DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and Gm5347

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001073400.1	Gene:	Gm5347 / 384814	MGIID:	3647274	Length:	713	Species:	Mus musculus

Alignment Length:	697	Identity:	143/697 - (20%)
Similarity:	228/697 - (32%)	Gaps:	280/697 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 GSGRGR-EDNKNTCSLYIQTDPLIWRHI--------------REGIADHDRGRKYEVDEKTREEI 449
            ||.:|. |.|..|..:..::....:.|:              |.|:::.:..|:.::.|.....:
Mouse   129 GSLQGTLEINGTTYEIMPKSSTSTFEHLAYKMESGESEPSPMRCGLSEEEIARQMKLQESNASTL 193

  Fly   450 TSL-----IAHH--------VTAVNYIYRN------------------------------TKFDG 471
            ..:     ..||        :....|::||                              ||.:.
Mouse   194 LQIPYENWWTHHRFIDYFVVIDHKRYVHRNNNTTTCIQDMLQVVNGINGYYLQIQTDVVLTKLEV 258

  Fly   472 RTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDFCLAYVFTYRD 536
            .:::..|..|.:..|:             ..||||..:........|.        :.::|..|.
Mouse   259 WSQNNLINVEQEMSKV-------------LGAFCNWKIKTIGKRVRHD--------IIHLFVRRS 302

  Fly   537 FTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLT 601
            : |..||||:|       |.:|                  .:||..:      ||.:...:|.:.
Mouse   303 Y-GIYLGLAYV-------GTVC------------------LTLNCAV------NSFLSDSLSDMA 335

  Fly   602 --LAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGN 664
              :|||:|||||..|| ...|..|       :.:...:..:.|:.|||.||...:.:|:
Mouse   336 FIIAHEMGHNFGMMHD-GSACTCG-------LHSCIMAPHKSNSPKFSNCSYEEMFSVV------ 386

  Fly   665 TKRDCFKASEGAF---------CGNKIVESGEECDCGFNEEEC-KDKCCYPRLISEYDQSLNSSA 719
            |||.|......|.         |||.:||.||:|||| |.|.| :|.||               :
Mouse   387 TKRSCLYDIPDALKTINLMPTKCGNNLVEEGEQCDCG-NSESCLQDPCC---------------S 435

  Fly   720 KGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKT 783
            ..|..:...:|  :.|.||  .:|.|:...  ..|::| .||.....||||:.|||...::.|..
Mouse   436 SNCVFKPGAKC--AFGRCC--KNCQFLKAG--TVCRQEKNECDLPEWCNGTSGECPGDVYKADGI 494

  Fly   784 MCNNGTALCIRGEC----------------SGSPCLLWNMTK-------CFLTSTTLPHVSKRKL 825
            .|:.| ..|.:.||                |........|.:       |...|      ||.|:
Mouse   495 RCSRG-GYCYKMECQRHNRQCREIFGKRSRSADEICYMEMNRRGDRFGNCGNDS------SKYKI 552

  Fly   826 CDLA--------CQD--------GNDT--------STCRSTSEFADKYNIQKGGISLQPGSPCD- 865
            |:|.        |::        .::|        :|| .|.::.....|...| ::..|:||.
Mouse   553 CELTDVLCGRIQCENVIQLPQRRNHETVHFTHFSNNTC-WTMDYHFGITIDDVG-AVSDGTPCAP 615

  Fly   866 ------------------------NFQGYCDVFLKCR-----------------AVDADGPLLRL 889
                                    :.||.|:....|.                 ::|:..|.:.|
Mouse   616 DHICLDRKCVSKSVLVSNCTPQLCHMQGVCNNKDHCHCNNTWEPPDCQLRGHGGSIDSGPPPVPL 680

  Fly   890 KNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIV--VMGSFIKCCAVH 934
            .                ..||.:..|   |||:  |:| ||....:|
Mouse   681 S----------------PSNWSMYFL---AFIIMYVLG-FIALYGIH 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	59/325 (18%)
		Reprolysin_2	450..659	CDD:290307	49/253 (19%)
		Disintegrin	684..776	CDD:278623	31/93 (33%)
Gm5347	NP_001073400.1	Pep_M12B_propep	40..158	CDD:366707	7/28 (25%)
		ZnMc_adamalysin_II_like	206..394	CDD:239797	51/254 (20%)
		Disintegrin	415..487	CDD:365943	31/93 (33%)
		ACR	491..627	CDD:214743	25/144 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010