly    28 SGVKRGH--ERLNEYISHYETLNYDHEHIRASHNRARRSVT-KDQYVHLKFASHGRDFHLRLKRD 89
            ||..||:  ..||:||.|||.|:||.|.:.:.|.||:|:.| .::.:.|:|.:|||.|:||::||
Zfish    22 SGPARGYYGNPLNKYIRHYEGLSYDTEMLHSDHQRAKRAATHTERTLQLEFHAHGRHFNLRMRRD 86

  Fly    90 LNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHY 154
            ...|::......|...:|..|.|||.||:.|::.:...||:.:|.|||.|:|.|..:|||
Zfish    87 TGLFADDFKLEVSGQEMDYDTSHIYSGEIYGEQGTLTHGSVQDGRFEGFILTHRGTFYVE----- 146

  Fly   155 FPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLP 219
                                                                             
Zfish   147 ----------------------------------------------------------------- 146

  Fly   220 EYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEV 284
                          |...|.:|:       .:.|||:||.|..::..:   :.|...||.
Zfish   147 --------------PVERYLQDK-------NVPFHSVIYHEDDIDYPH---KYGPAGGCA----- 182

  Fly   285 SQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTK 349
                    :::|          :||:.|.|    |...|:....||.:    |||
Zfish   183 --------DASV----------FQKMKRYQ----STAHQEPTDSPPAQ----DED---------- 211

  Fly   350 EANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSL 414
                                          |..|.:|.|                 :..||||.|
Zfish   212 ------------------------------VLLRKKRMT-----------------QVEKNTCQL 229

  Fly   415 YIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIR 479
            :||||.|.:::.                 ||||.:.:.|:.||.|::.||:.|.|.|   .|||.
Zfish   230 FIQTDHLFYKYY-----------------KTREAVIAQISSHVKAIDAIYQGTDFMG---IRNIS 274

  Fly   480 FEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGL 544
            |.|:||:|:..|..|:.    .|.|...::.|..||.|:|.::|.|:|||||||.|||..|.|||
Zfish   275 FMVKRIRINTTSDERDR----SNPFRFANIGVEKFLELNSEQNHDDYCLAYVFTDRDFDDGVLGL 335

  Fly   545 AWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHN 609
            |||.:.:|:|||||||.|.|::       ..|:||||||||..||.|.||||||.:|.|||:|||
Zfish   336 AWVGAPAGSSGGICEKNKLYSD-------GKKKSLNTGIITVQNYASHVPPKVSHITFAHEVGHN 393

  Fly   610 FGSPHDYPQECRPGGL-------NGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKR 667
            ||||||...||.||..       .|||||:|.|||||:.||:|||.|||:|||.||:...|:
Zfish   394 FGSPHDSGSECTPGESKSPDKKERGNYIMYARATSGDKLNNNKFSVCSIKNISQVLEKKRGS--- 455

  Fly   668 DCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSP 732
             ||..|....|||.:||.||:||||:: ::|||.|||     :.:|..|   |.|..:....|||
Zfish   456 -CFVESGQPICGNGLVEPGEQCDCGYS-DQCKDDCCY-----DANQPDN---KKCKLKPGKVCSP 510

  Fly   733 SQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC 797
            |||||| :..|::  ..:::||:||:||:....|:|::|:||....:.:.|.|:..|.:|:.|.|
Zfish   511 SQGPCC-TFECSY--KGHNEKCREESECAHQGLCSGSSAQCPTSEPKANFTACHGNTQVCLNGGC 572

  Fly   798 SGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRST-SEFADKYNIQKGGISLQPG 861
            |||.|..:.:..|  |..::....:.:||.:.|.:..:.|||.|| ||...:: ..|..|:||.|
Zfish   573 SGSICEKYGLEVC--TCASVEGKDETELCHVCCMEKMNPSTCSSTGSERLSRF-FGKRVITLQAG 634

  Fly   862 SPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGS 926
            |||::|:||||||:|||.|||||||.|||..:.|.:..:.:|||::.:|:.|:|||:|.|::|..
Zfish   635 SPCNDFKGYCDVFMKCRLVDADGPLARLKKAIFNPELYENIAEWMMAHWWAVLLMGIALIMLMAG 699

  Fly   927 FIKCCAVHTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGD 991
            |||.|:|||||||||....:.:..||:      ||..:|.:|.       |||
Zfish   700 FIKICSVHTPSSNPKLPPPKPLPGTLK------RRRAQHSSQH-------PPP------------ 739

  Fly   992 GRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSI-----VPLPTGGSH--SSR-NSAANQARR 1047
                            ||.|..||       .|::     .|.|....|  |:| |....|.||
Zfish   740 ----------------SHQQAVPH-------AHALPNPRPAPRPQPARHHRSARENYQMGQMRR 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	131/273 (48%)
		Reprolysin_2	450..659	CDD:290307	113/215 (53%)
		Disintegrin	684..776	CDD:278623	38/91 (42%)
adam10b	NP_956714.1	Pep_M12B_propep	54..154	CDD:279848	39/183 (21%)
		ZnMc_TACE_like	225..464	CDD:239798	131/273 (48%)
		Reprolysin_2	245..449	CDD:290307	113/217 (52%)
		Disintegrin	471..551	CDD:278623	38/91 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H113979
Inparanoid	1	1.050	583	1.000	Inparanoid score	I975
OMA	1	1.010	-	-		QHG48710
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0006327
OrthoInspector	1	1.000	-	-		otm26226
orthoMCL	1	0.900	-	-		OOG6_104685
Panther	1	1.100	-	-	LDO	PTHR45702
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3482
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980